课题组长
姓名:
钟桂生副教授 研究员 博士生导师, PhD, 副教授
职务:
所在院所:
生命科学与技术学院、iHuman研究所
荣誉称号:
教育经历:
-
1995/09—1999/07,安徽大学,学士
-
1999/09—2002/07,中国科学技术大学,硕士
-
2002/09—2007/05,美国康奈尔大学,博士
博士后及工作经历:
- 2007/06—2010/07,美国康奈尔大学,博士后
- 2010/07—2015/01,美国哈佛大学,研究助理
- 2015/01—2020/08,上海科技大学,生命科学与技术学院、iHuman研究所,助理教授(TENURE-TRACK)
- 2017/01—至今,上海科技大学,iHuman研究所,助理所长
- 2020/08—至今,上海科技大学,生命科学与技术学院、iHuman研究所,副教授(TENURED)
课题组简介
研究内容:
本课题组发展和优化新型腺相关病毒(AAV),开发基因治疗在耳聋、视觉遗传性疾病以及神经系统疾病领域的应用。课题组结合病毒改造、分子生物学、单分子成像、超分辨显微成像、电生理等方法具体研究耳蜗的结构和功能。课题组注重和医院合作研究疾病的发病机制及探索可能的治疗手段。
代表性论文(*第一作者,#通讯作者)
- 1. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng#.Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 11 Nov 2020. 11(1).
- 2. Tan, Fangzhi#*; Chu, Cenfeng; Qi, Jieyu; Li, Wenyan; You, Dan; Li, Ke; Chen, Xin; Zhao, Weidong; Cheng, Cheng; Liu, Xiaoyi; Qiao, Yunbo; Su, Bing; He, Shuijin; Zhong, Chao; Li, Huawei#; Chai, Renjie#; Zhong, Guisheng#.AAV-ie enables safe and efficient gene transfer to inner ear cells.NATURE COMMUNICATIONS. 19 Aug 2019. 10.
- 3. Lan, Yiyang*; Tao, Yong; Wang, Yunfeng; Ke, Junzi; Yang, Qiuxiang; Liu, Xiaoyi; Su, Bing; Wu, Yiling; Lin, Chao-Po; Zhong, Guisheng#.Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY. 18 May 2020.
- 4. Qiao, Yunbo#*; Wang, Zejian*; Tan, Fangzhi*; Chen, Jun*; Lin, Jianxiang; Yang, Jie; Li, Hui; Wang, Xiongjun; Sali, Andrej; Zhang, Liye#; Zhong, Guisheng#.Enhancer Reprogramming within Pre-existing Topologically Associated Domains Promotes TGF-beta-Induced EMT and Cancer Metastasis.MOLECULAR THERAPY. 02 Sep 2020. 28(9):2083-2095.
- 5. Liu, Yan*; Qi, Jieyu*; Chen, Xin*; Tang, Mingliang*; Chu, Cenfeng; Zhu, Weijie; Li, Hui; Tian, Cuiping; Yang, Guang; Zhong, Chao; Zhang, Ying; Ni, Guangjian; He, Shuijin#; Chai, Renjie#; Zhong, Guisheng#.Critical role of spectrin in hearing development and deafness.SCIENCE ADVANCES. Apr 2019. 5(4).
- 6. Chen, Xiaoyu*; Xu, Yueming; Qu, Lu; Wu, Lijie; Han, Gye Won; Guo, Yu; Wu, Yiran; Zhou, Qingtong; Sun, Qianqian; Chu, Cenfeng; Yang, Jie; Yang, Liu; Wang, Quan; Yuan, Shuguang; Wang, Ling; Hu, Tao; Tao, Houchao; Sun, Yaping; Song, Yunpeng; Hu, Liaoyuan; Liu, Zhi-Jie; Stevens, Raymond C.; Zhao, Suwen#; Wu, Dong#; Zhong, Guisheng#.Molecular Mechanism for Ligand Recognition and Subtype Selectivity of alpha(2C) Adrenergic Receptor.CELL REPORTS. 03 Dec 2019. 29(10):2936-+.
- 7. Qi, Jieyu*; Liu, Yan; Chu, Cenfeng; Chen, Xin; Zhu, Weijie; Shu, Yilai; He, Shuijin#; Chai, Renjie#; Zhong, Guisheng#.A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.CELL DISCOVERY. 19 Feb 2019. 5.
- 8. Zhang, Bingjie*; Zhao, Simeng; Yang, Dehua; Wu, Yiran; Xin, Ye; Cao, Haijie; Huang, Xi-Ping; Cai, Xiaoqing; Sun, Wen; Ye, Na; Xu, Yueming; Peng, Yao; Zhao, Suwen; Liu, Zhi-Jie; Zhong, Guisheng#; Wang, Ming-Wei#; Shui, Wenqing#.A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts.ACS CENTRAL SCIENCE. 26 Feb 2020. 6(2):213-225.
- 9. Xu, Ke*; Zhong, Guisheng; Zhuang, Xiaowei#.Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons.SCIENCE. 2013. 339(6118):452-456.
- 10. Zhong, Guisheng*; Sharma, Kamal; Harris-Warrick, Ronald M.#.Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.NATURE COMMUNICATIONS. 2011. 2.
- 11. Qu, Lu*; Zhou, Qingtong; Xu, Yueming; Guo, Yu; Chen, Xiaoyu; Yao, Deqiang; Han, Gye Won; Liu, Zhi-Jie; Stevens, Raymond C.; Zhong, Guisheng#; Wu, Dong#; Zhao, Suwen#.Structural Basis of the Diversity of Adrenergic Receptors.CELL REPORTS. 03 Dec 2019. 29(10):2929-+.
- 12. Fan, Ke-qi*; Li, Yi-yuan; Wang, Hao-li; Mao, Xin-tao; Guo, Jin-xin; Wang, Fei; Huang, Ling-jie; Li, Yi-ning; Ma, Xiang-yu; Gao, Zheng-jun; Chen, Wei; Qian, Dan-dan; Xue, Wen-jin; Cao, Qian; Zhang, Lei; Shen, Li; Zhang, Long; Tong, Chao; Zhong, Jiang-yan; Lu, Wei; Lu, Ling; Ren, Ke-ming; Zhong, Guisheng; Wang, Yuan; Tang, Mingliang; Feng, Xin-hua; Chai, Ren-jie#; Jin, Jin#.Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.CELL. 31 Oct 2019. 179(4):864-+.
- 13. Zhao, Yanan*; Wu, Xuanyuan; Chen, Xin; Li, Jianan; Tian, Cuiping; Chen, Jiangrui; Xiao, Cheng; Zhong, Guisheng#; He, Shuijin#.Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury.ISCIENCE. 21 Feb 2020. 23(2).
- 14. Shim, Sang-Hee*; Xia, Chenglong; Zhong, Guisheng; Babcock, Hazen P.; Vaughan, Joshua C.; Huang, Bo; Wang, Xun; Xu, Cheng; Bi, Guo-Qiang#; Zhuang, Xiaowei#.Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(35):13978-13983.
- 15. Zhong, Guisheng*; Shevtsova, Natalia A.; Rybak, Ilya A.; Harris-Warrick, Ronald M.#.Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization.JOURNAL OF PHYSIOLOGY-LONDON. 2012. 590(19):4735-4759.
- 16. Zhong, Guisheng*; Droho, Steven; Crone, Steven A.; Dietz, Shelby; Kwan, Alex C.; Webb, Watt W.; Sharma, Kamal; Harris-Warrick, Ronald M.#.Electrophysiological Characterization of V2a Interneurons and Their Locomotor-Related Activity in the Neonatal Mouse Spinal Cord.JOURNAL OF NEUROSCIENCE. 2010. 30(1):170-182.
- 17. Crone, Steven A.*; Zhong, Guisheng; Harris-Warrick, Ronald#; Sharma, Kamal#.In Mice Lacking V2a Interneurons, Gait Depends on Speed of Locomotion.JOURNAL OF NEUROSCIENCE. 2009. 29(21):7098-7109.
- 18. Yu, Jing*; Liu, Zaizhou; Liang, Yuanyuan; Luo, Feng; Zhang, Jie; Tian, Cuiping; Motzik, Alex; Zheng, Mengmeng; Kang, Jingwu; Zhong, Guisheng; Liu, Cong; Fang, Pengfei; Guo, Min; Razin, Ehud#; Wang, Jing#.Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.NATURE COMMUNICATIONS. 11 Oct 2019. 10.
- 19. Hao, Kaili*; Lei, Wei; Wu, Hongchun; Wu, Jie; Yang, Zhuangzhuang; Yan, Shiping; Lu, Xing-Ai; Li, Jingjing; Xia, Xue; Han, Xinglong; Deng, Wenbo; Zhong, Guisheng; Zhao, Zhen-Ao; Hu, Shijun#.LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.THERANOSTICS. 2019. 9(24):7282-7297.
- 20. An, Bolin*; Wang, Xinyu; Cui, Mengkui; Gui, Xinrui; Mao, Xiuhai; Liu, Yan; Li, Ke; Chu, Cenfeng; Pu, Jiahua; Ren, Susu; Wang, Yanyi; Zhong, Guisheng; Lu, Timothy K.; Liu, Cong; Zhong, Chao#.Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.ACS NANO. Jul 2017. 11(7):6985-6995.
- 21. Peng Yao*; Zhao Simeng; Wu Yiran; Cao Haijie; Xu Yueming; Liu Xiaoyan; Shui Wenqing; Cheng Jianjun; Zhao Suwen; Shen Ling; Ma Jun; Quinn Ronald J; Raymond C. Stevens; Zhong Guisheng; Liu Zhijie.Identification of natural products as novel ligands for the human 5-HT_(2C) receptor.BIOPHYSICS REPORTS. 2018. 4(1):50-61.
- 22. Lu, Yao*; Qiu, Ying; Chen, Peng; Chang, Haishuang; Guo, Luqiang; Zhang, Fang; Ma, Li; Zhang, Chi; Zheng, Xin; Xiao, Jun; Zhong, Ruiyue; Han, Lei; Xu, Xiaoyan; Zhang, Yanbo; Li, Dangsheng; Zhong, Guisheng; Boyton, Rosemary; Huang, Ying; He, Yongning; Hu, Ronggui#; Wei, Bin#; Wang, Hongyan#.ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.NATURE MICROBIOLOGY. Dec 2019. 4(12):2331-2346.
- 23. Zhong, Guisheng*; He, Jiang; Zhou, Ruobo; Damaris Lorenzo; Hazen P Babcock; Vann Bennett; Zhuang, Xiaowei#.Developmental mechanism of the periodic membrane skeleton in axons.ELIFE. 23 Dec 2014.
课题组成员及合影
-
姓名:赵思蒙
身份:助理研究员
在组时间:2016/01-至今
邮箱:zhaosm@@shanghaitech.edu.cn
-
姓名:谈方志
身份:博士后
在组时间:2017/02-至今
邮箱:tanfzh@@shanghaitech.edu.cn
-
姓名:储岑凤
身份:博士研究生
在组时间:2016/09-至今
邮箱:chucf@@shanghaitech.edu.cn
-
姓名:陈小玉
身份:博士研究生
在组时间:2014/09-至今
邮箱:chenxy@@shanghaitech.edu.cn
-
姓名:杨洁
身份:博士研究生
在组时间:2016/09-至今
邮箱:yangjie1@@shanghaitech.edu.cn
-
姓名:齐洁玉
身份:博士研究生
在组时间:2016/11-至今
邮箱:jieyuq@@seu.edu.cn
-
姓名:张李燕
身份:博士研究生
在组时间:2019/09-至今
邮箱:230198873@@seu.edu.cn
-
姓名:王权
身份:硕士研究生
在组时间:2018/09-至今
邮箱:wangquan1@@shanghai.edu.cn
-
姓名:杨柳
身份:博士研究生
在组时间:2018/09-至今
邮箱:yangliu1@@shanghaitech.edu.cn
-
姓名:苏冰
身份:硕士研究生
在组时间:2018/09-至今
邮箱:subing@@shanghaitech.edu.cn
-
姓名:柯君子
身份:硕士研究生
在组时间:2020/11-至今
邮箱:kejz@shanghaitech.edu.cn
-
姓名:刘潇逸
身份:硕士研究生
在组时间:2019/11-至今
邮箱:liuxy11@shanghaitech.edu.cn
-
姓名:蓝亿阳
身份:硕士研究生
在组时间:2019/11-至今
邮箱:lanyy@shanghaitechedu.cn
-
姓名:杨秋香
身份:硕士研究生
在组时间:2019/11-至今
邮箱:yangqx@shanghaitechedu.cn
|