生命科学与技术学院

上海科技大学

钟桂生, PhD副教授研究员博士生导师

电话：

邮箱： zhongsh@@shanghaitech.edu.cn

传真： 86-21-20685430

地址：上海市浦东新区华夏中路393号

KMS个人画像

中文信息English

基因治疗

课题组长

姓名：

钟桂生副教授研究员博士生导师, PhD, 副教授

职务：

所在院所：

生命科学与技术学院、iHuman研究所

荣誉称号：

教育经历：

1995/09—1999/07，安徽大学，学士
1999/09—2002/07，中国科学技术大学，硕士
2002/09—2007/05，美国康奈尔大学，博士

博士后及工作经历：

2007/06—2010/07，美国康奈尔大学，博士后
2010/07—2015/01，美国哈佛大学，研究助理
2015/01—2020/08，上海科技大学，生命科学与技术学院、iHuman研究所，助理教授（TENURE-TRACK）
2017/01—至今，上海科技大学，iHuman研究所，助理所长
2020/08—至今，上海科技大学，生命科学与技术学院、iHuman研究所，副教授（TENURED）

课题组简介

研究方向：

AAV改造，耳聋基因治疗

研究内容：

本课题组发展和优化新型腺相关病毒（AAV)，开发基因治疗在耳聋、视觉遗传性疾病以及神经系统疾病领域的应用。课题组结合病毒改造、分子生物学、单分子成像、超分辨显微成像、电生理等方法具体研究耳蜗的结构和功能。课题组注重和医院合作研究疾病的发病机制及探索可能的治疗手段。

课题组网站：

zhonglab.shanghaitech.edu.cn

研究成果展示

代表性论文（*第一作者，#通讯作者）

1. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng^#.Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 11 Nov 2020. 11(1).
2. Tan, Fangzhi^#*; Chu, Cenfeng; Qi, Jieyu; Li, Wenyan; You, Dan; Li, Ke; Chen, Xin; Zhao, Weidong; Cheng, Cheng; Liu, Xiaoyi; Qiao, Yunbo; Su, Bing; He, Shuijin; Zhong, Chao; Li, Huawei^#; Chai, Renjie^#; Zhong, Guisheng^#.AAV-ie enables safe and efficient gene transfer to inner ear cells.NATURE COMMUNICATIONS. 19 Aug 2019. 10.
3. Lan, Yiyang*; Tao, Yong; Wang, Yunfeng; Ke, Junzi; Yang, Qiuxiang; Liu, Xiaoyi; Su, Bing; Wu, Yiling; Lin, Chao-Po; Zhong, Guisheng^#.Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY. 18 May 2020.
4. Qiao, Yunbo^#*; Wang, Zejian*; Tan, Fangzhi*; Chen, Jun*; Lin, Jianxiang; Yang, Jie; Li, Hui; Wang, Xiongjun; Sali, Andrej; Zhang, Liye^#; Zhong, Guisheng^#.Enhancer Reprogramming within Pre-existing Topologically Associated Domains Promotes TGF-beta-Induced EMT and Cancer Metastasis.MOLECULAR THERAPY. 02 Sep 2020. 28(9):2083-2095.
5. Liu, Yan*; Qi, Jieyu*; Chen, Xin*; Tang, Mingliang*; Chu, Cenfeng; Zhu, Weijie; Li, Hui; Tian, Cuiping; Yang, Guang; Zhong, Chao; Zhang, Ying; Ni, Guangjian; He, Shuijin^#; Chai, Renjie^#; Zhong, Guisheng^#.Critical role of spectrin in hearing development and deafness.SCIENCE ADVANCES. Apr 2019. 5(4).
6. Chen, Xiaoyu*; Xu, Yueming; Qu, Lu; Wu, Lijie; Han, Gye Won; Guo, Yu; Wu, Yiran; Zhou, Qingtong; Sun, Qianqian; Chu, Cenfeng; Yang, Jie; Yang, Liu; Wang, Quan; Yuan, Shuguang; Wang, Ling; Hu, Tao; Tao, Houchao; Sun, Yaping; Song, Yunpeng; Hu, Liaoyuan; Liu, Zhi-Jie; Stevens, Raymond C.; Zhao, Suwen^#; Wu, Dong^#; Zhong, Guisheng^#.Molecular Mechanism for Ligand Recognition and Subtype Selectivity of alpha(2C) Adrenergic Receptor.CELL REPORTS. 03 Dec 2019. 29(10):2936-+.
7. Qi, Jieyu*; Liu, Yan; Chu, Cenfeng; Chen, Xin; Zhu, Weijie; Shu, Yilai; He, Shuijin^#; Chai, Renjie^#; Zhong, Guisheng^#.A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.CELL DISCOVERY. 19 Feb 2019. 5.
8. Zhang, Bingjie*; Zhao, Simeng; Yang, Dehua; Wu, Yiran; Xin, Ye; Cao, Haijie; Huang, Xi-Ping; Cai, Xiaoqing; Sun, Wen; Ye, Na; Xu, Yueming; Peng, Yao; Zhao, Suwen; Liu, Zhi-Jie; Zhong, Guisheng^#; Wang, Ming-Wei^#; Shui, Wenqing^#.A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts.ACS CENTRAL SCIENCE. 26 Feb 2020. 6(2):213-225.
9. Xu, Ke*; Zhong, Guisheng; Zhuang, Xiaowei^#.Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons.SCIENCE. 2013. 339(6118):452-456.
10. Zhong, Guisheng*; Sharma, Kamal; Harris-Warrick, Ronald M.^#.Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.NATURE COMMUNICATIONS. 2011. 2.
11. Qu, Lu*; Zhou, Qingtong; Xu, Yueming; Guo, Yu; Chen, Xiaoyu; Yao, Deqiang; Han, Gye Won; Liu, Zhi-Jie; Stevens, Raymond C.; Zhong, Guisheng^#; Wu, Dong^#; Zhao, Suwen^#.Structural Basis of the Diversity of Adrenergic Receptors.CELL REPORTS. 03 Dec 2019. 29(10):2929-+.
12. Fan, Ke-qi*; Li, Yi-yuan; Wang, Hao-li; Mao, Xin-tao; Guo, Jin-xin; Wang, Fei; Huang, Ling-jie; Li, Yi-ning; Ma, Xiang-yu; Gao, Zheng-jun; Chen, Wei; Qian, Dan-dan; Xue, Wen-jin; Cao, Qian; Zhang, Lei; Shen, Li; Zhang, Long; Tong, Chao; Zhong, Jiang-yan; Lu, Wei; Lu, Ling; Ren, Ke-ming; Zhong, Guisheng; Wang, Yuan; Tang, Mingliang; Feng, Xin-hua; Chai, Ren-jie^#; Jin, Jin^#.Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.CELL. 31 Oct 2019. 179(4):864-+.
13. Zhao, Yanan*; Wu, Xuanyuan; Chen, Xin; Li, Jianan; Tian, Cuiping; Chen, Jiangrui; Xiao, Cheng; Zhong, Guisheng^#; He, Shuijin^#.Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury.ISCIENCE. 21 Feb 2020. 23(2).
14. Shim, Sang-Hee*; Xia, Chenglong; Zhong, Guisheng; Babcock, Hazen P.; Vaughan, Joshua C.; Huang, Bo; Wang, Xun; Xu, Cheng; Bi, Guo-Qiang^#; Zhuang, Xiaowei^#.Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(35):13978-13983.
15. Zhong, Guisheng*; Shevtsova, Natalia A.; Rybak, Ilya A.; Harris-Warrick, Ronald M.^#.Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization.JOURNAL OF PHYSIOLOGY-LONDON. 2012. 590(19):4735-4759.
16. Zhong, Guisheng*; Droho, Steven; Crone, Steven A.; Dietz, Shelby; Kwan, Alex C.; Webb, Watt W.; Sharma, Kamal; Harris-Warrick, Ronald M.^#.Electrophysiological Characterization of V2a Interneurons and Their Locomotor-Related Activity in the Neonatal Mouse Spinal Cord.JOURNAL OF NEUROSCIENCE. 2010. 30(1):170-182.
17. Crone, Steven A.*; Zhong, Guisheng; Harris-Warrick, Ronald^#; Sharma, Kamal^#.In Mice Lacking V2a Interneurons, Gait Depends on Speed of Locomotion.JOURNAL OF NEUROSCIENCE. 2009. 29(21):7098-7109.
18. Yu, Jing*; Liu, Zaizhou; Liang, Yuanyuan; Luo, Feng; Zhang, Jie; Tian, Cuiping; Motzik, Alex; Zheng, Mengmeng; Kang, Jingwu; Zhong, Guisheng; Liu, Cong; Fang, Pengfei; Guo, Min; Razin, Ehud^#; Wang, Jing^#.Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.NATURE COMMUNICATIONS. 11 Oct 2019. 10.
19. Hao, Kaili*; Lei, Wei; Wu, Hongchun; Wu, Jie; Yang, Zhuangzhuang; Yan, Shiping; Lu, Xing-Ai; Li, Jingjing; Xia, Xue; Han, Xinglong; Deng, Wenbo; Zhong, Guisheng; Zhao, Zhen-Ao; Hu, Shijun^#.LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.THERANOSTICS. 2019. 9(24):7282-7297.
20. An, Bolin*; Wang, Xinyu; Cui, Mengkui; Gui, Xinrui; Mao, Xiuhai; Liu, Yan; Li, Ke; Chu, Cenfeng; Pu, Jiahua; Ren, Susu; Wang, Yanyi; Zhong, Guisheng; Lu, Timothy K.; Liu, Cong; Zhong, Chao^#.Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.ACS NANO. Jul 2017. 11(7):6985-6995.
21. Peng Yao*; Zhao Simeng; Wu Yiran; Cao Haijie; Xu Yueming; Liu Xiaoyan; Shui Wenqing; Cheng Jianjun; Zhao Suwen; Shen Ling; Ma Jun; Quinn Ronald J; Raymond C. Stevens; Zhong Guisheng; Liu Zhijie.Identification of natural products as novel ligands for the human 5-HT_(2C) receptor.BIOPHYSICS REPORTS. 2018. 4(1):50-61.
22. Lu, Yao*; Qiu, Ying; Chen, Peng; Chang, Haishuang; Guo, Luqiang; Zhang, Fang; Ma, Li; Zhang, Chi; Zheng, Xin; Xiao, Jun; Zhong, Ruiyue; Han, Lei; Xu, Xiaoyan; Zhang, Yanbo; Li, Dangsheng; Zhong, Guisheng; Boyton, Rosemary; Huang, Ying; He, Yongning; Hu, Ronggui^#; Wei, Bin^#; Wang, Hongyan^#.ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.NATURE MICROBIOLOGY. Dec 2019. 4(12):2331-2346.
23. Zhong, Guisheng*; He, Jiang; Zhou, Ruobo; Damaris Lorenzo; Hazen P Babcock; Vann Bennett; Zhuang, Xiaowei^#.Developmental mechanism of the periodic membrane skeleton in axons.ELIFE. 23 Dec 2014.

专著

专利

项目

奖励

1. 2016 2019，优秀教师

加入我们

课题组成员及合影

姓名：赵思蒙

身份：助理研究员

在组时间：2016/01-至今

邮箱：zhaosm@@shanghaitech.edu.cn
姓名：谈方志

身份：博士后

在组时间：2017/02-至今

邮箱：tanfzh@@shanghaitech.edu.cn
姓名：储岑凤

身份：博士研究生

在组时间：2016/09-至今

邮箱：chucf@@shanghaitech.edu.cn
姓名：陈小玉

身份：博士研究生

在组时间：2014/09-至今

邮箱：chenxy@@shanghaitech.edu.cn
姓名：杨洁

身份：博士研究生

在组时间：2016/09-至今

邮箱：yangjie1@@shanghaitech.edu.cn
姓名：齐洁玉

身份：博士研究生

在组时间：2016/11-至今

邮箱：jieyuq@@seu.edu.cn
姓名：张李燕

身份：博士研究生

在组时间：2019/09-至今

邮箱：230198873@@seu.edu.cn
姓名：王权

身份：硕士研究生

在组时间：2018/09-至今

邮箱：wangquan1@@shanghai.edu.cn
姓名：杨柳

身份：博士研究生

在组时间：2018/09-至今

邮箱：yangliu1@@shanghaitech.edu.cn
姓名：苏冰

身份：硕士研究生

在组时间：2018/09-至今

邮箱：subing@@shanghaitech.edu.cn
姓名：柯君子

身份：硕士研究生

在组时间：2020/11-至今

邮箱：kejz@shanghaitech.edu.cn
姓名：刘潇逸

身份：硕士研究生

在组时间：2019/11-至今

邮箱：liuxy11@shanghaitech.edu.cn
姓名：蓝亿阳

身份：硕士研究生

在组时间：2019/11-至今

邮箱：lanyy@shanghaitechedu.cn
姓名：杨秋香

身份：硕士研究生

在组时间：2019/11-至今

邮箱：yangqx@shanghaitechedu.cn

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