英文信息

Principal investigator

Name:

Hui ZhengAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:

Working Experience:

Group Introduction

Research Area:

Epigenetic reprogramming and transgenerational inheritance

Research Interests:

Our lab is interested in understanding the dynamic regulation of epigenome in animal gametes development, early embryonic development, cell differentiation, and related human diseases. By taking advantage of cutting-edge methods in molecular biology, genomics, developmental biology, bioinformatics, and also combining “wet” lab and “dry” lab, we aim to investigate key biological questions in the following areas: (1) epigenetic regulation and the underlying mechanism during animal gametogenesis; (2) improvement of epigenome editing technologies; (3) molecular mechanism of mammalian transgenerational epigenetic inheritance.

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Zhang, Ke*; Wu, Dan-Ya*; Zheng, Hui*; Wang, Yao*; Sun, Qiao-Ran; Liu, Xin; Wang, Li-Yan; Xiong, Wen-Jing; Wang, Qiujun; Rhodes, James D.P.; Xu, Kai; Li, Lijia; Lin, Zili; Yu, Guang; Xia, Weikun; Huang, Bo; Du, Zhenhai; Yao, Yao; Nasmyth, Kim A.; Klose, Robert J.; Miao, Yi-Liang^#; Xie, Wei^#.Analysis of genome architecture during SCNT reveals a role of cohesin in impeding minor ZGA..MOLECULAR CELL. Jul 2020.
2. Du, Zhenhai*; Zheng, Hui*; Kawamura, Yumiko K.*; Zhang, Ke*; Gassler, Johanna; Powell, Sean; Xu, Qianhua; Lin, Zili; Xu, Kai; Zhou, Qian; Ozonov, Evgeniy A.; Ve ́ ron, Nathalie; Huang, Bo; Li, Lijia; Yu, Guang; Liu, Ling; Yeung, Wan Kin Au; Wang, Peizhe; Chang, Lei; Wang, Qiujun; He, Aibin; Sun, Yujie; Na, Jie; Sun, Qingyuan; Sasaki, Hiroyuki; Tachibana, Kikue; Peters, Antoine H.F.M.^#; Xie, Wei^#.Polycomb group proteins regulate chromatin architecture in mouse oocytes and early embryos..MOLECULAR CELL. Feb 2020.
3. Zheng, Hui*; Xie, Wei^#.The role of 3D genome organization in development and cell differentiation..NATURE REVIEWS MOLECULAR CELL BIOLOGY. Sep 2019.
4. Li, Yuanyuan*; Zheng, Hui*; Wang, Qiujun; Zhou, Chen; Wei, Lei; Liu, Xuehui; Zhang, Wenhao; Zhang, Yu; Du, Zhenhai; Wang, Xiaowo; Xie, Wei^#.Genomewide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valley..GENOME BIOLOGY. Feb 2018.
5. Du, Zhenhai*; Zheng, Hui; Huang, Bo; Ma, Rui; Wu, Jingyi; Zhang, Xianglin; He, Jing; Xiang, Yunlong; Wang, Qiujun; Li, Yuanyuan; Ma, Jing; Zhang, Xu; Zhang, Ke; Wang, Yang; Zhang, Michael Q; Gao, Juntao; Dixon, Jesse R; Wang, Xiaowo; Zeng, Jianyang; Xie, Wei^#.Allelic reprogramming of 3D chromatin architecture during early mammalian development..NATURE. Jul 2017.
6. Zhang, Bingjie*; Zheng, Hui*; Huang, Bo*; Li, Wenzhi*; Xiang, Yunlong; Peng, Xu; Ming, Jia; Wu, Xiaotong; Zhang, Yu; Xu, Qianhua; Liu, Wenqiang; Kou, Xiaochen; Zhao, Yanhong; He, Wenteng; Li, Chong; Chen, Bo; Li, Yuanyuan; Wang, Qiujun; Ma, jing; Yin, Qiangzong; Kee, Kehkooi; Meng, Anming; Gao, Shaorong; Xu, Feng; Na, Jie^#; Xie, Wei^#.Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.NATURE. Sep 2016.
7. Zheng, Hui*; Huang, Bo*; Zhang, Bingjie*; Xiang, Yunlong; Du, Zhenhai; Xu, Qianhua; Li, Yuanyuan; Wang, Qiujun; Ma, Jing; Peng, Xu; Xu, Feng; Xie, Wei^#.Resetting epigenetic memory by reprogramming of histone modifications in mammals..MOLECULAR CELL. Sep 2016.
8. Wu, Jingyi*; Huang, Bo*; Chen, He; Yin, Qiangzong; Liu, Yang; Xiang, Yunlong; Zhang, Bingjie; Liu, Bofeng; Wang, Qiujun; Xia, Weikun; Li, Wenzhi; Li, Yuanyuan; Ma, Jing; Peng, Xu; Zheng, Hui; Ming, Jia; Zhang, Wenhao; Zhang, Jing; Tian, Geng; Xu, Feng; Chang, Zai; Na, Jie; Yang, Xuerui; Xie, Wei^#.The landscape of accessible chromatin in mammalian preimplantation embryos..NATURE. Jun 2016.

Hui Zheng, PhDAssistant Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo