课题组长
姓名：
许红涛助理教授 研究员 博士生导师, PhD, 助理教授
职务：
所在院所：
生命科学与技术学院、免疫化学研究所
荣誉称号：
教育经历：
-
2002/09—2006/07，郑州大学，学士
-
2009/09—2014/07，中国科学院上海药物研究所，博士
博士后及工作经历：
- 2014/08—2017/09，上海科技大学免疫化学研究所，抗体化学实验室，博士后
- 2017/10—2020/07，上海科技大学免疫化学研究所，抗体设计学实验室，助理研究员
- 2020/08—2026/07，上海科技大学免疫化学研究所，抗体设计学实验室，副研究员
- 2026/08—至今，上海科技大学生命科学与技术学院/免疫化学研究所，助理教授（TENURE-TRACK）
课题组简介
研究方向：
核酸编码组合库技术、活细胞原位筛选技术、硒药物化学生物学
研究内容：
以核酸编码组合库技术(Phage display, mRNA display, DEL)为基础，深度融合合成化学与前沿生命科学方法，系统开展面向重大疾病相关靶标的治疗性生物大分子、环肽及小分子的高效筛选、靶标功能验证与候选药物开发。具体内容包括： 1. 组合库技术(Phage display, mRNA display, DEL)开发 2. 活细胞原位组合库筛选技术开发 3. 硒药物化学生物学
研究成果展示
聚焦核酸编码组合库技术，系统开展重大疾病相关靶标的治疗性生物大分子、环肽及小分子的高效筛选、靶标功能验证与候选药物开发；建成覆盖“建库—筛选—验证”全链条研究的nDEL系统；自主研发单链DEL编码系统与活细胞原位DEL筛选技术；首次提出并系统发展“硒–氮交换（SeNEx）”点击化学，拓展硒元素在化学生物学与药物发现中的应用新范式；以第一作者或通讯作者在Chem、Angew. Chem.、J. Am. Chem. Soc.、Nat. Commun.等期刊发表多篇论文，总被引3000余次，H-index=35；参编4个英文专著章节；入选斯坦福大学与Elsevier联合发布的“全球前2%顶尖科学家”年度榜单。
代表性论文（*第一作者，#通讯作者）
- 1. Li, Jie*; Yao, Ying*; Zhang, Shuning*; Wang, Wei; Bi, Wanting; Lv, Jian; Hou, Wei#; Ma, Peixiang#; Xu, Hongtao#.Splint RNA-mediated single-stranded DNA-encoded library construction and label-free live-cell selection.Chem. 10 Mar 2026. 12(7):102945.
- 2. Zhou, Wei*; Wang, Yan*; Zhang, Shuning*; Zhang, Chengwei*; Pang, Jiacheng; Hou, Shaoneng; Li, Jie; Yao, Ying; Su, An#; Ma, Peixiang#; Xu, Hongtao#; Hou, Wei#.Highly selective and AI-predictable Se-N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis.CHEMICAL SCIENCE. 07 Jan 2026. 17(1):225-239.
- 3. Hou, Wei*#; Zhou, Xiaohui*; Yang, Zhikun*; Xia, Huhui*; Wang, Yan; Xu, Keren; Hou, Shaoneng; Zhang, Shuning; Cui, Dongmei; Ma, Peixiang; Zhou, Wei#; Xu, Hongtao#.Multicomponent Reaction Integrating Selenium(II)-Nitrogen Exchange (SeNEx) Chemistry and Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC).ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 11 Apr 2025. 64(16).
- 4. Hou, Wei*; Zhang, Shuning*; Yi, Wei#; Ma, Peixiang#; Xu, Hongtao#.DNA-compatible chemistry for DNA-encoded libraries and beyond.Trends in Chemistry. 03 Dec 2025. 7(12):771-786.
- 5. Li, Haoran*; Liu, Yuwei*; Zhang, Silin*; Ma, Lei; Zeng, Zhongyi; Zhou, Zhi; Gandon, Vincent; Xu, Hongtao#; Yi, Wei#; Wang, Shengdong#.Access to N -α-deuterated amino acids and DNA conjugates via Ca(II)-HFIP-mediated reductive deutero-amination of α-oxo-carbonyl compounds.NATURE COMMUNICATIONS. 20 Feb 2025. 16(1):1816.
- 6. Hou, Wei*#; Zhang, Yiyuan*; Huang, Fuchao*; Chen, Wanting*; Gu, Yuang; Wang, Yan; Pang, Jiacheng; Dong, Hewei; Pan, Kangyin; Zhang, Shuning; Ma, Peixiang; Xu, Hongtao#.Bioinspired Selenium-Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole-Scale Medicinal Chemistry and Bioconjugation.ANGEWANDTE CHEMIE - INTERNATIONAL EDITION. 08 Apr 2024. 63(15):e202318534.
- 7. Ma, Peixiang*; Zhang, Shuning; Huang, Qianping; Gu, Yuang; Zhou, Zhi; Hou, Wei#; Yi, Wei; Xu, Hongtao.Evolution of chemistry and selection technology for DNA-encoded library.Acta Pharmaceutica Sinica B. Feb 2024. 14(2):492-516.
- 8. Zhang, Silin*; Zhang, Haiman*; Liu, Xiawen*; Qi, Ping; Tan, Tingting; Wang, Shengdong; Gao, Hui; Xu, Hongtao#; Zhou, Zhi#; Yi, Wei#.Mask and Release Strategy-Enabled Diversity-Oriented Synthesis for DNA-Encoded Library.ADVANCED SCIENCE. 09 Feb 2024. 11(6):2307049.
- 9. Zhou, Zhi*; Gu, Yuang*; Wu, Liexin*; Wang, Yan*; Xu, Huiying; Ma, Lei; Zhang, Zhaoyong; Zhao, Jincun; Zhang, Wei; Peng, Wei; Yang, Guang; Yu, Xiyong; Xu, Hongtao#; Yi, Wei#.Organo-Se BTSAs-enabled performance: From racemic and asymmetric synthesis to click chemistry application.CHEM. 09 Nov 2023. 9(11):3335-3346.
- 10. Xu, Hongtao*#; Wang, Yan*; Dong, Hewei; Zhang, Yiyuan; Gu, Yuang; Zhang, Shuning; Meng, Yu; Li, Jie; Shi, Xiao Jie; Ji, Qun; Liu, Lili; Ma, Peixiang; Ma, Fei#; Yang, Guang#; Hou, Wei#.Selenylation Chemistry Suitable for On-Plate Parallel and On-DNA Library Synthesis Enabling High-Throughput Medicinal Chemistry.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 26 Aug 2022. 61(35):e202206516.
- 11. Xu, Hongtao*#; Tan, Tingting*; Zhang, Yiyuan; Wang, Yan; Pan, Kangyin; Yao, Ying; Zhang, Shuning; Gu, Yuang; Chen, Wanting; Li, Jie; Dong, Hewei; Meng, Yu; Ma, Peixiang#; Hou, Wei#; Yang, Guang#.Metal-Free and Open-Air Arylation Reactions of Diaryliodonium Salts for DNA-Encoded Library Synthesis.ADVANCED SCIENCE. 15 Sep 2022. 9(26):2202790.
- 12. Wang, Shuyue*; Shi, Xiaojie*; Li, Jie*; Huang, Qianping; Ji, Qun; Yao, Ying; Wang, Tao; Liu, Lili; Ye, Min; Deng, Yun; Ma, Peixiang#; Xu, Hongtao#; Yang, Guang#.A Small Molecule Selected from a DNA-Encoded Library of Natural Products That Binds to TNF-alpha and Attenuates Inflammation In Vivo.ADVANCED SCIENCE. 25 Jul 2022. 9(21):2201258.
- 13. Ma, Fei*; Li, Jie; Zhang, Shuning; Gu, Yuang; Tan, Tingting; Chen, Wanting; Wang, Shuyue; Xu, Hongtao#; Yang, Guang#; Lerner, Richard A.#.Metal-Catalyzed One-Pot On-DNA Syntheses of Diarylmethane and Thioether Derivatives.ACS CATALYSIS. 04 Feb 2022. 12(3):1639-1649.
- 14. Hou, Wei*#; Xu, Hongtao#.Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities br.JOURNAL OF MEDICINAL CHEMISTRY. 24 Mar 2022. 65(6):4436-4456.
- 15. Hou, Wei*#; Dong, Hewei; Zhang, Xiang#; Wang, Yan; Su, Lin; Xu, Hongtao#.Selenium as an emerging versatile player in heterocycles and natural products modification.DRUG DISCOVERY TODAY. Aug 2022. 27(8):2268-2277.
- 16. Gao, Hui*; Lin, Shuang*; Zhang, Shuning*; Chen, Weijie; Liu, Xiamen; Yang, Guang; Richard A. Lerner; Xu, Hongtao#; Zhou, Zhi#; Yi, Wei#.gem-Difluoromethylene Alkyne-Enabled Diverse C-H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 25 Jan 2021. 60(4):1959-1966.
- 17. Zheng, Qinheng*; Xu, Hongtao*; Wang, Hua; Du, Wen-Ge Han; Wang, Nan; Xiong, Huan; Gu, Yuang; Noodleman, Louis; Sharpless, K. Barry#; Yang, Guang#; Wu, Peng#.Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 17 Mar 2021. 143(10):3753-3763.
- 18. Xu, Hongtao*; Gu, Yuang*; Zhang, Shuning; Xiong, Huan; Ma, Fei; Lu, Fengping; Ji, Qun; Liu, Lili; Ma, Peixiang; Hou, Wei#; Yang, Guang#; Lerner, Richard A.#.A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 03 Aug 2020. 59(32):13273-13280.
- 19. Xu, Hongtao*; Ma, Fei*; Wang, Nan; Hou, Wei; Xiong, Huan; Lu, Fengping; Li, Jie; Wang, Shuyue; Ma, Peixiang; Yang, Guang#; Lerner, Richard A.#.DNA-Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On-DNA Suzuki, Sonogashira, and Buchwald Reactions.ADVANCED SCIENCE. 04 Dec 2019. 6(23):1901551.
- 20. Ma, Peixiang*; Xu, Hongtao*; Li, Jie*; Lu, Fengping; Ma, Fei; Wang, Shuyue; Xiong, Huan; Wang, Wei; Buratto, Damiano; Zonta, Francesco; Wang, Nan; Liu, Kaiwen; Hua, Tian; Liu, Zhi-Jie; Yang, Guang#; Lerner, Richard A.#.Functionality-Independent DNA Encoding of Complex Natural Products.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 01 Jul 2019. 58(27):9254-9261.
专著
1. H. Xu, P. Ma, G. Yang, Natural-Product-Enriched DELs, in: DNA-Encoded Libraries, Georg Thieme Verlag KG, Stuttgart, 2024: pp. 575–580. doi:10.1055/b000000342 2. W. Hou, G. Yang, H. Xu, On-DNA C—X (X=N, O, P, S, Se) Bond Forming Reactions, in: DNA- Encoded Libraries, Georg Thieme Verlag KG, Stuttgart, 2024: pp. 151–214. doi:10.1055/b000000342 3. H. Xu, W. Hou, Selenium-containing heterocycles, in: Privil. Scaffolds Drug Discov., Elsevier, 2023: pp. 915–930. doi:10.1016/B978-0-443-18611-0.00006-1 4. H. Xu, P. Ma, DNA Encoding of Natural Products, in: D. Israel, Y. Ding (Eds.), Methods Mol. Biol., Springer US, New York, NY, 2022: pp. 81–87. doi:10.1007/978-1-0716-2545-3_13
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