Principal investigator
Name:
Hui ZhangAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2004.09-2008.06, College of Animal Sciences and Technology, Huazhong Agriculture University, B.S.A.
- 2008.09-2014.03, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Ph.D.
Working Experience:
- 2014.04-2016.03, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Postdoc
- 2016.04-2016.10, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Associate Investigator
- 2016.11-2022.09, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
- 2022.09-Present, School of Life Science and Technology, ShanghaiTech University, Associate Professor (TENURED)
Group Introduction
Research Area:
Cardiovascular Development and Regeneration
Research Interests:
We use single-cell sequencing, genetic lineage tracing, and gene manipulation techniques to investigate cell fate changes, such as differentiation, proliferation, migration, and senescence, as well as their regulatory mechanisms during cardiovascular development, growth, and aging. Our research also focuses on elucidating the mechanisms of cardiac remodeling following injury. Through these efforts, we aim to develop effective strategies to promote cardiomyocyte proliferation, reduce cardiac fibrosis, and stimulate coronary vascular angiogenesis following heart injury. This work provides the theoretical foundation for treating cardiac-related diseases, such as myocardial infarction and heart failure.
Representative Publications (*First Author, # Corresponding Author)
- 1. Kou, Shan*; Lu, Zhengkai*; Deng, Defang*; Ye, Min; Sui, Yu; Qin, Lieyang; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Lin, Chao-Po; Li, Xiajun; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury.CIRCULATION. 2025. 151(9):623-639.
- 2. Gao, Zibei*; Yan, Lei*; Meng, Jufeng*; Lu, Zhengkai; Ge, Kaixin; Jiang, Zhen; Feng, Teng; Wang, Haopeng; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Targeting cardiac fibrosis with chimeric antigen receptor macrophages.CELL DISCOVERY. 2024. 10 (86).
- 3. Gao, Zibei*; Lu, Zhengkai*; Meng, Jinyan; Lin, Chao-Po; Zhang, Hui#; Tang, Juan#; .Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.STEM CELL RESEARCH & THERAPY. 2023. 14(161).
- 4. Huang, Xinyan*; Yan, Lei*; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan#; Zhu, Ping#; Zhang, Hui#; .Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
- 5. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan#; Lin, Chao-Po#; Zhang, Hui#; .Functions and origins of cardiac fat.FEBS JOURNAL. 2023. 290(7):1705-1718.
- 6. Jiang, Xiaoyu*; Feng, Teng*; An, Bolin; Ren, Susu; Meng, Jufeng; Li, Ke; Liu, Suying; Wu, Haiying; Zhang, Hui#; Zhong, Chao#; .A Bi-layer Hydrogel Cardiac Patch Made of Recombinant Functional Proteins.ADVANCED MATERIALS. 2022. 34:e2201411.
- 7. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen#; Zhang, Hui#; .PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 2021. 34(5):108697.
- 8. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#; .Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
- 9. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui#; .No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
- 10. Feng, Teng*; Meng, Jufeng; Kou, Shan; Jiang, Zhen; Huang, Xinyan; Lu, Zhengkai; Zhao, Huan; Lau, Lester F.; Zhou, Bin#; Zhang, Hui#; .CCN1-Induced Cellular Senescence Promotes Heart Regeneration.CIRCULATION. 2019. 139(21):2495-2498.
- 11. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#; .Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
- 12. Zhang, Hui#*; Lui, Kathy O.#; Zhou, Bin#; .Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
- 13. Zhang, Hui#*; Huang, Xiuzhen*; Liu, Kuo*; Tang, Juan*; He, Lingjuan; Pu, Wenjuan; Liu, Qiaozhen; Li, Yan; Tian, Xueying; Wang, Yue; Zhang, Libo; Yu, Ying; Wang, Hongyan; Hu, Ronggui; Wang, Fengchao; Chen, Ting; Wang, Qing-Dong; Qiao, Zengyong; Zhang, Li; Lui, Kathy O.; Zhou, Bin#; .Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
- 14. Zhang, Hui*; Pu, Wenjuan; Li, Guang; Huang, Xiuzhen; He, Lingjuan; Tian, Xueying; Liu, Qiaozhen; Zhang, Libo; Wu, Sean M.; Sucov, Henry M.; Zhou, Bin#; .Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
- 15. Zhang, Hui*; Pu, Wenjuan; Tian, Xueying; Huang, Xiuzhen; He, Lingjuan; Liu, Qiaozhen; Li, Yan; Zhang, Libo; He, Liang; Liu, Kuo; Gillich, Astrid; Zhou, Bin#; .Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
- 16. Zhang, Hui*; Pu, Wenjuan; Liu, Qiaozhen; He, Lingjuan; Huang, Xiuzhen; Tian, Xueying; Zhang, Libo; Nie, Yu; Hu, Shengshou; Lui, Kathy O.; Zhou, Bin#; .Endocardium Contributes to Cardiac Fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
- 17. Zhang, Hui*; Von Gise, Alexander; Liu, Qiaozhen; Hu, Tianyuan; Tian, Xueying; He, Lingjuan; Pu, Wenjuan; Huang, Xiuzhen; He, Liang; Cai, Chen-Leng; Camargo, Fernando D.; Pu, William T.; Zhou, Bin#; .Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion.JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289(27):18681-18692.
- 18. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan*; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhen; Yan, Yan; Yang, Xiao; Zhong, Tao P.; Pu, William T.; Zhou, Bin#; .De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
- 19. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin#; .Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.
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