Principal investigator
Name:
Hui ZhangAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2004.09-2008.06, College of Animal Sciences and Technology, Huazhong Agriculture University, B.S.A.
- 2008.09-2014.03, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Ph.D.
Working Experience:
- 2014.04-2016.03, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Postdoc
- 2016.04-2016.10, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Associate Investigator
- 2016.11-2022.09, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
- 2022.09-Present, School of Life Science and Technology, ShanghaiTech University, Associate Professor (TENURED)
Group Introduction
Research Area:
Cardiovascular Development and Regeneration
Research Interests:
Our laboratory investigates fundamental cell fate dynamics—including differentiation, proliferation, migration, and senescence—and the regulatory networks that govern them in the cardiovascular system across development, homeostasis, aging, and injury. We also delineate the mechanisms driving pathological cardiac remodeling post-injury. Building on these insights, we develop and validate therapeutic strategies to promote cardiomyocyte proliferation and regeneration, attenuate maladaptive fibrosis, and enhance functional coronary angiogenesis. Together, these efforts establish a mechanistic foundation for novel interventions against cardiac disease.
Representative Publications (*First Author, # Corresponding Author)
- 1. Lu, Zhengkai*; Zhou, Jian*; Ye, Min; Meng, Jufeng; Feng, Teng; Jiang, Zhen; Dai, Wenxuan; Deng, Defang; Wei, Yuanxin; Zhang, Wen; Zheng, Jialei; Fu, Yutao; Lin, Chao-Po; Chen, Huiwen; Shi, Guocheng#; Zhang, Hui#; Tang, Juan#.Cardiac mural cells are rate-limiting for coronary vascularization after heart injury.iScience. 2025. In press.
- 2. Kou, Shan*; Lu, Zhengkai*; Deng, Defang*; Ye, Min; Sui, Yu; Qin, Lieyang; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Lin, Chao-Po; Li, Xiajun; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Activation of imprinted gene PW1 promotes cardiac fibrosis after ischemic injury.CIRCULATION. 2025. 151(9):623-639.
- 3. Gao, Zibei*; Yan, Lei*; Meng, Jufeng*; Lu, Zhengkai; Ge, Kaixin; Jiang, Zhen; Feng, Teng; Wang, Haopeng; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Targeting cardiac fibrosis with chimeric antigen receptor macrophages.CELL DISCOVERY. 2024. 10 (86).
- 4. Gao, Zibei*; Lu, Zhengkai*; Meng, Jinyan; Lin, Chao-Po; Zhang, Hui#; Tang, Juan#.Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.STEM CELL RESEARCH & THERAPY. 2023. 14(161).
- 5. Huang, Xinyan*; Yan, Lei*; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan#; Zhu, Ping#; Zhang, Hui#.Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
- 6. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan#; Lin, Chao-Po#; Zhang, Hui#.Functions and origins of cardiac fat.FEBS JOURNAL. 2023. 290(7):1705-1718.
- 7. Jiang, Xiaoyu*; Feng, Teng*; An, Bolin; Ren, Susu; Meng, Jufeng; Li, Ke; Liu, Suying; Wu, Haiying; Zhang, Hui#; Zhong, Chao#.A bi-layer hydrogel cardiac patch made of recombinant functional proteins.ADVANCED MATERIALS. 2022. 34:e2201411.
- 8. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
- 9. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen#; Zhang, Hui#.PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 2021. 34(5):108697.
- 10. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui#.No evidence for erythro-myeloid progenitor-derived vascular endothelial cells in multiple organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
- 11. Feng, Teng*; Meng, Jufeng; Kou, Shan; Jiang, Zhen; Huang, Xinyan; Lu, Zhengkai; Zhao, Huan; Lau, Lester F.; Zhou, Bin#; Zhang, Hui#.CCN1-induced cellular senescence promotes heart regeneration.CIRCULATION. 2019. 139(21):2495-2498.
- 12. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
- 13. Zhang, Hui*#; Lui, Kathy O.#; Zhou, Bin#.Endocardial cell plasticity in cardiac development, diseases and regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
- 14. Zhang, Hui*; Huang, Xiuzhen*; Liu, Kuo*; Tang, Juan*; He, Lingjuan; Pu, Wenjuan; Liu, Qiaozhen; Li, Yan; Tian, Xueying; Wang, Yue; Zhang, Libo; Yu, Ying; Wang, Hongyan; Hu, Ronggui; Wang, Fengchao; Chen, Ting; Wang, Qing-Dong; Qiao, Zengyong; Zhang, Li; Lui, Kathy O.; Zhou, Bin#.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
- 15. Zhang, Hui*; Pu, Wenjuan; Tian, Xueying; Huang, Xiuzhen; He, Lingjuan; Liu, Qiaozhen; Li, Yan; Zhang, Libo; He, Liang; Liu, Kuo; Gillich, Astrid; Zhou, Bin#.Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
- 16. Zhang, Hui*; Pu, Wenjuan; Li, Guang; Huang, Xiuzhen; He, Lingjuan; Tian, Xueying; Liu, Qiaozhen; Zhang, Libo; Wu, Sean M.; Sucov, Henry M.; Zhou, Bin#.Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
- 17. Zhang, Hui*; Pu, Wenjuan; Liu, Qiaozhen; He, Lingjuan; Huang, Xiuzhen; Tian, Xueying; Zhang, Libo; Nie, Yu; Hu, Shengshou; Lui, Kathy O.; Zhou, Bin#.Endocardium contributes to cardiac fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
- 18. Zhang, Hui*; Von Gise, Alexander; Liu, Qiaozhen; Hu, Tianyuan; Tian, Xueying; He, Lingjuan; Pu, Wenjuan; Huang, Xiuzhen; He, Liang; Cai, Chen-Leng; Camargo, Fernando D.; Pu, William T.; Zhou, Bin#.Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion.JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289(27):18681-18692.
- 19. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan*; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhen; Yan, Yan; Yang, Xiao; Zhong, Tao P.; Pu, William T.; Zhou, Bin#.De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
- 20. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin#.Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.
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