中文信息

代表性论文（*第一作者，#通讯作者）

1. Yao, Hebang; Wang, Hongyang; Zhang, Zhaoyong; Lu, Yuchi;* Zhang, Zhiying; Zhang, Yu; Xiong, Xinyi; Wang, Yanqun; Wang, Zhizhi; Yang, Haitao^#; Zhao, Jincun^#; Xu, Wenqing^#.A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains.MEDCOMM. 2023 Oct 26.
2. Wang, Hongyang*; Bienz, Mariann; Yan, Xiao-Xue^#; Xu, Wenqing^#; .Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.NATURE COMMUNICATIONS. 22 Jun 2023. 14(1).
3. Xu, Wenqing^#*; Velankar, Sameer^#; Patwardhan, Ardan; Hoch, Jeffrey C.; Burley, Stephen K.^#; Kurisu, Genji^#; .Announcing the launch of Protein Data Bank China as an Associate Member of the Worldwide Protein Data Bank Partnership.ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 01 Sep 2023. 79.
4. Tian, Li-Fei*; Gao, Hongwei; Yang, Shuyu; Liu, Yan-Ping; Li, Mingzhou; Xu, Wenqing^#; Yan, Xiao-Xue; .Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 31 Dec 2023. 253.
5. Pavic, Karolina*; Gupta, Nikhil; Omella, Judit Domenech; Derua, Rita; Aakula, Anna; Huhtaniemi, Riikka; Maatta, Juha A.; Hofflin, Nico; Okkeri, Juha; Wang, Zhizhi; Kauko, Otto; Varjus, Roosa; Honkanen, Henrik; Abankwa, Daniel; Kohn, Maja; Hytonen, Vesa P.; Xu, Wenqing; Nilsson, Jakob; Page, Rebecca; Janssens, Veerle; Leitner, Alexander; Westermarck, Jukka^#; .Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.NATURE COMMUNICATIONS;. 01 Dec 2023. 14(1).
6. Tian, Li-Fei*; Kuang, Xiaolin; Ding, Ke; Gao, Hongwei; Tang, Qun; Yan, Xiao-Xue^#; Xu, Wenqing^#; .Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023. 24(1).
7. Chen, Lianqi*; Liu, Yan-Ping; Tian, Li-Fei; Li, Mingzhou; Yang, Shuyu; Wang, Song; Xu, Wenqing^#; Yan, Xiao-Xue^#; .Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/beta-Catenin Signaling Pathway.BIOMOLECULES. 01 Apr 2023. 13(4).
8. Liu, Huisi*; Wu, Weiwei*; Sun, Gangyu*; Chia, Tiongsun*; Cao, Lei; Liu, Xiaodan; Guan, Jian; Fu, Fenggen; Yao, Ying; Wu, Zhihai; Zhou, Shuaixiang; Wang, Jie; Lu, Jia; Kuang, Zhihui; Wu, Min; He, Luan; Shao, Zhiyuan; Wu, Dongdong; Chen, Bingliang; Xu, Wenqing; Wang, Zhizhi^#; He, Kaijie^#; .Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.CELL REPORTS MEDICINE. 21 Jun 2022. 3(6).
9. Jia, Lina*; Liu, Yan-Ping; Tian, Li-Fei; Xiong, Chao; Xu, Xin; Qu, Honge; Xiong, Weixi; Zhou, Dong; Wang, Feng; Liu, Zheng; Yan, Xiao-Xue^#; Xu, Wenqing^#; Tang, Lin^#; .Potent neutralizing RBD-specific antibody cocktail against SARS-CoV-2 and its mutant.MEDCOMM. Sep 2021. 2(3):442-452.
10. Zhong, Qing*; Zhao, Yanyu; Ye, Fangfei; Xiao, Zaiyu; Huang, Gaoxingyu; Xu, Meng; Zhang, Yuanyuan; Zhan, Xiechao; Sun, Ke; Wang, Zhizhi; Cheng, Shanshan; Feng, Shan; Zhao, Xiuxiu; Zhang, Jizhong; Lu, Peilong; Xu, Wenqing; Zhou, Qiang^#; Ma, Dan^#; .Cryo-EM structure of human Wntless in complex with Wnt3a.NATURE COMMUNICATIONS. 27 Jul 2021. 12(1).
11. Zhao, Yao*; Du, Xiaoyu*; Duan, Yinkai*; Pan, Xiaoyan*; Sun, Yifang*; You, Tian*; Han, Lin*; Jin, Zhenming; Shang, Weijuan; Yu, Jing; Guo, Hangtian; Liu, Qianying; Wu, Yan; Peng, Chao; Wang, Jun; Zhu, Chenghao; Yang, Xiuna; Yang, Kailin; Lei, Ying; Guddat, Luke W.; Xu, Wenqing; Xiao, Gengfu; Sun, Lei^#; Zhang, Leike^#; Rao, Zihe^#; Yang, Haitao^#; .High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.PROTEIN & CELL. Nov 2021. 12(11):877-888.
12. Liu, Fengjiang*; Liang, Jingxi*; Zhang, Bing^#*; Gao, Yan*; Yang, Xiuna; Hu, Tianyu; Yang, Haitao; Xu, Wenqing; Guddat, Luke W.; Rao, Zihe^#; .Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC.SCIENCE ADVANCES. Oct 2020. 6(44):eabb9833.
13. Wang, Quan^#*; Wu, Jiqin*; Wang, Haofeng*; Gao, Yan*; Liu, Qiaojie*; Mu, An; Ji, Wenxin; Yan, Liming; Zhu, Yan; Zhu, Chen; Fang, Xiang; Yang, Xiaobao; Huang, Yucen; Gao, Hailong; Liu, Fengjiang; Ge, Ji; Sun, Qianqian; Yang, Xiuna; Xu, Wenqing; Liu, Zhijie; Yang, Haitao; Lou, Zhiyong; Jiang, Biao; Guddat, Luke W.; Gong, Peng^#; Rao, Zihe^#; .Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.CELL. 23 Jul 2020. 182(2):417.
14. 许文青*; 丛尧; 王权; .冷冻电镜:新时代蛋白质科学和药物研发的利器.张江科技评论;. 28 Jun 2020. 3:43-45.
15. Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan^#; Li, Jun^#; Besra, Gurdyal S.^#; Rao, Zihe^#; .Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
16. Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan^#; Lou, Zhiyong^#; Rao, Zihe^#; .Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
17. Zhang, Lu*; Zhao, Yao*; Gao, Ruogu*; Li, Jun; Yang, Xiuna; Gao, Yan; Zhao, Wei; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Besra, Kajelle Kaur; Xu, Wenqing; Bi, Lijun; Zhang, Xian'en; Guddat, Luke W.; Yang, Haitao; Wang, Quan^#; Besra, Gurdyal S.^#; Rao, Zihe^#; .Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2).PROTEIN & CELL. 03 May 2020. 11(7):505-517.
18. Jin, Zhenming*; Du, Xiaoyu*; Xu, Yechun*; Deng, Yongqiang*; Liu, Meiqin*; Zhao, Yao; Zhang, Bing; Li, Xiaofeng; Zhang, Leike; Peng, Chao; Duan, Yinkai; Yu, Jing; Wang, Lin; Yang, Kailin; Liu, Fengjiang; Jiang, Rendi; Yang, Xinglou; You, Tian; Liu, Xiaoce; Yang, Xiuna; Bai, Fang; Liu, Hong; Liu, Xiang; Guddat, Luke W.; Xu, Wenqing; Xiao, Gengfu; Qin, Chengfeng; Shi, Zhengli; Jiang, Hualiang^#; Rao, Zihe^#; Yang, Haitao^#; .Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors.NATURE. 09 Apr 2020. 582(7811):289–293.
19. Wang, Hongyang*; Kim, Juhyun; Wang, Zhizhi; Yan, Xiao-Xue^#; Dean, Ann^#; Xu, Wenqing^#; .Crystal structure of human LDB1 in complex with SSBP2.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. 117(2):1042-1048.
20. Ma, Dan*; Wang, Zhizhi; Merrikh, Christopher N.; Lang, Kevin S.; Lu, Peilong; Li, Xin; Merrikh, Houra; Rao, Zihe; Xu, Wenqing^#; .Crystal structure of a membrane-bound O-acyltransferase.NATURE. 11 Oct 2018. 562(7726):286-+.
21. Lu, Peilong*; Min, Duyoung; DiMaio, Frank; Wei, Kathy Y.; Vahey, Michael D.; Boyken, Scott E.; Chen, Zibo; Fallas, Jorge A.; Ueda, George; Sheffler, William; Mulligan, Vikram Khipple; Xu, Wenqing; Bowie, James U.; Baker, David^#; .Accurate computational design of multipass transmembrane proteins.SCIENCE. 2018. 359(6379):1042-1046.
22. DaRosa, Paul A.*; Wang, Zhizhi*; Jiang, Xiaomo; Pruneda, Jonathan N.; Cong, Feng; Klevit, Rachel E.^#; Xu, Wenqing^#; .Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.NATURE. 2015. 517(7533):223-U275.
23. Shen, Guobo*; Ke, Jiyuan*; Wang, Zhizhi; Cheng, Zhihong; Gu, Xin; Wei, Yuquan; Melcher, Karsten; Xu, H. Eric^#; Xu, Wenqing^#; .Structural basis of the Norrin-Frizzled 4 interaction.CELL RESEARCH. 2015. 25(9):1078-1081.
24. Sun, Wei*; Zhu, Ye Julia; Wang, Zhizhi; Zhong, Qiang; Gao, Feng; Lou, Jizhong; Gong, Weimin^#; Xu, Wenqing^#; .Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.NATURE COMMUNICATIONS. 2013. 4.
25. Wang, Zhizhi*; Michaud, Gregory A.; Cheng, Zhihong; Zhang, Yue; Hinds, Thomas R.; Fan, Erkang; Cong, Feng; Xu, Wenqing^#; .Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly (ADP-ribosyl)ation-dependent ubiquitination.GENES & DEVELOPMENT. 2012. 26(3):235-240.
26. Morrone, Seamus*; Cheng, Zhihong; Moon, Randall T.; Cong, Feng; Xu, Wenqing^#; .Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(5):1500-1505.
27. Cheng, Zhihong*; Biechele, Travis; Wei, Zhiyi; Morrone, Seamus; Moon, Randall T.; Wang, Liguo; Xu, Wenqing^#; .Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011. 18(11):1204.
28. Xu, Zheng*; Cetin, Bulent; Anger, Martin; Cho, Uhn Soo; Helmhart, Wolfgang; Nasmyth, Kim^#; Xu, Wenqing^#; .Structure and Function of the PP2A-Shugoshin Interaction.MOLECULAR CELL. 2009. 35(4):426-441.
29. Liu, Jing*; Phillips, Bryan T.; Amaya, Maria F.; Kimble, Judith^#; Xu, Wenqing^#; .The C. elegans SYS-1 protein is a bona fide beta-catenin.DEVELOPMENTAL CELL. 2008. 14(5):751-761.
30. Cho, Uhn Soo*; Xu, Wenqing^#; .Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.NATURE. 2007. 445(7123):53-57.
31. Cho, Uhn Soo*; Morrone, Seamus; Sablina, Anna A.; Arroyo, Jason D.; Hahn, William C.; Xu, Wenqing^#; .Structural basis of PP2A inhibition by small t antigen.PLOS BIOLOGY. 2007. 5(8):1810-1819.
32. Sampietro, James*; Dahlberg, Caroline L.; Cho, Uhn Soo; Hinds, Thomas R.; Kimelman, David; Xu, Wenqing^#; .Crystal structure of a beta-catenin/BCL9/Tcf4 complex.MOLECULAR CELL. 2006. 24(2):293-300.
33. Xing, Yi*; Clements, Wilson K.; Le Trong, Isolde; Hinds, Thomas R.; Stenkamp, Ronald; Kimelman, David; Xu, Wenqing^#; .Crystal structure of a beta-Catenin/APC complex reveals a critical role for APC phosphorylation in APC function.MOLECULAR CELL. 2004. 15(4):523-533.
34. Xing, Yi*; Clements, Wilson K.; Kimelman, David; Xu, Wenqing^#; .Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.GENES & DEVELOPMENT. 2003. 17(22):2753-2764.
35. Graham, Thomas A.*; Clements, Wilson K.; Kimelman, David; Xu, Wenqing^#; .The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.MOLECULAR CELL. 2002. 10(3):563-571.
36. Xu, Wenqing*; Harrison, Stephen C.; Eck, Michael J.^#; .Three-dimensional structure of the tyrosine kinase c-Src.NATURE. 1997. 385(6617):595-602.
37. Graham, Thomas A.*; Weaver, Carole; Mao, Feng; Kimelman, David; Xu, Wenqing^#; .Crystal structure of a beta-catenin/Tcf complex.CELL. 2000. 103(6):885-896.
38. Xu, Wenqing^#*; Rould, Mark A; Jun, Susie; Desplan, Claude; Pabo, Carl O; .CRYSTAL-STRUCTURE OF A PAIRED DOMAIN-DNA COMPLEX AT 2.5-ANGSTROM RESOLUTION REVEALS STRUCTURAL BASIS FOR PAX DEVELOPMENTAL MUTATIONS.CELL. 1995. 80(4):639-650.