课题组长
姓名：
惠利健中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
课题组简介
研究内容：
以肝脏细胞为研究对象，利用细胞生物学、遗传学和基因组学手段，着力于细胞命运维持与转分化、癌化等机理研究，以图揭示细胞命运转变的调控机理，从而阐明维持细胞稳定类型和功能的分子机制，并希望能为肝癌和终末期肝病治疗提供新的思路和策略。
代表性论文（*第一作者，#通讯作者）
- 1. Huang, Pengyu*; Zhang, Ludi; Gao, Yimeng; He, Zhiying; Yao, Dan; Wu, Zhitao; Cen, Jin; Chen, Xiaotao; Liu, Changcheng; Hu, Yiping; Lai, Dongmei; Hu, Zhenlei; Chen, Li; Zhang, Ying; Cheng, Xin; Ma, Xiaojun; Pan, Guoyu; Wang, Xin; Hui, Lijian#.Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes.CELL STEM CELL. 2014. 14(3):37-384.
- 2. Li, Dan*; Cen, Jin; Chen, Xiaotao; Conway, Edward M.; Ji, Yuan; Hui, Lijian#.Hepatic Loss of Survivin Impairs Postnatal Liver Development and Promotes Expansion of Hepatic Progenitor Cells in Mice.HEPATOLOGY. 2013. 58(6):219-2121.
- 3. Ji, Shuyi*; Zhang, Ludi; Hui, Lijian#.Cell fate conversion: Direct induction of hepatocyte-like cells from fibroblasts.JOURNAL OF CELLULAR BIOCHEMISTRY. 2013. 114(2):256-265.
- 4. Min, Lihua*; Ji, Yuan; Bakiri, Latifa; Qiu, Zhixin; Cen, Jin; Chen, Xiaotao; Chen, Lingli; Scheuch, Harald; Zheng, Hai; Qin, Lunxiu; Zatloukal, Kurt; Hui, Lijian#; Wagner, Erwin F.#.Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.NATURE CELL BIOLOGY. 2012. 14(11):1203+.
- 5. Huang, Pengyu*; He, Zhiying; Ji, Shuyi; Sun, Huawang; Xiang, Dao; Liu, Changcheng; Hu, Yiping; Wang, Xin; Hui, Lijian#.Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.NATURE. 2011. 475(7356):386-U142.
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