向阳飞, PhD助理教授研究员博士生导师

电话：

邮箱： xiangyf@@shanghaitech.edu.cn

传真：

地址：上海市浦东新区华夏中路393号

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中文信息English

干细胞与神经生物学研究组

课题组长

姓名：

向阳飞助理教授研究员博士生导师, PhD, 助理教授

职务：

所在院所：

生命科学与技术学院

荣誉称号：

教育经历：

2002/09—2006/06，怀化学院，学士
2006/09—2009/06，暨南大学，硕士
2009/09—2013/06，暨南大学，博士

博士后及工作经历：

2013/08—2019/05，耶鲁大学，博士后
2019/05—2020/02，耶鲁大学，副研究员
2020/03—至今，上海科技大学，生命科学与技术学院，助理教授 (TENURE-TRACK)

课题组简介

研究方向：

干细胞与神经类器官

研究内容：

1）神经类器官技术开发；

2）基于类器官技术的发育与疾病研究。

课题组网站：www.yxlab.org

欢迎生物背景、或生信背景的新成员加入我们课题组！

课题组网站：

研究成果展示

实验室聚焦脑类器官的精细构建、复合构建及其应用。利用人多能干细胞，我们已建立多种脑类器官原创模型与应用。

1）建立皮质、腹侧端脑类器官；构建多脑区复合类器官，模拟人类中间神经元迁移（Cell Stem Cell 2017）。

2）建立丘脑类器官；构建多脑区复合类器官，模拟丘脑与皮层间轴突投射连接（Cell Stem Cell 2019）。

3）基于细胞编程实现多谱系复合类器官构建，建立脑类器官血管化复合（Nature Methods 2019）。

4）利用干细胞体外分化、脑类器官等，研究神经发育疾病Rett Syndrome机制与药物靶点（Molecular Cell 2020）。

5）课题组采访介绍（Cell Stem Cell 2020）。

6）课题组采访介绍（Cell Stem Cell 2021）。

7）建立具备核团特征的腹侧丘脑类器官，模拟人脑核团特异的发育异常（Cell Stem Cell 2023）。

8）建立脊髓三叉神经核特异的脑类器官，建立脑核团相关的多脑区复合，模拟核团与靶区域的轴突连接（Cell Stem Cell 2024）。

9）基于共发育构建多组织复合类器官，建立自组织、共发育的神经、肌肉、骨骼三组织复合类器官模型（Cell Stem Cell 2025）。

课题研究相关关注报道。

开设课程：1）再生医学原理（本科生、研究生）

2）类脑器官（本科生）

参与课程：1）生物医学工程基础

2）实验生物学

代表性论文（*第一作者，#通讯作者）

1. Yin Y*, Zhou W, Zhu J, Chen Z, Jiang L, Zhuang X, Chen J, Wei J, Lu X, Liu Y, Pang W, Zhang Q, Cao Y, Li Z, Zhu Y, Xiang Y^#.Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells.Cell Stem Cell. 2025 Jan 2. 32(1):157-171.
2. Wei Pang*, Jinkui Zhu*, Kexin Yang, Xiaona Zhu, Wei Zhou, Linlin Jiang , Xuran Zhuang, Yantong Liu , Jianfeng Wei, Xiaoxiang Lu, Yao Yin, Ziling Chen, Yangfei Xiang^#.Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei.Cell Stem Cell. Aug 28 2024. S1934-5909(24)00290-X.
3. Kiral FR*, Cakir B, Tanaka Y, Kim J, Yang WS, Wehbe F, Kang YJ, Zhong M, Sancer G, Lee SH, Xiang Y^#, Park IH^#.Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Cell Stem Cell. 2023 Mar 28. 30(5):677-688.e5. DOI: 10.1016/j.stem.2023.03.007.
4. Barral, Serena^#*; Xiang, Yangfei^#; Birey, Fikri^#; .Improving in vitro modeling of human brain with future brain organoids.FRONTIERS IN MOLECULAR NEUROSCIENCE. 09 Aug 2022. 15.
5. Lu, Xiaoxiang*; Yang, Jiajie; Xiang, Yangfei; .Modeling human neurodevelopmental diseases with brain organoids.CELL REGENERATION. Jan 2022. 11(1).
6. Anastasia Tikhonova^#*; Yangfei Xiang^#*; Casey Gifford^#*; .Early-career researchers in the time of COVID-19: Starting a new lab during a pandemic.CELL STEM CELL. 06 May 2021.
7. Xiang, Yangfei*; .Human brain organoids: development and application.CANCER SCIENCE. 01 Feb 2022. 113.
8. Yoshiaki Tanaka*; Bilal Cakir; Yangfei Xiang; Gareth J. Sullivan; In-Hyun Park^#; .Synthetic Analyses of Single-Cell Transcriptomes From Multiple Brain Organoids and Fetal Brain.CELL REPORTS. 2020. 30(6):1682-1689.
9. Smith, Quinton^#*; McKinley, Kara L.^#*; Chan, Chii Jou^#*; Sikandar, Shaheen^#*; Xiang, Yangfei^#*; Passaro, Diana^#*; .Introductions to the Community: Early-Career Researchers in the Time of COVID-19.CELL STEM CELL. 05 Nov 2020. 27(5):702-704.
10. Lim, Yolpanhchana*; Beane-Ebel, Jennifer E.; Tanaka, Yoshiaki; Ning, Boting; Husted, Christopher R.; Henderson, David C.; Xiang, Yangfei; Park, In-Hyun; Farrer, Lindsay A.; Zhang, Huiping^#; .Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.TRANSLATIONAL PSYCHIATRY. 02 Oct 2021. 11(1).
11. Xiang, Yangfei*; Tanaka, Yoshiaki*; Patterson, Benjamin; Hwang, Sung-Min; Hysolli, Eriona; Cakir, Bilal; Kim, Kun-Yong; Wang, Wanshan; Kang, Young-Jin; Clement, Ethan M.; Zhong, Mei; Lee, Sang-Hun; Cho, Yee Sook; Patra, Prabir; Sullivan, Gareth J.; Weissman, Sherman M.; Park, In-Hyun^#; .Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.MOLECULAR CELL. 2020. 79(1):84-+.
12. Xiang, Yangfei^#*; Cakir, Bilal; Park, In-Hyun^#; .Deconstructing and reconstructing the human brain with regionally specified brain organoids.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. Mar 2021. 111:40-51.
13. Cakir, Bilal*; Xiang, Yangfei*; Tanaka, Yoshiaki; Kural, Mehmet H.; Parent, Maxime; Kang, Young-Jin; Chapeton, Kayley; Patterson, Benjamin; Yuan, Yifan; He, Chang-Shun; Raredon, Micha Sam B.; Dengelegi, Jake; Kim, Kun-Yong; Sun, Pingnan; Zhong, Mei; Lee, Sangho; Patra, Prabir; Hyder, Fahmeed; Niklason, Laura E.; Lee, Sang-Hun; Yoon, Young-Sup; Park, In-Hyun^#; .Engineering of human brain organoids with a functional vascular-like system.NATURE METHODS. 2019. 16(11):1169.
14. Xiang, Yangfei^#*; Bilal Cakir; In-Hyun Park; .Generation of regionally specified human brain organoids resembling thalamus development.CELL PRESS: STAR PROTOCOLS. 2019.
15. Xiang, Yangfei*; Tanaka, Yoshiaki*; Cakir, Bilal; Patterson, Benjamin; Kim, Kun-Yong; Sun, Pingnan; Kang, Young-Jin; Zhong, Mei; Liu, Xinran; Patra, Prabir; Lee, Sang-Hun; Weissman, Sherman M.; Park, In-Hyun^#; .hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.CELL STEM CELL. 2019. 24(3):487.
16. Xiang, Yangfei*; Tanaka Yoshiaki; Benjamin Patterson; Bilal Cakir; Kun-Yong Kim; Yee Sook Cho; In-Hyun Park^#; .Generation and fusion of human cortical and medial ganglionic eminence brain organoids.CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2018.
17. Kim, Kun-Yong*; Tanaka, Yoshiaki; Su, Juan; Cakir, Bilal; Xiang, Yangfei; Patterson, Benjamin; Ding, Junjun; Jung, Yong-Wook; Kim, Ji-Hyun; Hysolli, Eriona; Lee, Haelim; Dajani, Rana; Kim, Jonghwan; Zhong, Mei; Lee, Jeong-Heon; Skalnik, David; Lim, Jeong Mook; Sullivan, Gareth J.; Wang, Jianlong; Park, In-Hyun^#; .Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.NATURE COMMUNICATIONS. 2018. 9.
18. Xiang, Yangfei*; Tanaka, Yoshiaki*; Patterson, Benjamin; Kang, Young-Jin; Govindaiah, Gubbi; Roselaar, Naomi; Cakir, Bilal; Kim, Kun-Yong; Lombroso, Adam P.; Hwang, Sung-Min; Zhong, Mei; Stanley, Edouard G.; Elefanty, Andrew G.; Naegele, Janice R.; Lee, Sang-Hun; Weissman, Sherman M.; Park, In-Hyun^#; .Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.CELL STEM CELL. 2017. 21(3):383.
19. Xiang, Yangfei*; Kim, Kun-Yong; Gelernter, Joel; Park, In-Hyun^#; Zhang, Huiping^#; .Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons.PLOS ONE. 2015. 10(8).
20. Tanaka, Yoshiaki*; Hysolli, Eriona; Su, Juan; Xiang, Yangfei; Kim, Kun-Yong; Zhong, Mei; Li, Yumei; Heydari, Kartoosh; Euskirchen, Ghia; Snyder, Michael P.; Pan, Xinghua; Weissman, Sherman Morton; Park, In-Hyun^#; .Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.STEM CELL REPORTS. 2015. 4(6):1125-1139.