中文信息

心血管发育与疾病研究组

课题组长

姓名：

张辉副教授研究员博士生导师, PhD, 副教授

职务：

所在院所：

生命科学与技术学院

荣誉称号：

教育经历：

2004/09—2008/06，华中农业大学，学士
2008/09—2014/03，中国科学院上海生命科学研究院，博士

博士后及工作经历：

2014/04—2016/03，中国科学院上海生命科学研究院，博士后
2016/04—2016/10，中国科学院上海生命科学研究院，副研究员
2016/11—2022/09，上海科技大学，生命科学与技术学院，助理教授（TENURE-TRACK）
2022/09—至今，上海科技大学，生命科学与技术学院，副教授（TENURED）

课题组简介

研究方向：

细胞谱系示踪；心血管发育；心脏再生与修复

研究内容：

利用遗传谱系示踪技术研究胚胎发育过程中的细胞命运变化，解析心血管系统及其它组织器官的发育过程及其调控机理；研究心脏受损后发生心脏重构（如纤维化、炎细胞浸润、血管新生等）的细胞分子机制，研发促进心脏再生修复的新策略。

课题组网站：

研究成果展示

1. 心血管发育及内皮细胞命运可塑性

(1) 系统综述了心脏发育过程中以及病理状态下心内膜细胞的多能性（Zhang et al, Circulation Research 2018）

(2) 胚胎发育过程中心内膜细胞向成纤维细胞、平滑肌细胞、周细胞和脂肪细胞分化的转变过程（Huang et al, JBC 2019）

(3) 胚胎内血管内皮细胞的起源之谜（Feng et al, Circulation Research 2020）

(4) 心梗后，将心内膜细胞命运重塑为冠状血管内皮细胞可以减少心脏纤维化、改善心功能（Jiang et al, Cell Research 2020）

2. 心脏再生修复的细胞分子机制

(1) 新生心脏再生过程中细胞衰老的发生机制以及细胞衰老对心脏再生的促进作用（Feng et al, Circulation 2019）

(2) 研发出具有药物缓释功能的新型蛋白质水凝胶，可作为载药心脏补片促进心脏再生（Jiang et al, Advanced Materials 2022）

3. 脂肪相关心脏疾病与心脏脂肪起源

(1) 心脏发育及稳态条件下心脏脂肪的起源（Jiang et al, Cell Rep 2021）

(2) 心脏脂肪的起源及功能（Lu et al, FEBS J 2022）

(3) 致心律失常性心肌病中脂肪的起源（Huang et al, Science China Life Sciences 2023）

代表性论文（*第一作者，#通讯作者）

1. Huang, Xinyan*; Yan, Lei; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan^#; Zhu, Ping^#; Zhang, Hui^#.Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
2. Jiang, Xiaoyu*; Feng, Teng; An, Bolin; Ren, Susu; Meng, Jufeng; Li, Ke; Liu, Suying; Wu, Haiying; Zhang, Hui^#; Zhong, Chao^#.A Bi-layer Hydrogel Cardiac Patch Made of Recombinant Functional Proteins.ADVANCED MATERIALS. May 2022. 34:e2201411.
3. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan^#; Lin, Chao-Po^#; Zhang, Hui^#.Functions and origins of cardiac fat.FEBS JOURNAL. 2022. Published online.
4. Huang, Xinyan*; Yan, Lei*; Kou, Shan; Meng, Jufeng; Lu, Zhengkai; Lin, Chao-Po; Liu, Chen^#; Zhang, Hui^#.Generation and characterization of a Myh6-driven Cre knockin mouse line.TRANSGENIC RESEARCH. Dec 2021. 30(6):821-835.
5. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen^#; Zhang, Hui^#.PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 02 Feb 2021. 34(5):108697.
6. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui^#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. Apr 2021. 31:485-487.
7. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui^#.No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs.CIRCULATION RESEARCH. 23 Oct 2020. 127(10):1221-1232.
8. Feng, Teng*; Meng, Jufeng; Kou, Shan; Jiang, Zhen; Huang, Xinyan; Lu, Zhengkai; Zhao, Huan; Lau, Lester F.; Zhou, Bin^#; Zhang, Hui^#.CCN1-Induced Cellular Senescence Promotes Heart Regeneration.CIRCULATION. 2019. 139(21):2495-2498.
9. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui^#.Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
10. Zhang, Hui^#*; Lui, Kathy O.^#; Zhou, Bin^#.Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
11. Zhang, Hui^#*; Huang, Xiuzhen*; Liu, Kuo*; Tang, Juan*; He, Lingjuan; Pu, Wenjuan; Liu, Qiaozhen; Li, Yan; Tian, Xueying; Wang, Yue; Zhang, Libo; Yu, Ying; Wang, Hongyan; Hu, Ronggui; Wang, Fengchao; Chen, Ting; Wang, Qing-Dong; Qiao, Zengyong; Zhang, Li; Lui, Kathy O.; Zhou, Bin^#.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
12. Zhang, Hui*; Pu, Wenjuan; Li, Guang; Huang, Xiuzhen; He, Lingjuan; Tian, Xueying; Liu, Qiaozhen; Zhang, Libo; Wu, Sean M.; Sucov, Henry M.; Zhou, Bin^#.Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
13. Zhang, Hui*; Pu, Wenjuan; Tian, Xueying; Huang, Xiuzhen; He, Lingjuan; Liu, Qiaozhen; Li, Yan; Zhang, Libo; He, Liang; Liu, Kuo; Gillich, Astrid; Zhou, Bin^#.Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
14. Zhang, Hui*; Pu, Wenjuan; Liu, Qiaozhen; He, Lingjuan; Huang, Xiuzhen; Tian, Xueying; Zhang, Libo; Nie, Yu; Hu, Shengshou; Lui, Kathy O.; Zhou, Bin^#.Endocardium Contributes to Cardiac Fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
15. Zhang, Hui*; Von Gise, Alexander; Liu, Qiaozhen; Hu, Tianyuan; Tian, Xueying; He, Lingjuan; Pu, Wenjuan; Huang, Xiuzhen; He, Liang; Cai, Chen-Leng; Camargo, Fernando D.; Pu, William T.; Zhou, Bin^#.Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion.JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289(27):18681-18692.
16. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan*; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhen; Yan, Yan; Yang, Xiao; Zhong, Tao P.; Pu, William T.; Zhou, Bin^#.De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
17. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin^#.Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.