课题组长
姓名：
赵素文副教授 研究员 博士生导师, PhD, 副教授
职务：
所在院所：
生命科学与技术学院、iHuman研究所
荣誉称号：
教育经历：
-
1999/09—2004/07，中国科学技术大学，学士
-
2004/08—2009/10，美国哥伦比亚大学，博士
博士后及工作经历：
- 2009/10—2010/04，美国哥伦比亚大学，博士后
- 2010/05—2014/11，美国加州大学旧金山分校，博士后
- 2014/11—2022/01，上海科技大学生命科学与技术学院、iHuman研究所，助理教授（TENURE-TRACK）
- 2022/01—至今，上海科技大学生命科学与技术学院、iHuman研究所，副教授（TENURED）
课题组简介
研究方向：
计算生物学；计算化学；蛋白质序列-结构-功能关系
研究内容：
课题组主要致力于开发和应用各种计算化学和计算生物学方法来研究蛋白质序列-结构-功能关系关系。研究方向集中于两点： （1）膜蛋白的药物研发与机理研究； （2）酶的功能预测、机理研究以及代谢通路预测。
研究成果展示
我们通过残基接触打分（Residue-Residue Contact Score, RRCS)分析了A家族GPCR 200多个结构残基层面的构象变化，发现A家族GPCR共享一个由34个氨基酸残基对（35个残基）构成的激活通路，揭示了A家族GPCR的共同激活机制。 
Zhou Q, Yang D, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich EI, Liu ZJ, Stevens RC, Lambert NA, Babu MM*, Wang MW*, Zhao S*.Common activation mechanism of class A GPCRs. eLife. 2019 Dec 19;8. pii: e50279. doi: 10.7554/eLife.50279
Z基因组由四种核苷，ZTCG组成，其中的生物合成途径此前是未知的。通过生物信息学分析，我们确定了一个负责Z基因组合成的多酶系统，这些酶的功能已经在体外和体内得到验证。我们的研究表明，Z基因组噬菌体具有遍布全球，这些噬菌体可以感染蓝藻门、放线菌门和变形菌门的细菌。因此推测至少在35亿年前，具有ZTCG基因组的生物体很可能已经与具有ATCG基因组的生物体同时存在于地球上。Z基因组合成通路的阐明也将推动Z基因组相关的合成生物学的研究。
Zhou Y.; Xu X.; Wei Y.; Cheng Y.; Guo Y.; Khudyakov I.; Liu F.; He P.; Song Z.; Li Z.; Gao Y.; Ang E. L.; Zhao H.*; Zhang Y.*; Zhao S.*, A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science, 2021 April 30, 372(6541):512-516. doi:10.1126/science.abe4882.
我们从PDB晶体结构出发，筛选构建了一个含有8145个配体结合构象的高质量数据集。针对该数据集，我们计算了配体的构象张力能(Ligand conformational strain energy, LCSE)，为PDB中配体的LCSE提供了一个全面的画像，这将有助于配体构象生成，配体结合模式评估，以及通过减少张力能来进行先导化合物优化。
Tong J, Zhao S*.Large-Scale Analysis of Bioactive Ligand Conformational Strain Energy by Ab Initio Calculation.J Chem Inf Model. 2021 Mar 22;61(3):1180-1192. doi: 10.1021/acs.jcim.0c01197.
我们分别解析了结合部分激动剂以及拮抗剂的肾上腺素受体α2A晶体结构，同结合部分激动剂的结构比较，全激动剂会与Y3946.55形成氢键。我们发现在结合部分激动剂的肾上腺素受体α2A招募Gs的过程中ICL2扮演重要角色。同β肾上腺素受体相比， F4127.39在肾上腺素受体α2A至关重要。
Qu L, Zhou Q, Xu Y, Guo Y, Chen X, Yao D, Han GW, Liu ZJ, Stevens RC, Zhong G*, Wu D*, Zhao S*. Structural basis of the diversity of adrenergic receptors.Cell Rep. 2019 Dec 3;29(10):2929-2935.e4. doi: 10.1016/j.celrep.2019.10.088.
我们基于nhmmer开发了一个嗅觉受体注释工具Genome2OR,最终从1608个脊索动物基因组中注释出765248个嗅觉受体，其中有404426个功能基因以及360822个假基因。在注释数据的基础上，我们建立了一个名为脊索动物嗅觉受体数据库（Chordata Olfactory Receptor Database，CORD）的数据库，用于存档、分析和传播数据。
Han W, Wu Y, Zeng L, Zhao S*. Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR.Sci China Life Sci. 2022 Jun 10. doi: 10.1007/s11427-021-2081-6.
代表性论文（*第一作者，#通讯作者）
- 1. Zhou, Yan*; Xu, Xuexia; Wei, Yifeng; Cheng, Yu; Guo, Yu; Khudyakov, Ivan; Liu, Fuli; He, Ping; Song, Zhangyue; Li, Zhi; Gao, Yan; Ang, Ee Lui; Zhao, Huimin; Zhang, Yan; Zhao, Suwen.A widespread pathway for substitution of adenine by diaminopurine in phage genomes.SCIENCE. 2021. 372(6541):512-+.
- 2. Zhao, Suwen*; Wu, Beili; Stevens, Raymond C.#.Advancing Chemokine GPCR Structure Based Drug Discovery.STRUCTURE. 05 Mar 2019. 27(3):405-408.
- 3. Zhou, Qingtong*; Yang, Dehua; Wu, Meng; Guo, Yu; Guo, Wangjing; Zhong, Li; Cai, Xiaoqing; Dai, Antao; Jang, Wonjo; Shakhnovich, Eugene I.; Liu, Zhi-Jie; Stevens, Raymond C.; Lambert, Nevin A.; Babu, M. Madan#; Wang, Ming-Wei#; Zhao, Suwen#.Common activation mechanism of class A GPCRs.ELIFE. 19 Dec 2019. 8.
- 4. Lou, Ronghui*; Tang, Pan; Ding, Kang; Li, Shanshan; Tian, Cuiping; Li, Yunxia; Zhao, Suwen#; Zhang, Yaoyang#; Shui, Wenqing#.Hybrid spectral library combining DIA-MS data and a targeted virtual library substantially deepens the proteome coverage.ISCIENCE. 2020. 23(3):100903.
- 5. Zhao, Suwen*; Kumar, Ritesh; Sakai, Ayano; Vetting, Matthew W.; Wood, B. McKay; Brown, Shoshana; Bonanno, Jeffery B.; Hillerich, Brandan S.; Seidel, Ronald D.; Babbitt, Patricia C.#; Almo, Steven C.#; Sweedler, Jonathan V.#; Gerlt, John A.#; Cronan, John E.#; Jacobson, Matthew P.#.Discovery of new enzymes and metabolic pathways by using structure and genome context.NATURE. 2013. 502(7473):698+.
- 6. Zhou, Jianhong*; Zhao, Suwen#; Dunker, A. Keith#.Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation.JOURNAL OF MOLECULAR BIOLOGY. 03 Aug 2018. 430(16):2342-2359.
- 7. Liu, Xuyang*; Gao, Zhan-Guo; Wu, Yiran; Stevens, Raymond C.; Jacobson, Kenneth A.; Zhao, Suwen#.Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors.SCIENTIFIC REPORTS. 24 May 2018. 8.
- 8. Hua, Tian*; Vemuri, Kiran; Nikas, Spyros P.; Laprairie, Robert B.; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A.; Zhao, Suwen#; Bohn, Laura M.#; Makriyannis, Alexandros#; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal structures of agonist-bound human cannabinoid receptor CB1.NATURE. 27 Jul 2017. 547(7664):468-+.
- 9. Zhou, Fang*; Ding, Kang; Zhou, Yiqing; Liu, Yang; Liu, Xiaoyan; Zhao, Fei; Wu, Yiran; Zhang, Xianjun; Tan, Qiwen; Xu, Fei; Tan, Wenfu; Xiao, Youli#; Zhao, Suwen#; Tao, Houchao#.Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor.JOURNAL OF MEDICINAL CHEMISTRY. 14 Nov 2019. 62(21):9983-9989.
- 10. Qu, Lu*; Zhou, Qingtong; Xu, Yueming; Guo, Yu; Chen, Xiaoyu; Yao, Deqiang; Han, Gye Won; Liu, Zhi-Jie; Stevens, Raymond C.; Zhong, Guisheng#; Wu, Dong#; Zhao, Suwen#.Structural Basis of the Diversity of Adrenergic Receptors.CELL REPORTS. 03 Dec 2019. 29(10):2929-+.
- 11. Chen, Xiaoyu*; Xu, Yueming; Qu, Lu; Wu, Lijie; Han, Gye Won; Guo, Yu; Wu, Yiran; Zhou, Qingtong; Sun, Qianqian; Chu, Cenfeng; Yang, Jie; Yang, Liu; Wang, Quan; Yuan, Shuguang; Wang, Ling; Hu, Tao; Tao, Houchao; Sun, Yaping; Song, Yunpeng; Hu, Liaoyuan; Liu, Zhi-Jie; Stevens, Raymond C.; Zhao, Suwen#; Wu, Dong#; Zhong, Guisheng#.Molecular Mechanism for Ligand Recognition and Subtype Selectivity of alpha(2C) Adrenergic Receptor.CELL REPORTS. 03 Dec 2019. 29(10):2936-+.
- 12. Zhao, Suwen*; Sakai, Ayano; Zhang, Xinshuai; Vetting, Matthew W.; Kumar, Ritesh; Hillerich, Brandan; San Francisco, Brian; Solbiati, Jose; Steeves, Adam; Brown, Shoshana; Akiva, Eyal; Barber, Alan; Seidel, Ronald D.; Babbitt, Patricia C.#; Almo, Steven C.#; Gerlt, John A.#; Jacobson, Matthew P.#.Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks.ELIFE. 2014. 3.
- 13. Han, Wei*; Wu, Yiran#; Zeng, Liting; Zhao, Suwen.Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR.SCIENCE CHINA LIFE SCIENCES. 01 Jun 2022.
- 14. Wu, Meng*; Sun, Liping; Zhou, Qingtong; Peng, Yao; Liu, Zhijie; Zhao, Suwen#.Molecular Mechanism of Acetate Transport through the Acetate Channel SatP.JOURNAL OF CHEMICAL INFORMATION AND MODELING. May 2019. 59(5):2374-2382.
- 15. Liu, Dazhi*; Wei, Yifeng; Liu, Xuyang; Zhou, Yan; Jiang, Li; Yin, Jinyu; Wang, Feifei; Hu, Yiling; Urs, Ankanahalli N. Nanjaraj; Liu, Yanhong; Ang, Ee Lui; Zhao, Suwen#; Zhao, Huimin#; Zhang, Yan#.Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.NATURE COMMUNICATIONS. 11 Oct 2018. 9.
- 16. Ye, Lintao*; Ding, Kang; Zhao, Fei; Liu, Xiaoyan; Wu, Yiran; Liu, Yang; Xue, Dongxiang; Zhou, Fang; Zhang, Xianjun; Stevens, Raymond C.; Xu, Fei; Zhao, Suwen#; Tao, Houchao#.A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.MEDCHEMCOMM. Jun 2017. 8(6):1332-1336.
- 17. Jacobson, Matthew P.#*; Kalyanaraman, Chakrapani; Zhao, Suwen; Tian, Boxue.Leveraging structure for enzyme function prediction: methods, opportunities, and challenges.TRENDS IN BIOCHEMICAL SCIENCES. 2014. 39(8):363-371.
- 18. Kumar, Ritesh*; Zhao, Suwen; Vetting, Matthew W.; Wood, B. McKay; Sakai, Ayano; Cho, Kyuil; Solbiati, Jose; Almo, Steven C.; Sweedler, Jonathan V.; Jacobson, Matthew P.; Gerlt, John A.#; Cronan, John E.#.Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine.MBIO. 2014. 5(1).
- 19. Zhao, Suwen*; Zhu, Kai; Li, Jianing; Friesner, Richard A.#.Progress in super long loop prediction.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2011. 79(10):2920-2935.
- 20. Xue, Dongxiang*; Xu, Tiandan; Wang, Huixia; Wu, Meng; Yuan, Ya; Wang, Wei; Tan, Qiwen; Zhao, Fei; Zhou, Fang; Hu, Tao; Jiang, Zhongxing; Liu, Zhi-Jie; Zhao, Suwen; Liu, Dongsheng; Wuthrich, Kurt#; Tao, Houchao#.Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.CHEMISTRY-A EUROPEAN JOURNAL. 13 Aug 2019.
- 21. Zhou, Qingtong*; Sun, Xianbao; Xia, Xiaole; Fan, Zhou; Luo, Zhaofeng; Zhao, Suwen; Shakhnovich, Eugene#; Liang, Haojun#.Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space.JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 19 Jan 2017. 8(2):407-414.
- 22. Hua, Tian*; Vemuri, Kiran; Pu, Mengchen; Qu, Lu; Han, Gye Won; Wu, Yiran; Zhao, Suwen; Shui, Wenqing; Li, Shanshan; Korde, Anisha; Laprairie, Robert B.; Stahl, Edward L.; Ho, Jo-Hao; Zvonok, Nikolai; Zhou, Han; Kufareva, Irina; Wu, Beili; Zhao, Qiang; Hanson, Michael A.; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal Structure of the Human Cannabinoid Receptor CB1.CELL. 2016. 167(3):750-762.
- 23. Li, Zhenjian*; Tang, Yannan; Wu, Yiran; Zhao, Suwen; Bao, Juan; Luo, Yitian; Li, Dianfan#.Structural insights into the committed step of bacterial phospholipid biosynthesis.NATURE COMMUNICATIONS. 22 Nov 2017. 8.
- 24. Song, Gaojie*; Yang, Dehua; Wang, Yuxia; de Graaf, Chris; Zhou, Qingtong; Jiang, Shanshan; Liu, Kaiwen; Cai, Xiaoqing; Dai, Antao; Lin, Guangyao; Liu, Dongsheng; Wu, Fan; Wu, Yiran; Zhao, Suwen; Ye, Li; Han, Gye Won; Lau, Jesper; Wu, Beili; Hanson, Michael A.; Liu, Zhi-Jie#; Wang, Ming-Wei#; Stevens, Raymond C.#.Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.NATURE. 08 Jun 2017. 546(7657):312-+.
- 25. Ma, Yingli*; Yue, Yang; Ma, Yanbin; Zhang, Qing; Zhou, Qingtong; Song, Yunpeng; Shen, Yuqing; Li, Xun; Ma, Xiaochuan; Li, Chao; Hanson, Michael A.; Han, Gye Won; Sickmier, E. Allen; Swaminath, Gayathri; Zhao, Suwen; Stevens, Raymond C.; Hu, Liaoyuan A.; Zhong, Wenge; Zhang, Mingqiang; Xu, Fei#.Structural Basis for Apelin Control of the Human Apelin Receptor.STRUCTURE. 06 Jun 2017. 25(6):858-+.
- 26. Zhang, Ruijie*; Xu, Xuexia; Cao, Huijin; Yuan, Chenyang; Yuminaga, Yuki; Zhao, Suwen; Shi, Jiping#; Zhang, Baoguo#.Purification, characterization, and application of a high activity 3-ketosteroid-Delta(1)-dehydrogenase from Mycobacterium neoaurum DSM 1381.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. Aug 2019. 103(16):6605-6616.
- 27. Xue, Dongxiang*; Ye, Lintao; Zheng, Jun; Wu, Yiran; Zhang, Xianjun; Xu, Yueming; Li, Tao; Stevens, Raymond C.; Xu, Fei; Zhuang, Min; Zhao, Suwen; Zhao, Fei#; Tao, Houchao#.The structure-based traceless specific fluorescence labeling of the smoothened receptor.ORGANIC & BIOMOLECULAR CHEMISTRY. 07 Jul 2019. 17(25):6136-6142.
- 28. Wang, Yi Shuang*; Zhang, Bo; Zhu, Jiapeng#; Yang, Cheng Long; Guo, Yu; Liu, Cheng Li; Liu, Fang; Huang, Huiqin; Zhao, Suwen; Liang, Yong; Jiao, Rui Hua; Tan, Ren Xiang#; Ge, Hui Ming#.Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 29 Aug 2018. 140(34):10909-10914.
- 29. Liu Xuyang*, Gao Zhan-Guo, Wu Yiran, Stevens Raymond C., Jacobson Kenneth A., Zhao Suwen.Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018).SCIENTIFIC REPORTS. 24 Jul 2018. 8.
- 30. Ai, Huasong*; Guo, Yu; Sun, Demeng; Liu, Sanling; Qi, Yunkun; Guo, Jing; Qu, Qian; Gong, Qingyue; Zhao, Suwen#; Li, Jiabin#; Liu, Lei#.Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones.CHEMBIOCHEM. 18 Jan 2019. 20(2):221-229.
- 31. Li, Xiaoting*; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R.; Cinar, Resat; Coffey, Nathan J.; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal Structure of the Human Cannabinoid Receptor CB2.CELL. 24 Jan 2019. 176(3):459-+.
- 32. Peng, Yao*; McCorvy, John D.; Harpsoe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-Ping; Wu, Yiran; Shen, Ling; Bjorn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.#; Stevens, Raymond C.#; Liu, Zhi-Jie#.5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.CELL. 08 Feb 2018. 172(4):719-+.
- 33. Shang, Wanjing*; Jiang, Yong*; Boettcher, Michael; Ding, Kang; Mollenauer, Marianne; Liu, Zhongyi; Wen, Xiaofeng; Liu, Chang; Hao, Piliang; Zhao, Suwen; McManus, Michael T.; Wei, Lai#; Weiss, Arthur#; Wang, Haopeng#.Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 24 Apr 2018. 115(17):E4051-E4060.
- 34. Zhang, Xianjun*; Zhao, Fei; Wu, Yiran; Yang, Jun; Han, Gye Won; Zhao, Suwen; Ishchenko, Andrii; Ye, Lintao; Lin, Xi; Ding, Kang; Dharmarajan, Venkatasubramanian; Griffin, Patrick R.; Gati, Cornelius; Nelson, Garrett; Hunter, Mark S.; Hanson, Michael A.; Cherezov, Vadim; Stevens, Raymond C.; Tan, Wenfu#; Tao, Houchao#; Xu, Fei#.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.NATURE COMMUNICATIONS. 17 May 2017. 8(1).
- 35. Yang, Shifan*; Wu, Yiran; Xu, Ting-Hai; de Waal, Parker W.; He, Yuanzheng; Pu, Mengchen; Chen, Yuxiang; DeBruine, Zachary J.; Zhang, Bingjie; Zaidi, Saheem A.; Popov, Petr; Guo, Yu; Han, Gye Won; Lu, Yang; Suino-Powell, Kelly; Dong, Shaowei; Harikumar, Kaleeckal G.; Miller, Laurence J.; Katritch, Vsevolod; Xu, H. Eric; Shui, Wenqing; Stevens, Raymond C.; Melcher, Karsten; Zhao, Suwen; Xu, Fei#.Crystal structure of the Frizzled 4 receptor in a ligand-free state.NATURE. 2018. 560(7720):666-670.
- 36. Qin, Shanshan*; Meng, Mengmeng; Yang, Dehua; Bai, Wenwen; Lu, Yan; Peng, Yao; Song, Gaojie; Wu, Yiran; Zhou, Qingtong; Zhao, Suwen; Huang, Xiping; McCorvy, John D.; Cai, Xiaoqing; Dai, Antao; Roth, Bryan L.; Hanson, Michael A.; Liu, Zhi-Jie; Wang, Ming-Wei#; Stevens, Raymond C.; Shui, Wenqing#.High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.CHEMICAL SCIENCE. 2018. 9(12):3192-3199.
- 37. Qiu, Biao*; Xia, Bingqing; Zhou, Qingtong; Lu, Yan; He, Miaomiao; Hasegawa, Kazuya; Ma, Zhiqiang; Zhang, Fengyu; Gu, Lichuan; Mao, Qionglei; Wang, Feng; Zhao, Suwen; Gao, Zhaobing#; Liao, Jun#.Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate.CELL RESEARCH. Jun 2018. 28(6):644-654.
- 38. Zhang, Shanshan*; Ding, Kang; Shen, Qing-Ji; Zhao, Suwen; Liu, Ji-Long#.Filamentation of asparagine synthetase in Saccharomyces cerevisiae.PLOS GENETICS. Oct 2018. 14(10).
- 39. Yang, Longjin*; Tae, Han-Shen; Fan, Zhou; Shao, Xiaoxia; Xu, Shaoqiong; Zhao, Suwen; Adams, David J.#; Wang, Chunguang#.A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from D-Conotoxin GeXXA.MARINE DRUGS. Jun 2017. 15(6).
- 40. Peng Yao*; Zhao Simeng; Wu Yiran; Cao Haijie; Xu Yueming; Liu Xiaoyan; Shui Wenqing; Cheng Jianjun; Zhao Suwen; Shen Ling; Ma Jun; Quinn Ronald J; Raymond C. Stevens; Zhong Guisheng#; Liu Zhijie#.Identification of natural products as novel ligands for the human 5-HT_(2C) receptor.BIOPHYSICSREPORTS. 2018. 4(1):50-61.
- 41. Zhou, F.*; Ding, K.; Zhou, Y.; Liu, Y.; Liu, X.; Zhao, F.; Wu, Y.; Zhang, X.; Xu, F.; Zhao, S.; Tao, H..Determination of an underneath binding in the transmembrane domain of smoothened receptor.JOURNAL OF BIOENERGETICS AND BIOMEMBRANES. Dec 2018. 50(6):510-510.
- 42. Sun, Weiping*; Huo, Yinbo; Mei, Yuxuan; Zhou, Qingtong; Zhao, Suwen; Zhuang, Min#.Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling.ACS CHEMICAL BIOLOGY. Jan 2020. 15(1):39-43.
- 43. Xia, Lisha*; Ma, Ziliang; Tong, Jiahui; Tang, Yuliang; Li, Shanshan; Qin, Shanshan; Lou, Ronghui; Zhao, Suwen; Lei, Xiaoguang#; Shui, Wenqing#.Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry.ANALYTICA CHIMICA ACTA. 15 Mar 2020. 1102:53-62.
- 44. Hua, Tian#*; Li, Xiaoting; Wu, Lijie; Iliopoulos-Tsoutsouvas, Christos; Wang, Yuxia; Wu, Meng; Shen, Ling; Johnston, Christina A.; Nikas, Spyros P.; Song, Feng; Song, Xiyong; Yuan, Shuguang; Sun, Qianqian; Wu, Yiran; Jiang, Shan; Grim, Travis W.; Benchama, Othman; Stahl, Edward L.; Zvonok, Nikolai; Zhao, Suwen; Bohn, Laura M.; Makriyannis, Alexandros; Liu, Zhi-Jie#.Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G(i) Complex Structures.CELL. 20 Feb 2020. 180(4):655-+.
- 45. Lin, Xi*; Li, Mingyue*; Wang, Niandong*; Wu, Yiran*; Luo, Zhipu; Guo, Shimeng; Han, Gye-Won; Li, Shaobai; Yue, Yang; Wei, Xiaohu; Xie, Xin; Chen, Yong; Zhao, Suwen; Wu, Jian#; Lei, Ming#; Xu, Fei#.Structural basis of ligand recognition and self-activation of orphan GPR52.NATURE. 19 Feb 2020.
- 46. Lu, Lining*; Guo, Yu; Wang, Tian; Liang, Lujun; Zhao, Suwen#; Wang, Feng#; Liu, Lei#.Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop.SCIENCE CHINA-CHEMISTRY. Feb 2020. 63(2):237-243.
- 47. Zhang, Ya*; Zhang, Hongyuan; Wang, Zhipeng; Wu, Zhaowei; Wang, Yu; Tang, Na; Xu, Xuexia; Zhao, Suwen; Chen, Weizhong#; Ji, Quanjiang#.Programmable adenine deamination in bacteria using a Cas9-adenine-deaminase fusion.CHEMICAL SCIENCE. 14 Feb 2020. 11(6):1657-1664.
- 48. Sun, Huiyan*; Zhou, Yi; Skaro, Michael Francis; Wu, Yiran; Qu, Zexing; Mao, Fenglou; Zhao, Suwen; Xu, Ying#.Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production.CANCER RESEARCH. Mar 2020. 80(5):1143-1155.
- 49. Zhang, Bingjie*; Zhao, Simeng; Yang, Dehua; Wu, Yiran; Xin, Ye; Cao, Haijie; Huang, Xi-Ping; Cai, Xiaoqing; Sun, Wen; Ye, Na; Xu, Yueming; Peng, Yao; Zhao, Suwen; Liu, Zhi-Jie; Zhong, Guisheng#; Wang, Ming-Wei#; Shui, Wenqing#.A novel G protein-biased and subtype-selective agonist for a G protein-coupled receptor discovered from screening herbal extracts.ACS CENTRAL SCIENCE. 2020. 6(2):213-225.
- 50. Wang, Jingjing*; Wu, Meng; Wu, Lijie; Xu, Yueming; Li, Fei; Wu, Yiran; Popov, Petr; Wang, Lin; Bai, Fang; Zhao, Suwen; Liu, Zhi-Jie; Hua, Tian#.The structural study of mutation-induced inactivation of human muscarinic receptor M4.IUCRJ. Mar 2020. 7:294-305.
- 51. Yu, Jing*; Gimenez, Luis E.; Hernandez, Ciria C.; Wu, Yiran; Wein, Ariel H.; Han, Gye Won; McClary, Kyle; Mittal, Sanraj R.; Burdsall, Kylie; Stauch, Benjamin; Wu, Lijie; Stevens, Sophia N.; Peisley, Alys; Williams, Savannah Y.; Chen, Valerie; Millhauser, Glenn L.; Zhao, Suwen; Cone, Roger D.#; Stevens, Raymond C.#.Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.SCIENCE. 24 Apr 2020. 368(6489):428-+.
- 52. Zhang, Bo*; Tastan, Omur Y.*; Zhou, Xian*; Guo, Chen-Jun; Liu, Xuyang; Thind, Aaron; Hu, Huan-Huan; Zhao, Suwen; Liu, Ji-Long#.The proline synthesis enzyme P5CS forms cytoophidia in Drosophila.JOURNAL OF GENETICS AND GENOMICS. 20 Mar 2020. 47(3):131-143.
- 53. Tan, Liang*; Zhou, Qingtong; Yan, Wenzhong; Sun, Jian; Kozikowski, Alan P.; Zhao, Suwen; Huang, Xi-Ping#; Cheng, Jianjun#.Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.JOURNAL OF MEDICINAL CHEMISTRY. 14 May 2020. 63(9):4579-4602.
- 54. Pu, Jiahua*; Liu, Yi*; Zhang, Jicong; An, Bolin; Li, Yingfeng; Wang, Xinyu; Din, Kang; Qin, Chong; Li, Ke; Cui, Mengkui; Liu, Suying; Huang, Yuanyuan; Wang, Yanyi; Lv, Yanan; Huang, Jiaofang; Cui, Zongqiang; Zhao, Suwen; Zhong, Chao#.Virus Disinfection from Environmental Water Sources Using Living Engineered Biofilm Materials.ADVANCED SCIENCE. 22 May 2020.
- 55. Tong, Bin#*; Wang, Jiapeng; Cheng, Zixuan; Liu, Jiasen; Wu, Yiran; Li, Yunhua; Bai, Chunling; Zhao, Suwen; Yu, Haiquan; Li, Guangpeng.Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep.GENES. Apr 2020. 11(4).
- 56. Liu, Kaiwen*; Wu, Lijie; Yuan, Shuguang; Wu, Meng; Xu, Yueming; Sun, Qianqian; Li, Shu; Zhao, Suwen; Hua, Tian#; Liu, Zhi-Jie#.Structural basis of CXC chemokine receptor 2 activation and signalling.NATURE. Jul 2020.
- 57. Zhou, Fulai*; Zhang, Huibing; Cong, Zhaotong; Zhao, Li-Hua; Zhou, Qingtong; Mao, Chunyou; Cheng, Xi; Shen, Dan-Dan; Cai, Xiaoqing; Ma, Cheng; Wang, Yuzhe; Dai, Antao; Zhou, Yan; Sun, Wen; Zhao, Fenghui; Zhao, Suwen; Jiang, Hualiang; Jiang, Yi; Yang, Dehua#; Xu, H. Eric#; Zhang, Yan#; Wang, Ming-Wei#.Structural basis for activation of the growth hormone-releasing hormone receptor.NATURE COMMUNICATIONS. 15 Oct 2020. 11(1).
- 58. Sun, Wen*; Chen, Li-Nan; Zhou, Qingtong; Zhao, Li-Hua; Yang, Dehua; Zhang, Huibing; Cong, Zhaotong; Shen, Dan-Dan; Zhao, Fenghui; Zhou, Fulai; Cai, Xiaoqing; Chen, Yan; Zhou, Yan; Gadgaard, Sarina; van der Velden, Wijnand J. C.; Zhao, Suwen; Jiang, Yi; Rosenkilde, Mette M.; Xu, H. Eric#; Zhang, Yan#; Wang, Ming-Wei#.A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.CELL RESEARCH. 25 Nov 2020.
- 59. Ma, Mengna#*; Guo, Shimeng; Lin, Xi; Li, Shanshan; Wu, Yiran; Zeng, Yanping; Hu, Youhong; Zhao, Suwen; Xu, Fei; Xie, Xin; Shui, Wenqing.Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52.ACS CHEMICAL BIOLOGY. 18 Dec 2020. 15(12):3275-3284.
- 60. Yang, Dehua*; Zhou, Qingtong; Labroska, Viktorija; Qin, Shanshan; Darbalaei, Sanaz; Wu, Yiran; Yuliantie, Elita; Xie, Linshan; Tao, Houchao; Cheng, Jianjun; Liu, Qing; Zhao, Suwen; Shui, Wenqing#; Jiang, Yi#; Wang, Ming-Wei#.G protein-coupled receptors: structure- and function-based drug discovery.SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2021. 6(1):7.
- 61. Martin, Charlotte*; Gimenez, Luis E.; Williams, Savannah Y.; Jing, Yu; Wu, Yiran; Hollanders, Charlie; Van der Poorten, Olivier; Gonzalez, Simon; Van Holsbeeck, Kevin; Previti, Santo; Lamouroux, Arthur; Zhao, Suwen; Tourwe, Dirk; Stevens, Raymond C.; Cone, Roger D.; Ballet, Steven.Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure.JOURNAL OF MEDICINAL CHEMISTRY. Jan 2021. 64(1):357-369.
- 62. Yang, Dehua*; Zhou, Qingtong; Labroska, Viktorija; Qin, Shanshan; Darbalaei, Sanaz; Wu, Yiran; Yuliantie, Elita; Xie, Linshan; Tao, Houchao; Cheng, Jianjun; Liu, Qing; Zhao, Suwen; Shui, Wenqing#; Jiang, Yi#; Wang, Ming-Wei#.G protein-coupled receptors: structure- and function-based drug discovery.SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2021. 6(1).
- 63. Tong, Jiahui*; Zhao, Suwen.Large-Scale Analysis of Bioactive Ligand Conformational Strain Energy by Ab Initio Calculation.JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2021. 61(3):1180-1192.
- 64. Xie, Guoxiang*; Jiang, Runqiu; Wang, Xiaoning; Liu, Ping; Zhao, Aihua; Wu, Yiran; Huang, Fengjie; Liu, Zhipeng; Rajani, Cynthia; Zheng, Xiaojiao; Qiu, Jiannan; Zhang, Xiaoling; Zhao, Suwen; Bian, Hua; Gao, Xin; Sun, Beicheng; Jia, Wei.Conjugated secondary 12 alpha-hydroxylated bile acids promote liver fibrogenesis.EBIOMEDICINE. 2021. 66.
- 65. Lu, Yan*; Liu, Hongyue; Yang, Dehua; Zhong, Li; Xin, Ye; Zhao, Suwen; Wang, Ming-Wei#; Zhou, Qingtong#; Shui, Wenqing#.Affinity mass spectrometry-based fragment screening identified a new negative allosteric modulator of the adenosine A 2A receptor targeting the sodium ion pocket.ACS CHEMICAL BIOLOGY. 2021. 16(6):991-1002.
- 66. Xu, Luyan*; Tong, Jiahui; Wu, Yiran; Zhao, Suwen; Li, Bo-Lin.A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues.BIOPHYSICAL CHEMISTRY. 2021. 276.
- 67. Lu, Yan*; Liu, Hongyue; Yang, Dehua; Zhong, Li; Xin, Ye; Zhao, Suwen; Wang, Ming-Wei; Zhou, Qingtong; Shui, Wenqing.Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket.ACS CHEMICAL BIOLOGY. 2021. 16(6):991-1002.
- 68. Zhou, Qingtong*; Guo, Wanjing; Dai, Antao; Cai, Xiaoqing; Vass, Marton; de Graaf, Chris; Shui, Wenqing; Zhao, Suwen; Yang, Dehua; Wang, Ming-Wei.Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening.BIOMOLECULES. 01 Jul 2021. 11(7).
- 69. Wu, Yiran*; Zeng, Liting; Zhao, Suwen.Ligands of Adrenergic Receptors: A Structural Point of View.BIOMOLECULES. 01 Jul 2021. 11(7).
- 70. Xia, Lisha*; Ma, Ziliang; Tong, Jiahui; Tang, Yuliang; Li, Shanshan; Qin, Shanshan; Lou, Ronghui; Zhao, Suwen; Lei, Xiaoguang; Shui, Wenqing.Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry (vol 1102, pg 53, 2020).ANALYTICA CHIMICA ACTA. 2021. 1165.
- 71. 周庆同*; 戴之卓; 赵素文#.G蛋白偶联受体的共同激活机制.自然杂志. 2021.
- 72. Zhang, Xuefeng*; He, Chenglin; Wang, Mu; Zhou, Qingtong; Yang, Dehua; Zhu, Ya; Feng, Wenbo; Zhang, Hui; Dai, Antao; Chu, Xiaojing; Wang, Jia; Yang, Zhenlin; Jiang, Yi; Sensfuss, Ulrich; Tan, Qiuxiang; Han, Shuo; Reedtz-Runge, Steffen; Xu, H. Eric; Zhao, Suwen; Wang, Ming-Wei; Wu, Beili; Zhao, Qiang.Structures of the human cholecystokinin receptors bound to agonists and antagonists.NATURE CHEMICAL BIOLOGY. 2021.
- 73. Zhao, Fei*; Wu, Yiran; Zhou, Fang; Xue, Dongxiang; Zhao, Simeng; Lu, Wanglong; Liu, Xiaoyan; Hu, Tao; Qiu, Yanli; Li, Rongyan; Gu, Tangjie; Xu, Yueming; Xu, Fei; Zhong, Guisheng; Jiang, Zhongxing; Zhao, Suwen; Tao, Houchao.Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.JOURNAL OF MEDICINAL CHEMISTRY. 2021. 64(18):13830-13840.
- 74. Hu, Tao*; Zheng, Guoxun; Xue, Dongxiang; Zhao, Simeng; Li, Fei; Zhou, Fang; Zhao, Fei; Xie, Linshan; Tian, Cuiping; Hua, Tian; Zhao, Suwen; Xu, Yueming; Zhong, Guisheng; Liu, Zhi-Jie; Makriyannis, Alexandros; Stevens, Raymond C.; Tao, Houchao.Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools.JOURNAL OF MEDICINAL CHEMISTRY. 2021. 64(18):13752-13765.
- 75. Wu, Yiran*; Zhao, Suwen.Furin cleavage sites naturally occur in coronaviruses.STEM CELL RESEARCH. Jan 2021. 50:#VALUE!.
- 76. Ma, Mengna*; Guo, Shimeng; Lin, Xi; Li, Shanshan; Wu, Yiran; Zeng, Yanping; Hu, Youhong; Zhao, Suwen; Xu, Fei; Xie, Xin; Shui, Wenqing#.Targeted proteomics combined with affinity mass spectrometry analysis reveals antagonist E7 acts as an intracellular covalent ligand of orphan receptor GPR52.ACS CHEMICAL BIOLOGY. 2020. 15(12):3275-3284.
- 77. Liu, Yang*; Zhou, Fang; Ding, Kang; Xue, Dongxiang; Zhu, Zhihao; Li, Cuixia; Li, Fei; Xu, Yueming; Xu, Fei; Le, Zhiping; Zhao, Suwen; Tao, Houchao.Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor.CHEMISTRYOPEN. 2021. 10(10):1028-1032.
- 78. Yan, Wenzhong*; Ling, Lijun; Wu, Yiran; Yang, Kexin; Liu, Ruiquan; Zhang, Jinfeng; Zhao, Simeng; Zhong, Guisheng; Zhao, Suwen; Jiang, Hualiang#; Xie, Chengying#; Cheng, Jianjun#.Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A(2A) Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents.JOURNAL OF MEDICINAL CHEMISTRY. 25 Nov 2021. 64(22).
- 79. Ma, Shujiao*; Ji, Xuewen; Cang, Ming; Wang, Jianguo; Yu, Haiquan; Liu, Yongbin; Zhang, Wenguang; Wu, Yiran; Zhao, Suwen; Cao, Guifang; Tong, Bin.Association analysis between novel variants in LEPR gene and litter size in Mongolia and ujimqin sheep breeds.THERIOGENOLOGY. 15 Apr 2022. 183:79-89.
- 80. Wu, Yiran*; Li, Xuanxuan; Hua, Tian; Liu, Zhi-Jie; Liu, Haiguang#; Zhao, Suwen#.MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1.FRONTIERS IN MOLECULAR BIOSCIENCES. 29 Mar 2022. 9.
- 81. Liu, Yinbo*; Wei, Yifeng; Teh, Tong Mei; Liu, Dazhi; Zhou, Yan; Zhao, Suwen; Ang, Ee Lui; Zhao, Huimin#; Zhang, Yan#.Identification and Characterization of the Biosynthetic Pathway of the Sulfonolipid Capnine.BIOCHEMISTRY. 2022.
- 82. Cui, Min*; Zhou, Qingtong#; Xu, Yueming; Weng, Yuan; Yao, Deqiang; Zhao, Suwen; Song, Gaojie#.Crystal structure of a constitutive active mutant of adenosine A(2A) receptor.IUCRJ. 01 May 2022. 9.
- 83. Yang, Meifang*; Luo, Weiling*; Zhang, Wei*; Wang, Huixia; Xue, Dongxiang; Wu, Yiran; Zhao, Suwen; Zhao, Fei#; Zheng, Xing#; Tao, Houchao#.Ugi Reaction Mediated Detergent Assembly for Membrane Protein Studies.CHEMISTRY-AN ASIAN JOURNAL. 01 Jun 2022.
- 84. Ai, Huasong*; Sun, Maoshen; Liu, Aijun; Sun, Zixian; Liu, Tingting; Cao, Lin; Liang, Lujun; Qu, Qian; Li, Zichen; Deng, Zhiheng; Tong, Zebin; Chu, Guochao; Tian, Xiaolin; Deng, Haiteng; Zhao, Suwen; Li, Jia-Bin#; Lou, Zhiyong#; Liu, Lei#.H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.NATURE CHEMICAL BIOLOGY. 01 Jun 2022.
- 85. Dou, Wei-Tao*; Wang, Xiang; Liu, Tingting; Zhao, Suwen; Liu, Jiao-Jiao; Yan, Yao; Li, Jun; Zhang, Chi-Yu; Sedgwick, Adam C.; Tian, He; Sessler, Jonathan L.#; Zhou, Dong-Ming#; He, Xiao-Peng#.A homogeneous high-throughput array for the detection and discrimination of influenza A viruses.CHEM. 09 Jun 2022. 8(6).
- 86. Zhang,Yifei*; Zhang,Hongyuan; Xu,Xuexia; Wang,yujue; Chen,Weizhong; Wang,Yannan; Wu,Zhaowei; Tang,Na; Wang,Yu; Zhao,Suwen; Gan,Jianhua#; Ji,Quanjiang#.Catalytic-state structure and engineering of Streptococcus thermophilus Cas9.NATURE CATALYSIS. Sep 2020. 3(10):813-+.
- 87. Wang, Jingjing*; Wu, Meng; Chen, Zhangcheng; Wu, Lijie; Wang, Tian; Cao, Dongmei; Wang, Huan; Liu, Shenhui; Xu, Yueming; Li, Fei; Liu, Junlin; Chen, Na; Zhao, Suwen; Cheng, Jianjun; Wang, Sheng; Hua, Tian.The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.NATURE COMMUNICATIONS. 01 Dec 2022. 13(1).
专著
GPCR Allosteric Modulator Discovery. Wu, Yiran; Tong, Jiahui; Ding, Kang; Zhou, Qingtong; Zhao, Suwen. Book Chapter in Protein Allostery in Drug Discovery, Advances in Experimental Medicine and Biology. 1163:225-251
奖励
- 1. 2016年，浦江人才
- 2. 2017年，上海市青年拔尖人才
课题组成员及合影
-
姓名：吴屹然
身份：助理研究员
在组时间：2014/06-至今
邮箱：wuyr@@shanghaitech.edu.cn
-
姓名：李文婧
身份：助理研究员
在组时间：2021.06-至今
邮箱：liwj@shanghaitech.edu.cn
-
姓名：韩伟
身份：博士后
在组时间：2016/11-至今
邮箱：hanwei@@shanghaitech.edu.cn
-
姓名：樊满琳
身份：博士研究生
在组时间：2018/03-至今
邮箱：fanml@@shanghaitech.edu.cn
-
姓名：林菁
身份：博士研究生
在组时间：2018/09-至今
邮箱：linjing@@shanghaitech.edu.cn
-
姓名：吴欣颖
身份：博士研究生
在组时间：2020/01-至今
邮箱：WUxy2@@shanghaitech.edu.cn
-
姓名：成语
身份：助理工程师
在组时间：2019/09-至今
邮箱：chengyu@@shanghaitech.edu.cn
-
姓名：曾丽婷
身份：博士研究生
在组时间：2021.1-至今
邮箱：zenglt@shanghaitech.edu.cn
-
姓名：杨书逸
身份：硕士研究生
在组时间：2021.1-至今
邮箱：yangsy@shanghaitech.edu.cn
-
姓名：陈荟玉
身份：硕士研究生
在组时间：2022.1-至今
邮箱：chenghy@shanhaitech.edu.cn
-
姓名：禹柯鑫
身份：硕士研究生
在组时间：2022.1-至今
邮箱：yukx@shanghaitech.edu.cn
-
姓名：王文通
身份：硕士研究生
在组时间：2022.1-至今
邮箱：wangwt@shanghaitech.edu.cn
-
姓名：贾宇
身份：硕士研究生
在组时间：2022.1-至今
邮箱：jiayu@shanghaitech.edu.cn
|
