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Yangfei Xiang, PhDAssistant Professor

Tel:

Email: xiangyf@@shanghaitech.edu.cn

Fax: 86-21-20685430

Add: 393 Middle Huaxia Road, Pudong, Shanghai

Faculty KMS Profile

中文信息English

Principal investigator

Name:

Yangfei XiangAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:
  • 2002/09-2006/06, Huaihua University, B.S.
  • 2006/09-2009/06, Jinan University, M.S.
  • 2009/09-2013/06, Jinan Universit, Ph.D.
Working Experience:
  • 2013/08-2019/05, Yale University, Postdoctoral Fellow
  • 2019/05-2020/02, Yale University, Associate Research Scientist
  • 2020/03-Present, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)

Group Introduction

Research Area:
Stem Cell and Neurobiology, Organoids
Research Interests:

The human being started to quest the mysteries of the brain a long time ago, yet today many puzzles remain unsolved. Thanks to the knowledge in current stem cell biology, developmental biology, and many others, now we can build 3D models of the human brain in a dish. These models, named as brain organoids, are 3D neural cultures capable of recapitulating the spatiotemporal organization and function of the brain. Brain organoids provide easy access to deciphering the human brain in a dish, which otherwise could be hard to achieve. 

At Xiang Lab, we explore the human brain organoid toolkits. By combining with more stem cell technologies, particularly genome editing, we apply brain organoids to understand the etiology and therapy of human neurological disorders. We aim to both address fundamental questions in human brain research and serve the urgent needs in medicine. Learn more about our lab and join us in bringing about more positive changes.

Lab website: www.yxlab.org 
Group Website:

Research Achievement

From human pluripotent stem cells (hESCs and hiPSCs), we have achieved regional specifications of human brain organoids, deciphered the differential development programs in various regions of the human brain, and applied region-specific human brain organoids for disease modeling. By fusing distinct region-specific brain organoids, we can reconstruct the regional interactions and connections inside the brain in a dish.

Figure 1. Modeling human brain development and interneuron migration 

with regionally specified brain organoids (Cell Stem Cell 2017).

Figure 2. Modeling reciprocal projections between human cerebral cortex and thalamus 

with regionally specified brain organoids (Cell Stem Cell 2019).

Figure 3. Vascularization of human brain organoids (Nature Methods 2019).

Figure 4. Genetically engineered two-dimensional and tri-dimensional human brain models 

reveal novel mechanisms and therapeutic opportunities for Rett Syndrome (Molecular Cell 2020).


Courses: 1) Principles of Regenerative Medicine (Undergrad and grad students)

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo

  • Name：Xuran Zhuang
    Position：Research Assistant Professor
    Duration：2021/09-now
    Email：
  • Name：Linlin Jiang
    Position：Doctoral Student
    Duration：2020/02-Now
    Email：
  • Name：Jianfeng Wei
    Position：Doctoral Student
    Duration：2020/02-Now
    Email：
  • Name：Wei Zhou
    Position：Doctoral Student
    Duration：2020/02-Now
    Email：
  • Name：Yantong Liu
    Position：Postgraduate Student
    Duration：2021/01-Now
    Email：
  • Name：Xiaoxiang Lu
    Position：Postgraduate Student
    Duration：2021/01-Now
    Email：
  • Name：Wei Pang
    Position：Postgraduate Student
    Duration：2021/01-Now
    Email：
  • Name：Xuanqian Tan
    Position：Undergraduate Student
    Duration：2020/07-Now
    Email：
  • Name：Yuyan Zhu
    Position：Undergraduate Student
    Duration：2020/08-Now
    Email：
  • Name：Jiajie Yang
    Position：Undergraduate Student
    Duration：2020/08-Now
    Email：
  • Name：Yao Yin
    Position：Postgraduate Student
    Duration：2022/01-Now
    Email：
  • Name：jinkui Zhu
    Position：Postgraduate Student
    Duration：2022/01-Now
    Email：
  • Name：Zhuoya Li
    Position：Undergraduate Student
    Duration：2022/08-Now
    Email：
  • Name： Ziling Chen
    Position：Postgraduate Student
    Duration：2023/01-Now
    Email：
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