课题组长
姓名：
朱学良中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
课题组简介
研究内容：
运动是细胞的基本行为之一。细胞的各种运动形式，如分裂、迁移、纤毛运动、胞内运输等以其重要、复杂、动态和完美展现出强烈的吸引力。我们利用分子生物学、细胞生物学和发育生物学的各种技术和手段研究细胞运动的结构基础、调节机理，及其与干细胞自我更新、分化和疾病的关系。其中涉及细胞骨架、分子马达、中心粒、动粒等细胞结构和组分，以及物质运输、信号转导、基因表达、蛋白质修饰和相互作用等过程。这些丰富的研究内容既充满挑战又富于情趣。每位热爱生命科学研究的学子都可以从中找到属于自己的乐土。
代表性论文（*第一作者，#通讯作者）
- 1. Cao, Jingli*; Shen, Yidong; Zhu, Lei; Xu, Yanan; Zhou, Yizhuo; Wu, Zhili; Li, Yiping; Yan, Xiumin#; Zhu, Xueliang#; .miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.NATURE CELL BIOLOGY. 2012. 14(7):697-76.
- 2. Xu, Yanan*; Cao, Jingli; Huang, Shan; Feng, Di; Zhang, Wei; Zhu, Xueliang#; Yan, Xiumin; .Characterization of Tetratricopeptide Repeat-Containing Proteins Critical for Cilia Formation and Function.PLOS ONE. 10 Apr 2015. 10(4).
- 3. Zhao, Huijie#*; Chen, Qingxia; Fang, Chuyu; Huang, Qiongping; Zhou, Xueliang; Yan, Xiumin#; Zhu, Xueliang#; .Parental centrioles are dispensable for deuterosome formation and function during basal body amplification.EMBO REPORTS. 04 Mar 2020. 20(4).
- 4. Shan, Yongli#*; Yu, Lihou; Li, Yan; Pan, Youdong; Zhang, Qiangge; Wang, Fubin; Chen, Jianfeng; Zhu, Xueliang#; .Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin.PLOS BIOLOGY. 2009. 7(5).
- 5. Ma, Li*; Tsai, Ming-Ying; Wang, Shusheng; Lu, Bingwen; Chen, Rong; Yates, John R., III; Zhu, Xueliang#; Zheng, Yixian#; .Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.NATURE CELL BIOLOGY. 2009. 11(3):246.
- 6. Shen, Yidong*; Li, Ning; Wu, Shuang; Zhou, Yizhuo; Shan, Yongli; Zhang, Qiangge; Ding, Chong; Yuan, Quan; Zhao, Fukun; Zeng, Rong; Zhu, Xueliang#; .Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.DEVELOPMENTAL CELL. 2008. 14(3):342-353.
- 7. Zeng, Liyong*; Cai, Cheguo; Li, Shan; Wang, Wenjuan; Li, Yaping; Chen, Jiangye; Zhu, Xueliang#; Zeng, Yi Arial#; .Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.PLOS GENETICS. May 2016. 12(5).
- 8. Zhang, Qiangge*; Wang, Fubin; Cao, Jingli; Shen, Yidong; Huang, Qiongping; Bao, Lan; Zhu, Xueliang#; .Nudel Promotes Axonal Lysosome Clearance and Endo-lysosome Formation via Dynein-Mediated Transport.TRAFFIC. 2009. 10(9):1337-1349.
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