张辉, PhD副教授研究员博士生导师

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邮箱： zhanghui1@@shanghaitech.edu.cn

传真： 86-21-20685430

地址：上海市浦东新区华夏中路393号

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中文信息English

心血管发育与再生研究组

课题组长

姓名：

张辉副教授研究员博士生导师, PhD, 副教授

职务：

所在院所：

生命科学与技术学院

荣誉称号：

教育经历：

2004/09—2008/06，华中农业大学，学士
2008/09—2014/03，中国科学院上海生命科学研究院，博士

博士后及工作经历：

2014/04—2016/03，中国科学院上海生命科学研究院，博士后
2016/04—2016/10，中国科学院上海生命科学研究院，副研究员
2016/11—2022/09，上海科技大学，生命科学与技术学院，助理教授（TENURE-TRACK）
2022/09—至今，上海科技大学，生命科学与技术学院，副教授（TENURED）

课题组简介

研究方向：

心血管发育；心脏再生修复；细胞命运示踪

研究内容：

（1）利用单细胞测序、遗传谱系示踪、多组学技术以及基因操纵表达等方法研究心血管系统在发育、生长和老化过程中的细胞命运变化，包括细胞分化、增殖、迁移和衰老等，并探讨其调控机制。

（2）研究心脏损伤后的重塑机制，开发促进心肌细胞增殖、降低心脏纤维化和刺激心脏血管新生的有效策略，为心肌梗死和心力衰竭等心脏相关疾病的治疗提供理论基础。

课题组网站：

研究成果展示

一、心肌再生

1.发现新生心脏再生过程中存在成纤维细胞衰老现象并揭示细胞衰老对心脏再生的调控作用和机制（Feng et al, Circulation 2019）

2.利用新型心脏补片作为药物载体揭示分泌型蛋白FSTL1对成体心肌再生的调控作用（Jiang et al, Advanced Materials 2022）

二、心脏纤维化与靶向干预

1.发现新生心脏再生过程中存在成纤维细胞向上皮细胞转换的现象（Gao et al, Stem Cell Research & Therapy 2023）

2.建立靶向FAP+肌成纤维细胞的CAR巨噬细胞策略并用于降低肥大型心衰模型中的纤维化（Gao et al, Cell Discovery 2024）

3.发现在心脏缺血性损伤后，成纤维细胞中印迹基因Pw1会发生母本印迹丢失，上调的PW1通过控制嘌呤从头合成促进细胞外基质的产生，进而增强心脏纤维化（Kou et al, Circulation 2025）

三、内皮重塑与血管新生

1.综述了心脏发育过程中以及病理状态下心脏内膜细胞的多能性（Zhang et al, Circulation Research 2018）

2.利用精准谱系示踪技术阐明胚胎心脏内膜向成纤维细胞、血管壁细胞、脂肪细胞的分化途径（Huang et al, J Biol Chem 2019）

3.利用多种细胞谱系示踪工具揭示胚胎血管内皮起源（Feng et al, Circulation Research 2020）

4.发现诱导成体心脏内膜细胞转分化为冠状血管内皮细胞可促进心梗损伤后的心脏修复（Jiang et al, Cell Research 2021）

5.发现心脏血管周细胞增殖能力不足是导致心梗后血管再生的“限速酶”，靶向周细胞或成治疗新策略（Lu et al, iScience 2025）

四、脂肪细胞起源及功能

1.利用多种细胞谱系示踪工具系统阐明心脏发育及成体稳态条件下心脏脂肪的起源（Jiang et al, Cell Reports 2021）

2.综述了心脏脂肪的起源及功能（Lu et al, FEBS J 2023）

3.利用谱系示踪技术阐明致心律失常性心肌病模型中心脏脂肪起源及其调控机制（Huang et al, Science China Life Sciences 2023）

代表性论文（*第一作者，#通讯作者）

1. Lu, Zhengkai*; Zhou, Jian*; Ye, Min; Meng, Jufeng; Feng, Teng; Jiang, Zhen; Dai, Wenxuan; Deng, Defang; Wei, Yuanxin; Zhang, Wen; Zheng, Jialei; Fu, Yutao; Lin, Chao-Po; Chen, Huiwen; Shi, Guocheng^#; Zhang, Hui^#; Tang, Juan^#.Cardiac mural cells are rate-limiting for coronary vascularization after heart injury.iScience. 2025. In press.
2. Kou, Shan*; Lu, Zhengkai*; Deng, Defang*; Ye, Min; Sui, Yu; Qin, Lieyang; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Lin, Chao-Po; Li, Xiajun; Liu, Chen^#; Tang, Juan^#; Zhang, Hui^#.Activation of imprinted gene PW1 promotes cardiac fibrosis after ischemic injury.CIRCULATION. 2025. 151(9):623-639.
3. Gao, Zibei*; Yan, Lei*; Meng, Jufeng*; Lu, Zhengkai; Ge, Kaixin; Jiang, Zhen; Feng, Teng; Wang, Haopeng; Liu, Chen^#; Tang, Juan^#; Zhang, Hui^#.Targeting cardiac fibrosis with chimeric antigen receptor macrophages.CELL DISCOVERY. 2024. 10 (86).
4. Gao, Zibei*; Lu, Zhengkai*; Meng, Jinyan; Lin, Chao-Po; Zhang, Hui^#; Tang, Juan^#.Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.STEM CELL RESEARCH & THERAPY. 2023. 14(161).
5. Huang, Xinyan*; Yan, Lei*; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan^#; Zhu, Ping^#; Zhang, Hui^#.Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
6. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan^#; Lin, Chao-Po^#; Zhang, Hui^#.Functions and origins of cardiac fat.FEBS JOURNAL. 2023. 290(7):1705-1718.
7. Jiang, Xiaoyu*; Feng, Teng*; An, Bolin; Ren, Susu; Meng, Jufeng; Li, Ke; Liu, Suying; Wu, Haiying; Zhang, Hui^#; Zhong, Chao^#.A bi-layer hydrogel cardiac patch made of recombinant functional proteins.ADVANCED MATERIALS. 2022. 34:e2201411.
8. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui^#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
9. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen^#; Zhang, Hui^#.PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 2021. 34(5):108697.
10. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui^#.No evidence for erythro-myeloid progenitor-derived vascular endothelial cells in multiple organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
11. Feng, Teng*; Meng, Jufeng; Kou, Shan; Jiang, Zhen; Huang, Xinyan; Lu, Zhengkai; Zhao, Huan; Lau, Lester F.; Zhou, Bin^#; Zhang, Hui^#.CCN1-induced cellular senescence promotes heart regeneration.CIRCULATION. 2019. 139(21):2495-2498.
12. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui^#.Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
13. Zhang, Hui*^#; Lui, Kathy O.^#; Zhou, Bin^#.Endocardial cell plasticity in cardiac development, diseases and regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
14. Zhang, Hui*; Huang, Xiuzhen*; Liu, Kuo*; Tang, Juan*; He, Lingjuan; Pu, Wenjuan; Liu, Qiaozhen; Li, Yan; Tian, Xueying; Wang, Yue; Zhang, Libo; Yu, Ying; Wang, Hongyan; Hu, Ronggui; Wang, Fengchao; Chen, Ting; Wang, Qing-Dong; Qiao, Zengyong; Zhang, Li; Lui, Kathy O.; Zhou, Bin^#.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
15. Zhang, Hui*; Pu, Wenjuan; Tian, Xueying; Huang, Xiuzhen; He, Lingjuan; Liu, Qiaozhen; Li, Yan; Zhang, Libo; He, Liang; Liu, Kuo; Gillich, Astrid; Zhou, Bin^#.Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
16. Zhang, Hui*; Pu, Wenjuan; Li, Guang; Huang, Xiuzhen; He, Lingjuan; Tian, Xueying; Liu, Qiaozhen; Zhang, Libo; Wu, Sean M.; Sucov, Henry M.; Zhou, Bin^#.Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
17. Zhang, Hui*; Pu, Wenjuan; Liu, Qiaozhen; He, Lingjuan; Huang, Xiuzhen; Tian, Xueying; Zhang, Libo; Nie, Yu; Hu, Shengshou; Lui, Kathy O.; Zhou, Bin^#.Endocardium contributes to cardiac fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
18. Zhang, Hui*; Von Gise, Alexander; Liu, Qiaozhen; Hu, Tianyuan; Tian, Xueying; He, Lingjuan; Pu, Wenjuan; Huang, Xiuzhen; He, Liang; Cai, Chen-Leng; Camargo, Fernando D.; Pu, William T.; Zhou, Bin^#.Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion.JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289(27):18681-18692.
19. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan*; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhen; Yan, Yan; Yang, Xiao; Zhong, Tao P.; Pu, William T.; Zhou, Bin^#.De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
20. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin^#.Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.