英文信息

3D genome dynamics and developmental programing

Principal investigator

Name:

Chen HongtaoAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:

1997-2001, Tsinghua University, B.S.
2001-2004, Tsinghua University, M.S.
2006-2013, New York University, Ph.D.

Working Experience:

2013-2018, Princeton University, Lewis-Sigler Institute for Integrative Genomics, Postdoctoral Research Scholar
2018-2020, Princeton University, Center for the Physics of Biological Function, Associate Research Scholar
2020-Now, ShanghaiTech University, Assistant Professor (Tenure-track)

Group Introduction

Research Area:

Quantitative biology, nuclear biophysics and developmental programing

Research Interests:

Using a combination of genetics, genome editing, super-resolution microscopy and polymer physics, we quantitatively measure and model the movements of chromatins and study the biological implications of such movements, with a final goal of re-shaping the kinetic landscape of chromatin architectures and re-engineering the transcription programs underlying animal development and disease processes.

Group Website:

Research Achievement

We study the dynamics of 3D genome organization of eukaryotes, especially focusing on the functional implications of chromatin architectures on gene expression and developmental programing.

1) From sequence analysis and high throughput phenotyping, we discovered functions of cis-regulatory elements in cell fate determination and morphogenesis.

2) Based on genome editing, we developed a multicolor in vivo labeling system to visualize chromatin movement in developing embryos. By quantitative live imaging and kinetic modeling, we revealed a synergistic interaction between cis-regulatory element rearrangement and gene transcription.

3 ) By synthetically modulating the thermodynamic and kinetic properties of local chromatin 3D topology, we created new developmental phenotypes.

Representative Publications (*First Author, # Corresponding Author)

1. Chen HT(陈洪涛)*; Gregor T.Using RNA Tags for Multicolor Live Imaging of Chromatin Loci and Transcription in Drosophila Embryos.METHODS IN MOLECULAR BIOLOGY. 2020.
2. Chen HT(陈洪涛)*; Levo M; Barinov L; Fujioka M; Jaynes J; Gregor T^#.Dynamic interplay between enhancer-promoter topology and gene activity..NATURE GENETICS. 2018.
3. Rister J*; Razzaq A; Boodram P; Desai N; Tsanis C; Chen HT(陈洪涛); Jukam D; Desplan C^#.Single-base pair differences in a shared motif determine differential rhodopsin expression..SCIENCE. 2015.
4. Xu Z*; Chen HT(陈洪涛); Ling J; Yu D; Struffi P; Small SJ^#.Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila.GENES AND DEVELOPMENT. 2014.
5. Chen HT(陈洪涛)*; Xu Z; Mei C; Yu D; Small SJ^#.A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes.CELL. 2012.

Chen Hongtao, PhDAssistant Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo