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Jian Zhao, PhDAssociate Professor

Tel:

Email: zhaojian@@shanghaitech.edu.cn

Fax: 86-21-20685430

Add: 393 Middle Huaxia Road, Pudong, Shanghai

Faculty KMS Profile

中文信息English
Lab of Regenerative Medicine and Neural Repair

Principal investigator

Name:

Jian ZhaoAssociate Professor , PhD, Associate Professor

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Institute

Honor:

Education Background:
  • 1992/09-1996/07, Fudan University, Shanghai, China, B.S.
  • 1996/09-1999/07, Shanghai Institute of Cell Biology, Chinese Academy of Sciences, M.S.
  • 2000/10-2004/01, The Ruperto-Carola University of Heidelberg, Germany, Ph.D.
Working Experience:
  • 1996/07-2000/09, Young Scientists Group, Max-Planck Guest Laboratory, Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Assistant Research Professor
  • 2000/10-2004/01, German Cancer Research Center, Heidelberg, Germany, PhD candidate, Research assistant
  • 2004/02-2007/01, German Cancer Research Center, Heidelberg, Germany, Post Doctoral Fellow, Scientist
  • 2007/02-2016/02, Lab of Cell Signaling, Institute of Biochemistry and cell biology, Shanghai Institutes for Biology Sciences (SIBS), Chinese Academy of Sciences (CAS), Associate Professor
  • 2015/06-2018/07, Stem cell core facility, Shanghai East Hospital, Tongji University School of Medicine , Director
  • 2016/03-2018/04, Institute for Advanced Study, Tongji University, Shanghai, China, Professor
  • 2018/05-2019/02, School of Medicine, Tongji University, Shanghai, China, Professor
  • 2019/03-Present, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), School of Life Science and Technology, ShanghaiTech University, Shanghai, Associate Professor

Group Introduction

Research Area:
New Mechanisms, New Drug Targets and New Therapeutic Strategies against Dementia Translational Research
Research Interests:

In more than a decade of research, I have focused on the study of new mechanisms of important signal transduction pathways in cell fate determination as well as in the pathogenesis and progression of neurodegenerative diseases. Our major findings include:


1. Established a novel chemical-induced transdifferentiation technology, providing induced human neural (progenitor) cells for disease-modeling. A series of in vitro small molecule transdifferentiation induction systems were established, and the possible general formula of transdifferentiation was proposed, by which exploration of the regulatory mechanisms of neurodegenerative diseases with human cells become possible.


2. Elucidated that the secretase protein complex as the key regulators of the development and progression of the Alzheimer’s diseases, providing a unique path for finding novel drugs that affects Aβ production and metabolism by various signal transduction proteins or protein complexes on the cell surface. We found that cell surface receptors, secretases and their regulatory proteins form functional secretase protein complexes (holo-secretase complex). Our results show that assembly of these secretase complex mediates the production of pathogenic β-amyloid, whereas intervention of which retards the generation of β-amyloid and Alzheimer's disease process. Our studies not only reveal new regulatory molecules in AD pathogenesis but propose new therapeutic strategies against the disease.


Our efforts will continue to focus on elucidating new mechanisms of key signal transduction pathways mediating the pathogenesis and progression of neurodegenerative diseases based on our previous achievements.


Direction I. Generating induced human neural (progenitor) cells as disease-modeling system.


Direction II. Cellular surface protein complexes as novel targets for the Alzheimer's disease.


Direction III. Exploring the multiple etiological characteristics of neurodegenerative diseases and new strategies for systematic treatment with multiple targets


Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo

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