课题组长
姓名:
钟劲中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务:
所在院所:
生命科学与技术学院、中科院上海巴斯德研究所
荣誉称号:
课题组简介
研究内容:
丙型肝炎病毒(HCV)能导致急性和慢性肝炎以及肝癌,并且已成为一个世界性的人类健康问题。目前还没有预防HCV感染的疫苗,而慢性丙肝感染的治疗手段有限。我们实验室的主要研究方向是研究HCV感染过程中病毒和宿主之间的相互作用以及病毒诱导和调控宿主先天性免疫反应的机制。我们希望通过进一步了解病毒感染宿主细胞的生物学机制以及宿主是如何限制病毒的感染,找到更好的途径和手段来预防和治疗HCV的感染。 |
代表性论文(*第一作者,#通讯作者)
- 1. Ding, Qiang*; Huang, Bing; Lu, Jie; Liu, Yong-Jun; Zhong, Jin#.Hepatitis C virus NS3/4A protease blocks IL-28 production.EUROPEAN JOURNAL OF IMMUNOLOGY. 2012. 42(9):2374-2382.
- 2. He, Ying*; Weng, Leiyun; Li, Rui; Li, Li; Toyoda, Tetsuya; Zhong, Jin#.The N-terminal helix alpha(0) of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex.VIROLOGY. 2012. 422(2):214-223.
- 3. Li, Rui*; Qin, Yan; He, Ying; Tao, Wanyin; Zhang, Nan; Tsai, Cheguo; Zhou, Paul; Zhong, Jin#.Production of Hepatitis C Virus Lacking the Envelope-Encoding Genes for Single-Cycle Infection by Providing Homologous Envelope Proteins or Vesicular Stomatitis Virus Glycoproteins in trans.JOURNAL OF VIROLOGY. 2011. 85(5):2138-2147.
- 4. Xiang, Xiaogang*; Lu, Jie; Dong, Zhixia; Zhou, Huijuan; Tao, Wanyin; Guo, Qing; Zhou, Xiaqiu; Bao, Shisan; Xie, Qing#; Zhong, Jin#.Viral sequence evolution in Chinese genotype 1b chronic hepatitis C patients experiencing unsuccessful interferon treatment.INFECTION GENETICS AND EVOLUTION. 2011. 11(2):382-39.
- 5. Tao, Wanyin*; Xu, Chunliang; Ding, Qiang; Li, Rui; Xiang, Yu; Chung, Josan; Zhong, Jin#.A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles.VIROLOGY. 2009. 395(1):67-76.
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