Principal investigator
Name:
Yifeng ZhangAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Sports Medicine
Research Interests:
Dr Zhang’s research group is focused on basic research of Muscular-skeletal diseases, and developing novel biomaterials to promote fracture healing, osteoarthritis treatment, and tendon-bone joint interface repairing. To solve the main illnesses in Sports Medicine such as : Osteoporosis, Osteonecrosis, Tendon-bone destruction, Non-healing bone fracture, Neuromuscular diseases, we aim to explore the mechanism of these musculoskeletal diseases, and develop the biomaterials, medical apparatus and therapeutic drugs for patients.
Dr ZHANG and his collaborators firstly illustrate the mechanism of magnesium metal’s intramembrane ossification effect in vivo, and designed a novel magnesium ion releasing intramedullary needle for promoting osteoporotic fracture healing. Then after, Dr ZHANG’s group developed 3 kinds of multi-layers coating on magnesium metal surface to control magnesium degradation in vivo. That makes the direct usage of metal magnesium in fracture fixation to be possible. Meanwhile, the group focused on the cell transdifferentiation in endochondro-ossification process. Controlling fracture healing by affecting cell plasticity are studied in NAMPT and Mg ions project. Based on Mg ions’ inhibiting effect on stem cell senescence, and its effect on keeping stem cell pluri-potency, our group are designing Mg ion control-releasing nanoparticles to treat osteoarthritis, and magnesium interface screws to fix and heal tendon-bone interface damage.
Including:
1.The mechanism of acquiring cell plasticity and asymmetric division of chondrocytes in transdifferentiating to osteoblasts.
2.The healing mechanism of repairing tendon-bone tearing by maintaining stem cell pluripotency in tendon-bone interface.
3.Designing and developing of biodegradable magnesium implants /or cell sheet to fixing and repairing cruciate ligaments and rotator cuff damage.
4.Designing and developing of biodegradable magnesium implants to fixing bone fracture.
5.Novel drug control-releasing materials in osteoarthritis treatment (Mg ions/ Cerium Oxide/ FK866 control-releasing PLGA nanoparticles).
Representative Publications (*First Author, # Corresponding Author)
- 1. Li, Yixuan*; Zhao, Sheng; Li, Sirong; Ge, Yuxiang; Wang, Rongliang; Zheng, Liming; Xu, Jiankun; Sun, Minghui; Jiang, Qing#; Zhang, Yifeng#; Wei, Hui#.Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.SMALL. 22 Nov 2019.
- 2. Yao, H.*; Xu, J. K.; Zheng, N. Y.; Wang, J. L.; Mok, S. W.; Lee, Y. W.; Shi, L.; Wang, J. Y.; Yue, J.; Yung, S. H.; Hu, P. J.; Ruan, Y. C.; Zhang, Yifeng; Ho, K. W.#; Qin, L.#.Intra-articular injection of magnesium chloride attenuates osteoarthritis progression in rats.OSTEOARTHRITIS AND CARTILAGE. Dec 2019. 27(12):1811-1821.
- 3. Zhang, Yifeng*; Xu, Jiankun; Ruan, Ye Chun; Yu, Mei Kuen; O'Laughlin, Micheal; Wise, Helen; Chen, Di; Tian, Li; Shi, Dufang; Wang, Jiali; Chen, Sihui; Feng, Jian Q.; Chow, Dick Ho Kiu; Xie, Xinhui; Zheng, Lizhen; Huang, Le; Huang, Shuo; Leung, Kwoksui; Lu, Na; Zhao, Lan; Li, Huafang; Zhao, Dewei; Guo, Xia; Chan, Kaiming; Witte, Frank; Chan, Hsiao Chang; Zheng, Yufeng#; Qin, Ling#.Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.NATURE MEDICINE. 2016. 22(10):1160-1169.
- 4. Zhang, Y. F.*; Zheng, Y. F.#; Qin, L..A comprehensive biological evaluation of ceramic nanoparticles as wear debris.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2011. 7(6):975-982.
- 5. Zhang, Y. F.*; Zheng, Y. F.#; Qin, L..The potential biohazards of nanosized wear particles at bone-prosthesis interface.ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING. 2011. 6(4):563-568.
- 6. Huang, Shuo*; Xu, Liangliang; Sun, Yuxin; Zhang, Yifeng; Li, Gang#.The fate of systemically administrated allogeneic mesenchymal stem cells in mouse femoral fracture healing.STEM CELL RESEARCH & THERAPY. 2015. 6.
- 7. Huang, Shuo*; Xu, Liangliang; Zhang, Yifeng; Sun, Yuxin; Li, Gang#.Systemic and Local Administration of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells Promotes Fracture Healing in Rats.CELL TRANSPLANTATION. 2015. 24(12):2643-2655.
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