Principal investigator
Name:
Hui ZhangAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2004.09-2008.06, College of Animal Sciences and Technology, Huazhong Agriculture University, B.S.A.
- 2008.09-2014.03, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Ph.D.
Working Experience:
- 2014.04-2016.03, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Postdoc
- 2016.04-2016.10, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Associate Investigator
- 2016.11-2022.09, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
- 2022.09-Present, School of Life Science and Technology, ShanghaiTech University, Associate Professor (TENURED)
Group Introduction
Research Area:
Cardiovascular Development and Regeneration
Research Interests:
(1) We focus on elucidating the regulatory principles of cell fate in the cardiovascular system during development, growth, and aging. By integrating genetic lineage tracing, multi-omics analyses, and genetic manipulation techniques, we aim to uncover the regulatory networks governing cell differentiation, proliferation, migration, and senescence. (2) We investigate pathological cardiac remodeling following injury and develop novel therapeutic strategies. Our research aims to reverse adverse remodeling by promoting myocardial regeneration, inhibiting fibrosis, and inducing angiogenesis, ultimately providing new therapeutic targets and approaches for conditions such as myocardial infarction and heart failure. (3) We develop novel mouse genetic tools to support the above research. Through innovative application of recombinase systems, including Cre/loxP and Dre/rox, we engineer mouse models for high-resolution dissection of cell lineages and intercellular interactions.
Representative Publications (*First Author, # Corresponding Author)
- 1. Yan, Lei*; Zheng, Jialei*; Lu, Zhengkai*; Zhu, Anqi; Ye, Min; Meng, Jufeng; Tang, Juan#; Zhang, Hui#.P16-positive cells drive adverse post-ischemic cardiac remodeling through CCL8-mediated recruitment of cytotoxic lymphocytes.CIRCULATION. 2026. 153 (Ahead of print).
- 2. Kou, Shan*; Lu, Zhengkai*; Deng, Defang*; Ye, Min; Sui, Yu; Qin, Lieyang; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Lin, Chao-Po; Li, Xiajun; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Activation of imprinted gene PW1 promotes cardiac fibrosis after ischemic injury.CIRCULATION. 2025. 151(9):623-639.
- 3. Lu, Zhengkai*; Zhou, Jian*; Ye, Min; Meng, Jufeng; Feng, Teng; Jiang, Zhen; Dai, Wenxuan; Deng, Defang; Wei, Yuanxin; Zhang, Wen; Zheng, Jialei; Fu, Yutao; Lin, Chao-Po; Chen, Huiwen; Shi, Guocheng#; Zhang, Hui#; Tang, Juan#.Cardiac mural cells are rate-limiting for coronary vascularization after heart injury.iScience. 2025. 28(10):113536.
- 4. Gao, Zibei*; Yan, Lei*; Meng, Jufeng*; Lu, Zhengkai; Ge, Kaixin; Jiang, Zhen; Feng, Teng; Wang, Haopeng; Liu, Chen#; Tang, Juan#; Zhang, Hui#.Targeting cardiac fibrosis with chimeric antigen receptor macrophages.CELL DISCOVERY. 2024. 10 (86).
- 5. Huang, Xinyan*; Yan, Lei*; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan#; Zhu, Ping#; Zhang, Hui#.Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
- 6. Gao, Zibei*; Lu, Zhengkai*; Meng, Jinyan; Lin, Chao-Po; Zhang, Hui#; Tang, Juan#.Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.STEM CELL RESEARCH & THERAPY. 2023. 14(161).
- 7. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan#; Lin, Chao-Po#; Zhang, Hui#.Functions and origins of cardiac fat.FEBS JOURNAL. 2023. 290(7):1705-1718.
- 8. Jiang, Xiaoyu*; Feng, Teng*; An, Bolin; Ren, Susu; Meng, Jufeng; Li, Ke; Liu, Suying; Wu, Haiying; Zhang, Hui#; Zhong, Chao#.A bi-layer hydrogel cardiac patch made of recombinant functional proteins.ADVANCED MATERIALS. 2022. 34:e2201411.
- 9. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
- 10. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen#; Zhang, Hui#.PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 2021. 34(5):108697.
- 11. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui#.No evidence for erythro-myeloid progenitor-derived vascular endothelial cells in multiple organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
- 12. Feng, Teng*; Meng, Jufeng; Kou, Shan; Jiang, Zhen; Huang, Xinyan; Lu, Zhengkai; Zhao, Huan; Lau, Lester F.; Zhou, Bin#; Zhang, Hui#.CCN1-induced cellular senescence promotes heart regeneration.CIRCULATION. 2019. 139(21):2495-2498.
- 13. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
- 14. Zhang, Hui*#; Lui, Kathy O.#; Zhou, Bin#.Endocardial cell plasticity in cardiac development, diseases and regeneration.CIRCULATION RESEARCH. 2018. 122(5):774-789.
- 15. Zhang, Hui*#; Huang, Xiuzhen*; Liu, Kuo*; Tang, Juan*; He, Lingjuan; Pu, Wenjuan; Liu, Qiaozhen; Li, Yan; Tian, Xueying; Wang, Yue; Zhang, Libo; Yu, Ying; Wang, Hongyan; Hu, Ronggui; Wang, Fengchao; Chen, Ting; Wang, Qing-Dong; Qiao, Zengyong; Zhang, Li; Lui, Kathy O.; Zhou, Bin#.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.CELL RESEARCH. 2017. 27(9):1157-1177.
- 16. Zhang, Hui*; Pu, Wenjuan; Tian, Xueying; Huang, Xiuzhen; He, Lingjuan; Liu, Qiaozhen; Li, Yan; Zhang, Libo; He, Liang; Liu, Kuo; Gillich, Astrid; Zhou, Bin#.Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS. 2016. 48(5):537-543.
- 17. Zhang, Hui*; Pu, Wenjuan; Li, Guang; Huang, Xiuzhen; He, Lingjuan; Tian, Xueying; Liu, Qiaozhen; Zhang, Libo; Wu, Sean M.; Sucov, Henry M.; Zhou, Bin#.Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls.CIRCULATION RESEARCH. 2016. 118(12):1880-1893.
- 18. Zhang, Hui*; Pu, Wenjuan; Liu, Qiaozhen; He, Lingjuan; Huang, Xiuzhen; Tian, Xueying; Zhang, Libo; Nie, Yu; Hu, Shengshou; Lui, Kathy O.; Zhou, Bin#.Endocardium contributes to cardiac fat.CIRCULATION RESEARCH. 2016. 118(2):254-265.
- 19. Zhang, Hui*; Von Gise, Alexander; Liu, Qiaozhen; Hu, Tianyuan; Tian, Xueying; He, Lingjuan; Pu, Wenjuan; Huang, Xiuzhen; He, Liang; Cai, Chen-Leng; Camargo, Fernando D.; Pu, William T.; Zhou, Bin#.Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion.JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289(27):18681-18692.
- 20. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan*; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhen; Yan, Yan; Yang, Xiao; Zhong, Tao P.; Pu, William T.; Zhou, Bin#.De novo formation of a distinct coronary vascular population in neonatal heart.SCIENCE. 2014. 345(6192):90-94.
- 21. Tian, Xueying*; Hu, Tianyuan*; Zhang, Hui*; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin#.Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH. 2013. 23(9):1075-1090.
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