英文信息

Principal investigator

Name:

Hui ZhangAssociate Professor , PhD, Associate Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:

2004.09-2008.06, College of Animal Sciences and Technology, Huazhong Agriculture University, B.S.A.
2008.09-2014.03, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Ph.D.

Working Experience:

2014.04-2016.03, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Postdoc
2016.04-2016.10, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Associate Investigator
2016.11-2022.09, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
2022.09-Present, School of Life Science and Technology, ShanghaiTech University, Associate Professor (TENURED)

Group Introduction

Research Area:

Cardiac Injury, Regeneration, and Repair

Research Interests:

Our laboratory focuses on the pathological remodeling process following cardiac injury. By investigating cellular fate changes and intercellular interaction mechanisms, we explore novel intervention targets and strategies to promote myocardial regeneration, achieve targeted modulation of fibrosis, and induce functional angiogenesis. The ultimate goal is to provide a biological foundation and translational basis for the treatment of cardiac diseases such as myocardial infarction and heart failure.

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Lei Yan*; Jialei Zheng*; Zhengkai Lu*; Anqi Zhu; Min Ye; Jufeng Meng; Juan Tang^#; Hui Zhang^#.P16+ cells drive adverse postischemic cardiac remodeling through CCL8-mediated recruitment of cytotoxic lymphocytes.CIRCULATION. 2026. 153 (18):1385-1401.
2. Shan Kou*; Zhengkai Lu*; Defang Deng*; Min Ye; Yu Sui; Lieyang Qin; Teng Feng; Zhen Jiang; Jufeng Meng; Chao-Po Lin; Xiajun Li; Chen Liu^#; Juan Tang^#; Hui Zhang^#.Activation of imprinted gene PW1 promotes cardiac fibrosis after ischemic injury.CIRCULATION. 2025. 151(9):623-639.
3. Zibei Gao*; Lei Yan*; Jufeng Meng*; Zhengkai Lu; Kaixin Ge; Zhen Jiang; Teng Feng; Haopeng Wang; Chen Liu^#; Juan Tang^#; Hui Zhang^#.Targeting cardiac fibrosis with chimeric antigen receptor macrophages.CELL DISCOVERY. 2024. 10 (86).
4. Xiaoyu Jiang*; Teng Feng*; Bolin An; Susu Ren; Jufeng Meng; Ke Li; Suying Liu; Haiying Wu; Hui Zhang^#; Chao Zhong^#.A bi-layer hydrogel cardiac patch made of recombinant functional proteins.ADVANCED MATERIALS. 2022. 34:e2201411.
5. Zhen Jiang*; Zhengkai Lu; Shan Kou; Teng Feng; Yuanxin Wei; Zibei Gao; Defang Deng; Jufeng Meng; Chao-Po Lin; Bin Zhou; Hui Zhang^#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
6. Teng Feng*; Zibei Gao*; Shan Kou; Xinyan Huang; Zhen Jiang; Zhengkai Lu; Jufeng Meng; Chao-Po Lin; Hui Zhang^#.No evidence for erythro-myeloid progenitor-derived vascular endothelial cells in multiple organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
7. Teng Feng*; Jufeng Meng; Shan Kou; Zhen Jiang; Xinyan Huang; Zhengkai Lu; Huan Zhao; Lester F. Lau; Bin Zhou^#; Hui Zhang^#.CCN1-induced cellular senescence promotes heart regeneration.CIRCULATION. 2019. 139(21):2495-2498.
8. Hui Zhang*^#; Kathy O. Lui^#; Bin Zhou^#.Endocardial cell plasticity in cardiac development, diseases and regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
9. Hui Zhang*^#; Xiuzhen Huang*; Kuo Liu*; Juan Tang*; Lingjuan He; Wenjuan Pu; Qiaozhen Liu; Yan Li; Xueying Tian; Yue Wang; Libo Zhang; Ying Yu; Hongyan Wang; Ronggui Hu; Fengchao Wang; Ting Chen; Qing-Dong Wang; Zengyong Qiao; Li Zhang; Kathy O. Lui; Bin Zhou^#.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
10. Hui Zhang*; Wenjuan Pu; Xueying Tian; Xiuzhen Huang; Lingjuan He; Qiaozhen Liu; Yan Li; Libo Zhang; Liang He; Kuo Liu; Astrid Gillich; Bin Zhou^#.Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
11. Hui Zhang*; Wenjuan Pu; Guang Li; Xiuzhen Huang; Lingjuan He; Xueying Tian; Qiaozhen Liu; Libo Zhang; Sean M. Wu; Henry M. Sucov; Bin Zhou^#.Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
12. Hui Zhang*; Wenjuan Pu; Qiaozhen Liu; Lingjuan He; Xiuzhen Huang; Xueying Tian; Libo Zhang; Yu Nie; Shengshou Hu; Kathy O. Lui; Bin Zhou^#.Endocardium contributes to cardiac fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
13. Xueying Tian*; Tianyuan Hu*; Hui Zhang*; Lingjuan He*; Xiuzhen Huang; Qiaozhen Liu; Wei Yu; Liang He; Zhen Yang; Yan Yan; Xiao Yang; Tao P. Zhong; William T. Pu; Bin Zhou^#.De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
14. Xueying Tian*; Tianyuan Hu*; Hui Zhang*; Lingjuan He; Xiuzhen Huang; Qiaozhen Liu; Wei Yu; Liang He; Zhongzhou Yang; Zhen Zhang; Tao P. Zhong; Xiao Yang; Zhen Yang; Yan Yan; Antonio Baldini; Yunfu Sun; Jie Lu; Robert J. Schwartz; Sylvia M. Evans; Adriana C. Gittenberger-de Groot; Kristy Red-Horse; Bin Zhou^#.Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.

Hui Zhang, PhDAssociate Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo