英文信息

Nutrient, metabolism and animal development

Principal investigator

Name:

Huanhu ZhuAssociate Professor , PhD, Associate Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:

1998-2002, Fudan University CHINA, B.S.
2002-2010, Fudan University CHINA, Ph.D.

Working Experience:

2009-2015, University of Colorado Boulder, HHMI, Research associate
2015/11-Present, ShanghaiTech University, Assistant Professor (TENURE-TRACK)

Group Introduction

Research Area:

Environment Factors on Developmental Regulation

Research Interests:

The interplay between animal and the environment helped to shape the physiological and developmental program in animals. To better understand this process, we apply a nematode C. elegans model to study the role of several key environmental factors such as nutrient molecule, pheromone and gut bacteria. We are surprised to find those environments play vital roles and fundamentally arbitrate the animal developmental fate and the native immunity

Homepage of Zhu Lab:www.zhulab-shanghaitech.com

Group Website:

http://www.zhulab-shanghaitech.com

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Zhu, Mengnan*; Teng, Fukang; Li, Na; Zhang, Li; Zhang, Shuxian; Xu, Fan; Shao, Jing; Sun, Haipeng; Zhu, Huanhu^#.Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1.DEVELOPMENTAL CELL. 11 Oct 2021. 56(19):2692-+.
2. Liu, Yalei*; Zhou, Zhenyu; Yin, Liufang; Zhu, Mengnan; Wang, Fei; Zhang, Lijun; Wang, Hongqing; Zhou, Zhiqin; Zhu, Huanhu^#; Huang, Cheng^#; Fan, Shengjie^#.Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans.BIOFACTORS. Mar 2022.
3. Wang, Feng*; Dai, Yuxi; Zhu, Xufeng; Chen, Qilong; Zhu, Huanhu; Zhou, Ben; Tang, Haiqing^#; Pang, Shanshan^#.Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans.NATURE COMMUNICATIONS. 20 Aug 2021. 12(1).
4. Zhang, Yang*; Sun, Xiaodan; Qian, Yangyang; Yi, Hongfei; Song, Ke; Zhu, Huanhu; Zonta, Francesco; Chen, Weizhong; Ji, Quanjiang; Miersch, Shane; Sidhu, Sachdev S.^#; Wu, Donghui^#.A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa.JOURNAL OF MOLECULAR BIOLOGY. 06 Dec 2019. 431(24):4882-4896.
5. Mao, Shaoshuai*; Qi, Yingchuan; Zhu, Huanhu; Huang, Xinxin; Zou, Yan; Chi, Tian^#.A Tet/Q Hybrid System for Robust and Versatile Control of Transgene Expression in C. elegans.ISCIENCE. 25 Jan 2019. 11:224-+.
6. Zhu HH(朱焕乎)^#*.Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans.WORM. 04 May 2016.
7. Zhu, Huanhu^#*; Sewell, Aileen K.*; Han, Min.Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans.GENES & DEVELOPMENT. 2015. 29(12):1218-1223.
8. Kniazeva, Marina^#*; Zhu, Huanhu; Sewell, Aileen K.; Han, Min^#.A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans.DEVELOPMENTAL CELL. 2015. 33(3):260-271.
9. Zhu, Huanhu^#*; Han, Min.Exploring Developmental and Physiological Functions of Fatty Acid and Lipid Variants Through Worm and Fly Genetics.ANNUAL REVIEW OF GENETICS. 2014. 48:119-148.
10. Zhu, Huanhu*; Shen, Huali; Sewell, Aileen K.; Kniazeva, Marina; Han, Min^#.A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.ELIFE. 2013. 2.
11. Chi, Congwu*; Zhu, Huanhu*; Han, Min; Zhuang, Yuan; Wu, Xiaohui^#; Xu, Tian^#.Disruption of Lysosome Function Promotes Tumor Growth and Metastasis in Drosophila.JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285(28):21817-21823.

Monograph

Patent

Funding

1. Shanghai Pujiang program (16PJ1407400), Shanghai Municipal Science and Technology Commission, Leader
2. National Key R&D Program (2019YFA0802804), Ministry of Science and Technology, Participator

Huanhu Zhu, PhDAssociate Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo