英文信息

Principal investigator

Name:

Xin XieDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Materia Medica, CAS

Honor:

Education Background:

Working Experience:

Group Introduction

Research Area:

GPCR Pharmacological and Stem Cell-based Research

Research Interests:

1. The function of GPCR signaling in major diseases (autoimmune diseases, metabolic diseases, neurodegenerative diseases, etc) and drug discovery targeting GPCRs

2. Stem cell fate determination－a chemical biology approach

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Du, Changsheng*; Duan, Yanhui; Wei, Wei; Cai, Yingying; Chai, Hui; Lv, Jie; Du, Xiling; Zhu, Jian; Xie, Xin^#.Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.NATURE COMMUNICATIONS. 2016. 7.
2. Long, Yuan*; Wang, Min; Gu, Haifeng; Xie, Xin^#.Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells.CELL RESEARCH. 2015. 25(10):1171-1174.
3. Fu, Yanbin*; Huang, Chenwen; Xu, Xinxiu; Gu, Haifeng; Ye, Youqiong; Jiang, Cizhong; Qiu, Zilong; Xie, Xin^#.Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.CELL RESEARCH. 2015. 25(9):113-124.
4. Kong, Xiangqian*; Liu, Jian; Li, Lianchun; Yue, Liyan; Zhang, Lihong; Jiang, Hualiang; Xie, Xin^#; Luo, Cheng^#.Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition.NUCLEIC ACIDS RESEARCH. 2015. 43(9):4381-4392.
5. Zhang, Shuyong*; Ma, Yuyong; Li, Jing; Ma, Junjun; Yu, Biao^#; Xie, Xin^#.Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(40):14571-14576.
6. Chen, Guofang*; Xu, Xinxiu; Zhang, Lihong; Fu, Yanbin; Wang, Min; Gu, Haifeng; Xie, Xin^#.Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming.CELL RESEARCH. 2014. 24(9):1121-1136.
7. Xu, Xinxiu*; Wang, Quan; Long, Yuan; Zhang, Ru; Wei, Xiaoyuan; Xing, Mingzhe; Gu, Haifeng; Xie, Xin^#.Stress-mediated p38 activation promotes somatic cell reprogramming.CELL RESEARCH. 2013. 23(1):131-141.
8. Wang, Quan*; Xu, Xinxiu; Li, Jun; Liu, Jing; Gu, Haifeng; Zhang, Ru; Chen, Jiekai; Kuang, Yin; Fei, Jian; Jiang, Cong; Wang, Ping; Pei, Duanqing; Ding, Sheng; Xie, Xin^#.Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells.CELL RESEARCH. 2011. 21(10):1424-1435.
9. He, Xing*; Fang, Liyan; Wang, Jue; Yi, Yanghua; Zhang, Shuyu; Xie, Xin^#.Bryostatin-5 Blocks Stromal Cell-Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors.CANCER RESEARCH. 2008. 68(21):8678-8686.
10. Lin, Xi*; Li, Mingyue*; Wang, Niandong*; Wu, Yiran*; Luo, Zhipu; Guo, Shimeng; Han, Gye-Won; Li, Shaobai; Yue, Yang; Wei, Xiaohu; Xie, Xin; Chen, Yong; Zhao, Suwen; Wu, Jian^#; Lei, Ming^#; Xu, Fei^#.Structural basis of ligand recognition and self-activation of orphan GPR52.NATURE. 19 Feb 2020.

Xin Xie, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo