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Ying Xi, PhDAssistant Professor

Tel:

Email: xiying@@shanghaitech.edu.cn

Fax: 86-21-20685430

Add: 393 Middle Huaxia Road, Pudong, Shanghai

Faculty KMS Profile

中文信息English

Principal investigator

Name:

Ying XiAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:
  • 1999/09-2003/07, Nanjing University, BS
  • 2004/09-2010/03, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, PhD
Working Experience:
  • 2010/12-2016/07, University of California, San Francisco, Postdoctoral Researcher
  • 2016/07-2019/08, Genentech Inc., Senior Scientific Researcher
  • 2019/09-now, ShanghaiTech University, Assistant Professor (TENURE-TRACK), PI

Group Introduction

Research Area:
Lung Stem Cell, Regeneration and Lung Fibrosis
Research Interests:

Tissue fibrosis(scarring) occurs as a complication of many major human diseases and is a leading cause of morbidity and mortality worldwide. The 5-year survival rates for patients with progressive fibrotic diseases, e.g. idiopahtic pulmonary fibrosis(IPF) are worse than many types of cancer. However, fibrosis is poorly understood, and accordingly, IPF remains an urgent unmet medical need despite two FDA-approved therapies, each of which show limited efficacy.


Fibrotic scarring is often defined as a wound-healing response that has gone awry. The adult lung is a largely quiescent tissue, but it can respond robustly to injury to regenerate lost or damaged cells, by activating stem/progenitor populations or promoting surviving, mature lineages to re-enter the cell cycle. When this regenerative potential is disrupted or limited, fibrosis may occur. Therefore, understanding the reparative capacity of the lung and the regulation of resident stem/progenitor cells in response to tissue injury is of remarkable therapeutic interest.


Our lab uses in vitro and in vivo systems, including organoid culture, cell-lineage tracing, and fibrosis animal models, combined with transcriptome analysis to the characterize the molecular mechanisms that regulate stem/progenitor cell proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of fibrotic diseases.


Group Website:

Research Achievement

We identified a previously uncharacterized progenitor population in distal airway, named lineage-negative epithelial progenitors (LNEPs), which exhibit a binary response to reconstitute epithelial barriers: differentiating into Krt5pos basal-like cell or alveolar type II cells (AEC2s). Local lung hypoxia, via hypoxia inducible factor (HIF)1a, drives Notch signaling and Krt5pos basal-like cell expansion in mice and humans upon major lung injury, resulting in aberrant alveolar repair. Activated murine Krt5pos LNEPs and hypoxic human AEC2s up-regulate strikingly similar core pathways underlying migration and squamous metaplasia.  Increasing Wnt/beta-catenin activity in LNEPs attenuates Notch and Krt5 activation, favoring AEC2 differentiation. These findings implicate local lung hypoxia as a critical regulator of epithelial progenitors in response to lung injury and elucidate critical determinants of epithelial fate decisions governing the quality of alveolar repair. 

Figure 1. The alveolar repair pathways.


Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo

  • Name：Lu, Tiantian
    Position：Postdoc
    Duration：2020/07-Now
    Email：lutt@@shanghaitech.edu.cn
  • Name：Shen, Shengxi
    Position：Postgraduate Student
    Duration：2020/03-Now
    Email：shenshx@@shanghaitech.edu.cn
  • Name：Zhao, Peng
    Position：Postgraduate Student
    Duration：2020/03-2022/08
    Email：zhaopeng1@@shanghaitech.edu.cn
  • Name：Cao, Yiyuan
    Position：Postgraduate Student
    Duration：2020/03-Now
    Email：caoyy1@@shanghaitech.edu.cn
  • Name：Wu, Pei
    Position：Postgraduate Student
    Duration：2021/02-Now
    Email：wupei@@shanghaitech.edu.cn
  • Name：Liu, Li
    Position：Postgraduate Student
    Duration：2021/02-Now
    Email：liuli2@@shanghaitech.edu.cn
  • Name：Wu, Weijie
    Position：Postgraduate Student
    Duration：2021/02-Now
    Email：wuwj1@@shanghaitech.edu.cn
  • Name：Wei, Yuqi
    Position：Undergraduate Student
    Duration：2020/08-2023/07
    Email：weiyq1@@shanghaitech.edu.cn
  • Name：Chen, Zhe
    Position：Undergraduate Student
    Duration：2021/02-2023/07
    Email：chenzhe@@shanghaitech.edu.cn
  • Name：Sui, Yuandong
    Position：Postgraduate Student
    Duration：2022/02-Now
    Email：suiyd@shanghaitech.edu.cn
  • Name：Liu, Run
    Position：Postgraduate Student
    Duration：2022/02-Now
    Email：liurun@shanghaitech.edu.cn
  • Name：Xiwen He
    Position：Postgraduate Student
    Duration：03/2023-Now
    Email：hexw2022@shanghaitech.edu.cn
  • Name：Jiawei Chen
    Position：Postgraduate Student
    Duration：02/2023-Now
    Email：chenjw2022@shanghaitech.edu.cn
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