Principal investigator
Name:
Haitao YangProfessor , PhD, Professor
Position:
Executive Director
Affiliation:
School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Institute
Honor:
Education Background:
- 1997-2001, Sichuan University, B.S.
- 2001-2006, Tsinghua University, Ph. D.
Working Experience:
- 2006-2011, Yale University, Postdoctoral Fellow
- 2011-2013, Yale University, Associate Research Scientist
- 2013-2017, Tianjin University, Full Professor & Vice Dean of School of Life Sciences
- 2018-present, ShanghaiTech University, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), Research Professor/Deputy Director/Executive Director
- 2018-2022/11, ShanghaiTech University, School of Life Science and Technology, Associate Professor
- 2022/11-Present, ShanghaiTech University, School of Life Science and Technology, Professor(TENURED)
Group Introduction
Research Area:
Infection and Anti-infection
Research Interests:
Viruses are significant pathogens involved in human diseases throughout human history. Many of these virus-related human diseases have zoonotic origins, such as AIDS, bird flu, and severe acute respiratory syndrome (SARS). We focus on the essential stages of the viral life cycle: cellular entry, replication and transcription of the viral genome, and virion assembly and release to identify the pivotal targets for drug development.
To study the underlying mechanisms of interplay between viruses and their hosts will also help reveal new drug targets. Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Interestingly, the viruses have evolved a variety of strategies to antagonize host restriction and escape the innate immune response. The interaction between host antiviral proteins and viral antagonizing proteins constitutes a dynamic and sophisticated network. Thus, strategies that boost the roles of host restriction while diminishing viral antagonism may lead to new therapies against viral infection.
Representative Publications (*First Author, # Corresponding Author)
- 1. Haofeng Wang*; Xiaoce Liu*; Xiang Zhang*; Zhuoqian Zhao*; Yuchi Lu*; Dingzhe Pu; Zeyang Zhang; Jie Chen; Yajie Wang; Mengfei Li; Xuxue Dong; Yinkai Duan; Yujia He; Qiyu Mao; Hangtian Guo; Haoran Sun; Yihan Zhou; Qi Yang; Yan Gao; Xiuna Yang; Hongzhi Cao; Luke Guddat; Lei Sun#; Zihe Rao#; Haitao Yang#;.TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.CELL. 21 Jun 2024.
- 2. Wen Cui*, Yinkai Duan*, Yan Gao*, Wei Wang#, Haitao Yang#.Structural review of SARS-CoV-2 antiviral targets.Structure. 5 Sep 2024. 32(9):1301-1321(invited review).
- 3. Xiaolin Yang#*; Tianyu Hu*; Jingxi Liang; Zhiqi Xiong; Zhenli Lin; Yao Zhao; Xiaoting Zhou; Yan Gao; Shan Sun; Xiuna Yang; Luke W. Guddat; Haitao Yang#; Zihe Rao#; Bing Zhang #; .An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality.NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 28 Mar 2024.
- 4. Duan, Yinkai*; Zhou, Hao; Liu, Xiang; Iketani, Sho; Lin, Mengmeng; Zhang, Xiaoyu; Bian, Qucheng; Wang, Haofeng; Sun, Haoran; Hong, Seo Jung; Culbertson, Bruce; Mohri, Hiroshi; Luck, Maria I.; Zhu, Yan; Liu, Xiaoce; Lu, Yuchi; Yang, Xiuna; Yang, Kailin; Sabo, Yosef; Chavez, Alejandro; Goff, Stephen P.; Rao, Zihe; Ho, David D.#; Yang, Haitao#; .Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.NATURE. 11 Sep 2023.
- 5. Wang, Haofeng*; Yang, Qi*; Liu, Xiaoce*; Xu, Zili*; Shao, Maolin*; Li, Dongxu; Duan, Yinkai; Tang, Jielin; Yu, Xianqiang; Zhang, Yumin; Hao, Aihua; Wang, Yajie; Chen, Jie; Zhu, Chenghao; Guddat, Luke; Chen, Hongli; Zhang, Leike#; Chen, Xinwen#; Jiang, Biao#; Sun, Lei#; Rao, Zihe; Yang, Haitao#; .Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.NATURE COMMUNICATIONS. 21 Nov 2023. 14(1).
- 6. Duan, Yinkai*; Wang, Haofeng; Yuan, Zhenghong#; Yang, Haitao#; .Structural biology of SARS-CoV-2 Mpro and drug discovery.CURRENT OPINION IN STRUCTURAL BIOLOGY. 04 Aug 2023. 82(102667).
- 7. Iketani, Sho*; Mohri, Hiroshi*; Culbertson, Bruce*; Hong, Seo Jung*; Duan, Yinkai; Luck, Maria, I; Annavajhala, Medini K.; Guo, Yicheng; Sheng, Zizhang; Uhlemann, Anne-Catrin; Goff, Stephen P.; Sabo, Yosef; Yang, Haitao; Chavez, Alejandro#; Ho, David D.#; .Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir.NATURE. 09 Nov 2022.
- 8. Yao Zhao#*; Yan Zhu*; Xiang Liu*; Zhenming Jin; Yinkai Duan; Qi Zhang; Chengyao Wu; Lu Feng; Xiaoyu Du; Jinyi Zhao; Maolin Shao; Bing Zhang; Xiuna Yang; Lijie Wu; Xiaoyun Ji; Luke W. Guddat; Kailin Yang; Zihe Rao#; Haitao Yang#; .Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 19 Apr 2022. 119(16).
- 9. Wang, Haofeng*; Xiao, Yunjie; Chen, Xia; Zhang, Mengwen; Sun, Guangxin; Wang, Feng; Wang, Lin; Zhang, Hanxiao; Zhang, Xiaoyu; Yang, Xin; Li, Wenling; Wei, Yi; Yao, Deqiang; Zhang, Bing; Li, Jun; Cui, Wen; Wang, Fenghua; Chen, Cheng; Shen, Wei; Su, Dan; Bai, Fang; Huang, Jinhai; Ye, Sheng; Zhang, Lei; Ji, Xiaoyun; Wang, Wei#; Wang, Zefang#; Hochstrasser, Mark#; Yang, Haitao#; .Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.NATURE COMMUNICATIONS. 25 Mar 2022. 13(1):1608.
- 10. Hangtian Guo*; Yan Gao*; Tinghan Li*; Tingting Li*; Yuchi Lu*; Le Zheng; Yue Liu; Tingting Yang; Feiyang Luo; Shuyi Song; Wei Wang; Xiuna Yang; Henry C. Nguyen; Hongkai Zhang; Ailong Huang#; Aishun Jin#; Haitao Yang#; Zihe Rao#; Xiaoyun Ji#; .Structures of Omicron Spike complexes and implications for neutralizing antibody development.CELL REPORTS. 03 May 2022.
- 11. Wang, Wei#*; Cui, Wen; Yang, Haitao#; .Toward an accurate mechanistic understanding of Wolbachia-induced cytoplasmic incompatibility (Invited Review).ENVIRONMENTAL MICROBIOLOGY. Oct 2022.
- 12. Lu Lu*; Su Shan; Yang Haitao#; Jiang Shibo#; .Antivirals with common targets against highly pathogenic viruses.CELL. 18 Mar 2021. 184(6):1604-1620.
- 13. Haitao Yang#*; Zihe Rao#; .Structural biology of SARS-CoV-2 and implications for therapeutic development.NATURE REVIEWS MICROBIOLOGY. Nov 2021.
- 14. Xiao, Yunjie*; Chen, Hongli; Wang, Haofeng; Zhang, Mengwen; Chen, Xia; Berk, Jason M.; Zhang, Lilin; Wei, Yi; Li, Wenling; Cui, Wen; Wang, Fenghua; Wang, Qianfan; Cui, Can; Li, Ting; Chen, Cheng; Ye, Sheng; Zhang, Lei; Ji, Xiaoyun; Huang, Jinhai; Wang, Wei#; Wang, Zefang#; Hochstrasser, Mark#; Yang, Haitao#; .Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 12 Oct 2021. 118(41).
- 15. Cui,Wen*; Braun,Elisabeth*; Wang,Wei*; Tang,Jinhong*; Zheng,Yanyan*; Slater,Benjamin; Li,Na; Chen,Cheng; Liu,Qingxiang; Wang,Bin; Li,Xiu; Duan,Yinkai; Xiao,Yunjie; Ti,Rujiao; Hotter,Dominik; Ji,Xiaoyun; Zhang,Lei; Cui,Jun; Xiong,Yong; Sauter,Daniel#; Wang,Zefang#; Kirchhoff,Frank#; Yang,Haitao#; .Structural basis for GTP-induced dimerization and antiviral functioin of guanylate-binding proteins.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 13 Apr 2021. 118(15).
- 16. Li Tingting*; Han Xiaojian*; Gu Chenjian*; Guo Hangtian*; Zhang Huajun; Wang Yingming; Hu Chao; Wang Kai; Liu Fengjiang; Luo Feiyang; Zhang Yanan; Hu Jie; Wang Wang; Li Shenglong; Hao Yanan; Shen Meiying; Huang Jingjing; Long Yingyi; Song Shuyi; Wu Ruixin; Mu Song; Chen Qian; Gao Fengxia; Wang Jianwei; Long Shunhua; Li Luo; Wu Yang; Gao Yan; Xu Wei; Cai Xia; Qu Di; Zhang Zherui; Zhang Hongqing; Li Na; Gao Qingzhu; Zhang Guiji; He Changlong; Wang Wei; Ji Xiaoyun; Tang Ni; Yuan Zhenghong; Xie Youhua#; Yang Haitao#; Zhang Bo#; Huang Ailong#; Jin Aishun#; .Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.NATURE COMMUNICATIONS. 02 Nov 2021. 12(1):6304.
- 17. Amporndanai, Kangsa*; Meng, Xiaoli; Shang, Weijuan; Jin, Zhenmig; Zhao, Yao; Rao, Zihe; Liu, Zhi-Jie; Yang, Haitao#; Zhang, Leike#; O'Neill, Paul M.#; Hasnain, S. Samar#; Rogers, Michael; .Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.NATURE COMMUNICATIONS. 24 May 2021. 12(1).
- 18. Jin, Zhenming*; Du, Xiaoyu*; Xu, Yechun*; Deng, Yongqiang*; Liu, Meiqin*; Zhao, Yao; Zhang, Bing; Li, Xiaofeng; Zhang, Leike; Peng, Chao; Duan, Yinkai; Yu, Jing; Wang, Lin; Yang, Kailin; Liu, Fengjiang; Jiang, Rendi; Yang, Xinglou; You, Tian; Liu, Xiaoce; Yang, Xiuna; Bai, Fang; Liu, Hong; Liu, Xiang; Guddat, Luke W.; Xu, Wenqing; Xiao, Gengfu; Qin, Chengfeng; Shi, Zhengli; Jiang, Hualiang#; Rao, Zihe#; Yang, Haitao#; .Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors.NATURE. 09 Apr 2020. 582(7811):289–293.
- 19. Dai, Wenhao*; Zhang, Bing*; Jiang, Xia-Ming*; Su, Haixia*; Li, Jian; Zhao, Yao; Xie, Xiong; Jin, Zhenming; Peng, Jingjing; Liu, Fengjiang; Li, Chunpu; Li, You; Bai, Fang; Wang, Haofeng; Cheng, Xi; Cen, Xiaobo; Hu, Shulei; Yang, Xiuna; Wang, Jiang; Liu, Xiang; Xiao, Gengfu; Jiang, Hualiang; Rao, Zihe; Zhang, Lei-Ke#; Xu, Yechun#; Yang, Haitao#; Liu, Hong#; .Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.SCIENCE. 19 Jun 2020. 368(6497):1331-1335.
- 20. Jin, Zhenming*; Zhao, Yao*; Sun, Yuan*; Zhang, Bing; Wang, Haofeng; Wu, Yan; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Du, Xiaoyu; Duan, Yinkai; Yu, Jing; Yang, Xiaobao; Yang, Xiuna; Yang, Kailin; Liu, Xiang; Guddat, Luke W.; Xiao, Gengfu; Zhang, Leike#; Yang, Haitao#; Rao, Zihe; .Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Jun 2020. 27(6):529-532.
- 21. Wang, Quan#*; Wu, Jiqin*; Wang, Haofeng*; Gao, Yan*; Liu, Qiaojie*; Mu, An; Ji, Wenxin; Yan, Liming; Zhu, Yan; Zhu, Chen; Fang, Xiang; Yang, Xiaobao; Huang, Yucen; Gao, Hailong; Liu, Fengjiang; Ge, Ji; Sun, Qianqian; Yang, Xiuna; Xu, Wenqing; Liu, Zhijie; Yang, Haitao; Lou, Zhiyong; Jiang, Biao; Guddat, Luke W.; Gong, Peng#; Rao, Zihe#; .Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.CELL. 23 Jul 2020. 182(2):417.
- 22. Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan#; Lou, Zhiyong#; Rao, Zihe#; .Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
- 23. Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan#; Li, Jun#; Besra, Gurdyal S.#; Rao, Zihe#; .Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
- 24. Zhang, Bing*; Li, Jun#*; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W.; Yang, Haitao#; Rao, Zihe#; .Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.CELL. 24 Jan 2019. 176(3):636-+.
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