课题组长
姓名：
徐华强中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
课题组简介
研究内容：
针对三大家族蛋白受体：核激素受体、肝脏生长因子(HGF)受体以及GPCR，研究激素通路的蛋白质复合体的结构与功能，开展基于晶体结构的肿瘤与糖尿病的药物研发。
代表性论文（*第一作者，#通讯作者）
- 1. Soon, Fen-Fen*; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M. H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten#; Xu, H. Eric#.Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases.SCIENCE. 2012. 335(6064):85-88.
- 2. Ke, Jiyuan#*; Zhang, Chenghai; Harikumar, Kaleeckal G.; Zylstra-Diegel, Cassandra R.; Wang, Liren; Mowry, Laura E.; Miller, Laurence J.; Williams, Bart O.; Xu, H. Eric#.Modulation of beta-Catenin Signaling by Glucagon Receptor Activation.PLOS ONE. 2012. 7(3).
- 3. Yu, Shanghai*; Xu, H. Eric#.Couple Dynamics: PPAR gamma and Its Ligand Partners.STRUCTURE. 2012. 20(1):2-4.
- 4. Melcher, Karsten#*; Xu, Yong; Ng, Ley-Moy; Zhou, X. Edward; Soon, Fen-Fen; Chinnusamy, Viswanathan; Suino-Powell, Kelly M.; Kovach, Amanda; Tham, Fook S.; Cutler, Sean R.; Li, Jun; Yong, Eu-Leong; Zhu, Jian-Kang; Xu, H. Eric#.Identification and mechanism of ABA receptor antagonism.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2010. 17(9):1102.
- 5. Melcher, Karsten*; Ng, Ley-Moy; Zhou, X. Edward; Soon, Fen-Fen; Xu, Yong; Suino-Powell, Kelly M.; Park, Sang-Youl; Weiner, Joshua J.; Fujii, Hiroaki; Chinnusamy, Viswanathan; Kovach, Amanda; Li, Jun; Wang, Yonghong; Li, Jiayang; Peterson, Francis C.; Jensen, Davin R.; Yong, Eu-Leong; Volkman, Brian F.; Cutler, Sean R.; Zhu, Jian-Kang; Xu, H. Eric#.A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.NATURE. 2009. 462(7273):606.
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