Principle Investigator
Name:
Min ZhuangAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Ubiquitination
Research Interests:
| We are using a multi-disciplinary approach to study membrane-based ubiquitin ligases and their role in regulating organelle function. |
Representative Publications (*First Author, # Corresponding Author)
- 1. Sun, Weiping*; Huo, Yinbo; Mei, Yuxuan; Zhou, Qingtong; Zhao, Suwen; Zhuang, Min#.Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling.ACS CHEMICAL BIOLOGY. Jan 2020. 15(1):39-43.
- 2. Zhang Ziheng*; Sun Weiping; Shi Tiezhu; Lu Pengfei#; Zhuang Min#; Liu Ji-Long#.Capturing RNA-protein Interaction via CRUIS.NUCLEIC ACIDS RESEARCH. 06 Mar 2020. 48(9):e52.
- 3. Xue, Dongxiang*; Ye, Lintao; Zheng, Jun; Wu, Yiran; Zhang, Xianjun; Xu, Yueming; Li, Tao; Stevens, Raymond C.; Xu, Fei; Zhuang, Min; Zhao, Suwen; Zhao, Fei#; Tao, Houchao#.The structure-based traceless specific fluorescence labeling of the smoothened receptor.ORGANIC & BIOMOLECULAR CHEMISTRY. 07 Jul 2019. 17(25):6136-6142.
- 4. Liu, Qiang*; Zheng, Jun; Sun, Weiping; Huo, Yinbo; Zhang, Liye; Hao, Piliang; Wang, Haopeng#; Zhuang, Min#.A proximity-tagging system to identify membrane protein-protein interactions.NATURE METHODS. Sep 2018. 15(9):715-+.
- 5. Hill, Zachary B.*; Pollock, Samuel B.; Zhuang, Min; Wells, James A.#.Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 12 Oct 2016. 138(40):13123-13126.
- 6. Srinivasan, Sharan R.*; Cesa, Laura C.; Li, Xiaokai; Julien, Olivier; Zhuang, Min; Shao, Hao; Chung, Jooho; Maillard, Ivan; Wells, James A.; Duckett, Colin S.; Gestwicki, Jason E.#.Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.MOLECULAR CANCER RESEARCH. 2018. 16(1):58-68.
- 7. Julien, Olivier*; Zhuang, Min; Wiita, Arun P.; O'Donoghue, Anthony J.; Knudsen, Giselle M.; Craik, Charles S.; Wells, James A.#.Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 05 Apr 2016. 113(14):E2001-E2010.
- 8. Li, Guoqiang*; Ci, Weimin; Karmakar, Subhradip; Chen, Ke; Dhar, Ruby; Fan, Zhixiang; Guo, Zhongqiang; Zhang, Jing; Ke, Yuwen; Wang, Lu; Zhuang, Min; Hu, Shengdi; Li, Xuesong; Zhou, Liqun; Li, Xianghong; Calabrese, Matthew F.; Watson, Edmond R.; Prasad, Sandip M.; Rinker-Schaeffer, Carrie; Eggener, Scott E.; Stricker, Thomas; Tian, Yong; Schulman, Brenda A.; Liu, Jiang#; White, Kevin P.#.SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.CANCER CELL. 2014. 25(4):455-468.
- 9. Crawford, Emily D.*; Seaman, Julia E.; Agard, Nick; Hsu, Gerald W.; Julien, Olivier; Mahrus, Sami; Huy Nguyen; Shimbo, Kazutaka; Yoshihara, Hikari A. I.; Zhuang, Min; Chalkley, Robert J.; Wells, James A.#.The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells.MOLECULAR & CELLULAR PROTEOMICS. 2013. 12(3):813-824.
- 10. Zhuang, Min*; Calabrese, Matthew F.; Liu, Jiang; Waddell, M. Brett; Nourse, Amanda; Hammel, Michal; Miller, Darcie J.; Walden, Helen; Duda, David M.; Seyedin, Steven N.; Hoggard, Timothy; Harper, J. Wade; White, Kevin P.; Schulman, Brenda A.#.Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.MOLECULAR CELL. 2009. 36(1):39-50.
- 11. Jin, Yi*; Zhuang, Min; Hendershot, Linda M.#.ERdj3, a Luminal ER DnaJ Homologue, Binds Directly to Unfolded Proteins in the Mammalian ER: Identification of Critical Residues.BIOCHEMISTRY. 2009. 48(1):41-49.
- 12. Lei, Liqun*; Chen, Hongquan; Xue, Wei; Yang, Bei; Hu, Bian; Wei, Jia; Wang, Lijie; Cui, Yiqiang; Li, Wei; Wang, Jianying; Yan, Lei; Shang, Wanjing; Gao, Jimin; Sha, Jiahao; Zhuang, Min; Huang, Xingxu; Shen, Bin#; Yang, Li#; Chen, Jia#.APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Jan 2018. 25(1):45-+.
- 13. Ke, Qiong*; Li, Weiqiang; Lai, Xingqiang; Chen, Hong; Huang, Lihua; Kang, Zhuang; Li, Kai; Ren, Jie; Lin, Xiaofeng; Zheng, Haiqing; Huang, Weijun; Ma, Yunhan; Xu, Dongdong; Chen, Zheng; Song, Xinming; Lin, Xinyi; Zhuang, Min; Wang, Tao; Zhuang, Fengfeng; Xi, Jianzhong; Mao, Frank Fuxiang; Xia, Huimin; Lahn, Bruce T.; Zhou, Qi#; Yang, Shihua#; Xiang, Andy Peng#.TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.CELL RESEARCH. Sep 2016. 26(9):1048-1061.
- 14. Zhao, Lei*; Hu, Bo; Zhang, Yinsheng; Song, Yuan; Lin, Dandan; Liu, Yonghao; Mei, Yu; Sandikin, Dedy; Sun, Weiping; Zhuang, Min; Liu, Haiyan#.An activation-induced IL-15 isoform is a natural antagonist for IL-15 function.SCIENTIFIC REPORTS. 11 May 2016. 6.
- 15. Wang, Yuetong*; Cao, Jian; Liu, Weiwei; Zhang, Jiali; Wang, Zuo; Zhang, Yiqun; Hou, Linjun; Chen, Shengmiao; Hao, Piliang; Zhang, Liye; Zhuang, Min; Yu, Yang; Li, Dake; Fan, Gaofeng#.Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating βcatenin.Journal of Biological Chemistry. 2019. 294(48):18306-18323.
- 16. Huang, Danny T.*; Zhuang, Min; Ayrault, Olivier; Schulman, Brenda A.#.Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2008. 15(3):280-287.
- 17. Huang, Danny T.*; Hunt, Harold W.; Zhuang, Min; Ohi, Melanie D.; Holton, James M.; Schulman, Brenda A.#.Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.NATURE. 2007. 445(7126):394-398.
- 18. Huang, DT*; Paydar, A; Zhuang, M; Waddell, MB; Holton, JM; Schulman, BA#.Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.MOLECULAR CELL. 2005. 17(3):341-350.
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