课题组长
姓名：
周金秋中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
课题组简介
研究内容：
实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。目前主要用端粒作为特别的切入点来研究一些基础问题，比如端粒是如何保持染色体稳定性的；在常染色质和异染色质之间的边界是如何建立的；DNA双链损伤或端粒复制发生时所产生的表观遗传信息是什么；细胞衰老的分子基础又是什么。
代表性论文（*第一作者，#通讯作者）
- 1. Zhou, Bo O.#*; Wang, Shan-Shan; Zhang, Yang; Fu, Xiao-Hong; Dang, Wei; Lenzmeier, Brian A.; Zhou, Jin-Qiu#.Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae.PLOS GENETICS. 2011. 7(1).
- 2. Zhou, Bo O.*; Wang, Shan-Shan; Xu, Lu-Xia; Meng, Fei-Long; Xuan, Yao-Ji; Duan, Yi-Min; Wang, Jian-Yong; Hu, Hao; Dong, Xianchi; Ding, Jianping; Zhou, Jin-Qiu#.SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation.MOLECULAR AND CELLULAR BIOLOGY. 2010. 30(10):2391-24.
- 3. Zhang, Ming-Liang*; Tong, Xia-Jing; Fu, Xiao-Hong; Zhou, Bo O.; Wang, Jianyong; Liao, Xin-Hua; Li, Qian-Jin; Shen, Ning; Ding, Jianping; Zhou, Jin-Qiu#.Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2010. 17(2):202.
- 4. Meng, Fei-Long*; Hu, Yan; Shen, Ning; Tong, Xia-Jing; Wang, Jianyong; Ding, Jianping; Zhou, Jin-Qiu#.Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.EMBO JOURNAL. 2009. 28(10):1466-1478.
- 5. Chen, Xiao-Fen#*; Meng, Fei-Long; Zhou, Jin-Qiu#.Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae.PLOS GENETICS. 2009. 5(6).
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