Principal investigator
Name:
Guisheng ZhongAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology/ iHuman Institute
Honor:
Education Background:
- 1995/09-1999/07, Anhui University, Bachelor
- 1999/09-2002/07, University of Science and Technology of China, Master
- 2002/09-2007/05, Cornell University, USA, Doctor
Working Experience:
- 2007/06-2010/07, Cornell University, USA, Postdoctoral
- 2010/07-2015/01, Harvard University, USA, Research assistant
- 2015/01-2020/08, ShanghaiTech University, PI, Associate Professor(tenure-track)
- 2020/08-now, ShanghaiTech University, PI, Associate Professor(tenured)
- 2017/01-now, iHuman Institute, ShanghaiTech University, Assistant Director
Group Introduction
Research Area:
Neurobiology, Superresolution Optics
Research Interests:
Dr. Zhong's group is studing gene therapy by using adeno-associated virus (AAV). Dr. Zhong's group focuses on the development of new AAVs in auditory, ophthalmology and central nervous system to develop gene therapy applications in more fields.They combined virus modification, molecular biology, single-molecule imaging, super-resolution microscopy, electrophysiology and other methods to study the structure and function of the cochlea cells. They focus on cooperating with hospitals to study the pathogenesis of diseases and explore potential treatments.
Representative Publications (*First Author, # Corresponding Author)
- 1. Simeng Zhao*#; Qiuxiang Yang*; Zehua Yu*; Cenfeng Chu; Shengqi Dai; Hongli Li; Min Diao; Lingyue Feng; Junzi Ke; Yilin Xue; Qifang Zhou; Yan Liu; Hanhui Ma; Chao-Po Lin; Yong-Gang Yao; Guisheng Zhong#.Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness.NEURON. 21 Apr 2025. 113(10).
- 2. Cai, Yuan*#; Gu, Yonghao#; Zhang, Jie; Zhu, Ying; Ma, Zhen; He, Qin; Sun, Yongjia; Yuan, Mengmeng; Li, Xiaojun; Zhu, Kai; Miao, Bolong; Zhao, Jin; Liu, Juan; Tang, Min; Tong, Dali; Feng, Lixia; Ma, Ming#; Zhong, Guisheng#; Qiu, Zilong#; Xue, Tian#.An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients.RESEARCH. 29 May 2025. 8.
- 3. Gong, Yajun*; Huang, Xianyu; Tu, Tianxiang; Chu, Cenfeng; Xian, Chunrui; Yuan, Yushun; Fu, Xin; Li, Ruobi; Zhong, Guisheng#; Zhou, Xiaolai#.A novel AAV Vector for gene therapy of RPE-related retinal degenerative diseases via intravitreal delivery.MOLECULAR NEURODEGENERATION. 25 Nov 2024. 19(1).
- 4. Qi, Jieyu*#; Tan, Fangzhi#; Zhang, Liyan; Zhou, Yinyi; Zhang, Ziyu; Sun, Qiuhan; Li, Nianci; Fang, Yuan; Chen, Xin; Wu, Yunhao; Zhong, Guisheng#; Chai, Renjie#.Critical role of TPRN rings in the stereocilia for hearing.MOLECULAR THERAPY. 03 Jan 2024. 32(1):204-217.
- 5. Zhao, Simeng*; Ke, Junzi; Yang, Boyu; Tan, Fangzhi; Yang, Jie; Lin, Chao Po; Wang, Haopeng#; Zhong, Guisheng#.A protective AAV vaccine for SARS-CoV-2.SIGNAL TRANSDUCTION AND TARGETED THERAPY. 05 Sep 2022. 7(1).
- 6. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng#.Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 2020. 11(1):5699.
- 7. Tan, Fangzhi*#; Chu, Cenfeng*; Qi, Jieyu*; Li, Wenyan*; You, Dan; Li, Ke; Chen, Xin; Zhao, Weidong; Cheng, Cheng; Liu, Xiaoyi; Qiao, Yunbo; Su, Bing; He, Shuijin; Zhong, Chao; Li, Huawei#; Chai, Renjie#; Zhong, Guisheng#.AAV-ie enables safe and efficient gene transfer to inner ear cells.NATURE COMMUNICATIONS. 19 Aug 2019. 10.
- 8. Liu, Yan*; Qi, Jieyu*; Chen, Xin*; Tang, Mingliang*; Chu, Cenfeng; Zhu, Weijie; Li, Hui; Tian, Cuiping; Yang, Guang; Zhong, Chao; Zhang, Ying; Ni, Guangjian; He, Shuijin#; Chai, Renjie#; Zhong, Guisheng#.Critical role of spectrin in hearing development and deafness.SCIENCE ADVANCES. Apr 2019. 5(4).
- 9. Tao, Yong*; Liu, Xiaoyi; Yang, Liu; Chu, Cenfeng; Tan, Fangzhi; Yu, Zehua; Ke, Junzi; Li, Xiang; Zheng, Xiaofei; Zhao, Xingle; Qi, Jieyu; Lin, Chao Po; Chai, Renjie#; Zhong, Guisheng#; Wu, Hao#.AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration.SIGNAL TRANSDUCTION AND TARGETED THERAPY. 22 Apr 2022. 7(1).
- 10. Lan, Yiyang*; Tao, Yong; Wang, Yunfeng; Ke, Junzi; Yang, Qiuxiang; Liu, Xiaoyi; Su, Bing; Wu, Yiling; Lin, Chao-Po; Zhong, Guisheng#.Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY. Aug 2020.
- 11. Li, Shanshan*; Luo, Huoqing; Lou, Ronghui; Tian, Cuiping; Miao, Chen; Xia, Lisha; Pan, Chen; Duan, Xiaoxiao; Dang, Ting; Li, Hui; Fan, Chengyu; Tang, Pan; Zhang, Zhuangzhuang; Liu, Yan; Li, Yunxia; Xu, Fei; Zhang, Yaoyang; Zhong, Guisheng#; Hu, Ji#; Shui, Wenqing#.Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression.SCIENCE ADVANCES. 2021. 7(30):eabf0634.
- 12. Qiao, Yunbo*#; Wang, Zejian*; Tan, Fangzhi*; Chen, Jun*; Lin, Jianxiang; Yang, Jie; Li, Hui; Wang, Xiongjun; Sali, Andrej; Zhang, Liye#; Zhong, Guisheng#.Enhancer Reprogramming within Pre-existing Topologically Associated Domains Promotes TGF-beta-Induced EMT and Cancer Metastasis.MOLECULAR THERAPY. 02 Sep 2020. 28(9):2083-2095.
- 13. Zhang, Bingjie*; Zhao, Simeng; Yang, Dehua; Wu, Yiran; Xin, Ye; Cao, Haijie; Huang, Xi-Ping; Cai, Xiaoqing; Sun, Wen; Ye, Na; Xu, Yueming; Peng, Yao; Zhao, Suwen; Liu, Zhi-Jie; Zhong, Guisheng#; Wang, Ming-Wei#; Shui, Wenqing#.A novel G protein-biased and subtype-selective agonist for a G protein-coupled receptor discovered from screening herbal extracts.ACS CENTRAL SCIENCE. 2020. 6(2):213-225.
- 14. Chen, Xiaoyu*; Xu, Yueming; Qu, Lu; Wu, Lijie; Han, Gye Won; Guo, Yu; Wu, Yiran; Zhou, Qingtong; Sun, Qianqian; Chu, Cenfeng; Yang, Jie; Yang, Liu; Wang, Quan; Yuan, Shuguang; Wang, Ling; Hu, Tao; Tao, Houchao; Sun, Yaping; Song, Yunpeng; Hu, Liaoyuan; Liu, Zhi-Jie; Stevens, Raymond C.; Zhao, Suwen#; Wu, Dong#; Zhong, Guisheng#.Molecular Mechanism for Ligand Recognition and Subtype Selectivity of alpha(2C) Adrenergic Receptor.CELL REPORTS. 03 Dec 2019. 29(10):2936-+.
- 15. Qi, Jieyu*; Liu, Yan*; Chu, Cenfeng; Chen, Xin; Zhu, Weijie; Shu, Yilai; He, Shuijin#; Chai, Renjie#; Zhong, Guisheng#.A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.CELL DISCOVERY. 19 Feb 2019. 5.
- 16. Xu, Ke*; Zhong, Guisheng; Zhuang, Xiaowei#.Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons.SCIENCE. 2013. 339(6118):452-456.
- 17. Zhong, Guisheng*; Sharma, Kamal; Harris-Warrick, Ronald M.#.Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.NATURE COMMUNICATIONS. 2011. 2.
- 18. Qu, Lu*; Zhou, Qingtong; Xu, Yueming; Guo, Yu; Chen, Xiaoyu; Yao, Deqiang; Han, Gye Won; Liu, Zhi-Jie; Stevens, Raymond C.; Zhong, Guisheng#; Wu, Dong#; Zhao, Suwen#.Structural Basis of the Diversity of Adrenergic Receptors.CELL REPORTS. 03 Dec 2019. 29(10):2929-+.
- 19. Zhao, Simeng*; Liu, Fengjiang; Qiu, Shizhen; Lan, Qiaoshuai; Wu, Yiran; Xu, Wei; Ke, Junzi; Yang, Jie; Liu, Xiaoyan; Wang, Kun; Guo, Hangtian; Xia, Shuai; Zhang, Fangfang; Wang, Jiabei; Hu, Xiaowen; Lu, Lu; Jiang, Shibo; Zhao, Suwen; Liu, Lianxin#; Xie, Youhua#; Yang, Xiuna#; Wang, Haopeng#; Zhong, Guisheng#.A core epitope targeting antibody of SARS-CoV-2.PROTEIN & CELL. 20 Jan 2023. 14(1).
- 20. Chu, Cenfeng*; Zhang, Huifang; Jia, Guodong; Zhong, Guisheng.Developing Novel AAV Capsids for Ophthalmic Gene Therapy.MOLECULAR THERAPY. 01 May 2023. 31(4).
- 21. Fan, Ke-qi*; Li, Yi-yuan; Wang, Hao-li; Mao, Xin-tao; Guo, Jin-xin; Wang, Fei; Huang, Ling-jie; Li, Yi-ning; Ma, Xiang-yu; Gao, Zheng-jun; Chen, Wei; Qian, Dan-dan; Xue, Wen-jin; Cao, Qian; Zhang, Lei; Shen, Li; Zhang, Long; Tong, Chao; Zhong, Jiang-yan; Lu, Wei; Lu, Ling; Ren, Ke-ming; Zhong, Guisheng; Wang, Yuan; Tang, Mingliang; Feng, Xin-hua; Chai, Ren-jie#; Jin, Jin#.Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.CELL. 31 Oct 2019. 179(4):864-+.
- 22. Zhao, Yanan*; Wu, Xuanyuan*; Chen, Xin; Li, Jianan; Tian, Cuiping; Chen, Jiangrui; Xiao, Cheng; Zhong, Guisheng#; He, Shuijin#.Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury.ISCIENCE. 21 Feb 2020. 23(2).
- 23. Shim, Sang-Hee*; Xia, Chenglong; Zhong, Guisheng; Babcock, Hazen P.; Vaughan, Joshua C.; Huang, Bo; Wang, Xun; Xu, Cheng; Bi, Guo-Qiang#; Zhuang, Xiaowei#.Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(35):13978-13983.
- 24. Zhong, Guisheng*; Shevtsova, Natalia A.; Rybak, Ilya A.; Harris-Warrick, Ronald M.#.Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization.JOURNAL OF PHYSIOLOGY-LONDON. 2012. 590(19):4735-4759.
- 25. Zhong, Guisheng*; Droho, Steven; Crone, Steven A.; Dietz, Shelby; Kwan, Alex C.; Webb, Watt W.; Sharma, Kamal; Harris-Warrick, Ronald M.#.Electrophysiological Characterization of V2a Interneurons and Their Locomotor-Related Activity in the Neonatal Mouse Spinal Cord.JOURNAL OF NEUROSCIENCE. 2010. 30(1):170-182.
- 26. Crone, Steven A.*; Zhong, Guisheng; Harris-Warrick, Ronald#; Sharma, Kamal#.In Mice Lacking V2a Interneurons, Gait Depends on Speed of Locomotion.JOURNAL OF NEUROSCIENCE. 2009. 29(21):7098-7109.
- 27. Yu, Jing*; Liu, Zaizhou; Liang, Yuanyuan; Luo, Feng; Zhang, Jie; Tian, Cuiping; Motzik, Alex; Zheng, Mengmeng; Kang, Jingwu; Zhong, Guisheng; Liu, Cong; Fang, Pengfei; Guo, Min; Razin, Ehud#; Wang, Jing#.Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.NATURE COMMUNICATIONS. 11 Oct 2019. 10.
- 28. Hao, Kaili*; Lei, Wei; Wu, Hongchun; Wu, Jie; Yang, Zhuangzhuang; Yan, Shiping; Lu, Xing-Ai; Li, Jingjing; Xia, Xue; Han, Xinglong; Deng, Wenbo; Zhong, Guisheng; Zhao, Zhen-Ao; Hu, Shijun#.LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.THERANOSTICS. 2019. 9(24):7282-7297.
- 29. An, Bolin*; Wang, Xinyu*; Cui, Mengkui; Gui, Xinrui; Mao, Xiuhai; Liu, Yan; Li, Ke; Chu, Cenfeng; Pu, Jiahua; Ren, Susu; Wang, Yanyi; Zhong, Guisheng; Lu, Timothy K.; Liu, Cong; Zhong, Chao#.Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.ACS NANO. Jul 2017. 11(7):6985-6995.
- 30. Peng Yao*; Zhao Simeng; Wu Yiran; Cao Haijie; Xu Yueming; Liu Xiaoyan; Shui Wenqing; Cheng Jianjun; Zhao Suwen; Shen Ling; Ma Jun; Quinn Ronald J; Raymond C. Stevens; Zhong Guisheng#; Liu Zhijie#.Identification of natural products as novel ligands for the human 5-HT_(2C) receptor.BIOPHYSICSREPORTS. 2018. 4(1):50-61.
- 31. Lu, Yao*; Qiu, Ying; Chen, Peng; Chang, Haishuang; Guo, Luqiang; Zhang, Fang; Ma, Li; Zhang, Chi; Zheng, Xin; Xiao, Jun; Zhong, Ruiyue; Han, Lei; Xu, Xiaoyan; Zhang, Yanbo; Li, Dangsheng; Zhong, Guisheng; Boyton, Rosemary; Huang, Ying; He, Yongning; Hu, Ronggui#; Wei, Bin#; Wang, Hongyan#.ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.NATURE MICROBIOLOGY. Dec 2019. 4(12):2331-2346.
- 32. Zhong, Guisheng*; He, Jiang; Zhou, Ruobo; Damaris Lorenzo; Hazen P Babcock; Vann Bennett; Zhuang, Xiaowei#.Developmental mechanism of the periodic membrane skeleton in axons.ELIFE. 23 Dec 2014.
Awards
- 1. 2016, Outstanding Teacher
- 2. 2019, Outstanding Teacher
Group Member and Photo
-
Name:Zhao Simeng
Position:Research Assistant Professor
Duration:2016/01-now
Email:zhaosm@@shanghaitech.edu.cn
-
Name:Chu Cenfeng
Position:Doctoral Student
Duration:2016/09-2021/6
Email:chucf@@shanghaitech.edu.cn
-
Name:Chen Xiaoyu
Position:Doctoral Student
Duration:2014/09-2020/6
Email:chenxy@@shanghaitech.edu.cn
-
Name:Yang Jie
Position:Doctoral Student
Duration:2016/09-2021/6
Email:yangjie1@@shanghaitech.edu.cn
-
Name:Wang Quan
Position:Postgraduate Student
Duration:2018/09-2020/6
Email:wangquan1@@shanghai.edu.cn
-
Name:Yang Liu
Position:Doctoral Student
Duration:2018/09-now
Email:yangliu1@@shanghaitech.edu.cn
-
Name:Su Bing
Position:Doctoral Student
Duration:2018/09-now
Email:subing@@shanghaitech.edu.cn
-
Name:Ke Junzi
Position:Doctoral Student
Duration:2020/11-now
Email:kejz@shanghaitech.edu.cn
-
Name:Liu Xiaoyi
Position:Postgraduate Student
Duration:2019/11-2022/6
Email:liuxy11@shanghaitech.edu.cn
-
Name:Lan Yiyang
Position:Postgraduate Student
Duration:2019/11-2022/6
Email:lanyy@shanghaitechedu.cn
-
Name:Yang Qiuxiang
Position:Doctoral Student
Duration:2019/11-now
Email:yangqx@shanghaitechedu.cn
-
Name:Yang Boyu
Position:Postgraduate Student
Duration:2021/9-now
Email: yangby1@shanghaitech.edu.cn
-
Name:Yu Zehua
Position:Doctoral Student
Duration:2020/12-now
Email:yuzh1@shanghaitech.edu.cn
-
Name:Zhang Fan
Position:Postdoct
Duration:2021/4-now
Email:zhangfan10@shanghaitech.edu.cn
-
Name:Wang Yunqing
Position:Postgraduate Student
Duration:2021/9-now
Email:wangyq5@shanghaitech.edu.cn
-
Name:Yang Shenghui
Position:Postgraduate Student
Duration:2021/9-now
Email:yangshh@shanghaitech.edu.cn
-
Name:Xian Chunrui
Position:Postgraduate Student
Duration:2021/1-now
Email:xianchr@shanghaitech.edu.cn
-
Name:Zhao Xinying
Position:Postgraduate Student
Duration:2022/7-now
Email:zhaoxy3@shanghaitech.edu.cn


|