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Heqiao Zhang, PhDAssistant Professor

Tel:

Email: zhanghq@@shanghaitech.edu.cn

Fax:

Add: Room C404, Y Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China

Faculty KMS Profile

中文信息English
Laboratory of Structural Virology and RNA Biology

Principal investigator

Name:

Heqiao ZhangAssistant Professor , PhD, Assistant Professor

Position:

Principal Investigator, Tenure-track Assistant Professor

Affiliation:

Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology

Honor:

Education Background:
  • 2006-2010, Hebei University of Technology, Bachelor
  • 2013-2016, Institute of Biophysics, Chinese Academy of Sciences, Master
  • 2013-2016, Tsinghua University, Doctor
Working Experience:
  • 2016/07-2016/12, Shanghai Hengrui Pharmaceutical Co., Ltd., Senior Research Scientist
  • 2017/01-2021/08, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Research Assistant Professor
  • 2017/12-2018/06, Stanford University School of Medicine, Visiting Associate Professor
  • 2019/04-2020/09, Stanford University School of Medicine, Visiting Associate Professor
  • 2021/08-2025/12, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Research Associate Professor, Co-Principal Investigator
  • 2025/12-Now, Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology, Principal Investigator & Tenure-track Assistant Professor

Group Introduction

Research Area:
Replication/transcription mechanisms in viruses and eukaryotes; antiviral drug development
Research Interests:

Transcription and replication mechanisms of RNA viruses, antiviral drug development.

Group Website:

Research Achievement

  1. Determined the cryo-EM structures of the measles virus polymerase bound to two non-nucleoside inhibitors (ERDRP-0519 and AS-136A).
    These structures reveal the allosteric regulatory mechanisms by which non-nucleoside inhibitors suppress the polymerase activities of measles and Nipah viruses. Using structural and biochemical approaches, we also identified non-nucleoside inhibitors that target the Nipah virus polymerase (Cell, 2025).

  2. Resolved the high-resolution cryo-EM structure of the Nipah virus polymerase complex in a resting state.
    This work uncovered the conserved molecular mechanism by which non-segmented negative-sense RNA viruses recognize their template RNA, and identified evolutionarily mutable amino-acid positions within the Nipah virus polymerase subunits (Science Advances, 2024).

  3. Elucidated the molecular mechanisms governing histone acetylation and deacetylation by the eukaryotic protein complexes NuA4, NuA3, and Clr6S/Rpd3S (Nature Communications, 2025; PNAS, 2023; PNAS, 2022).

  4. Determined the high-resolution cryo-EM structure of the eukaryotic transcription coactivator–Mediator complex, providing insights into the potential molecular mechanism by which the Mediator complex regulates RNA polymerase II transcription (Molecular Cell, 2021).


Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

  • 1. 2025, Shanghai Leading Talent Program of Eastern Talent Plan
  • 2. 2025, Young Scientist Presentation Award of the 11th East China Structural Biology Conference
  • 3. 2025, First Prize for Best Presentation of the Shanghai Society for Biochemistry and Molecular Biology

Research Achievement

Group Member and Photo

  • Name：Yinglin Yuan
    Position：Postgraduate Student
    Duration：2025/12-Now
    Email：
  • Name：Yuqing Wu
    Position：Postgraduate Student
    Duration：2025/12-Now
    Email：
  • Name：Wenqi Wang
    Position：Postgraduate Student
    Duration：2025/12-Now
    Email：
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