Principal investigator
Name:
Yang YangAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2001-2005, Zhejiang University, B.A.
- 2005-2010, Stony Brook University, Ph.D.
Working Experience:
- 2011-2015, Dr. Mu-ming Poo’s lab, Postdoctoral fellow
- 2015-2017, Dr. Mu-ming Poo’s lab, Associate Investigator
- 2017-Present, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Neural Basis of Learning and Memory
Research Interests:
Memory makes us who we are. The neural basis of learning and memory has always been a major research topic in neuroscience. Despite lack of neurogenesis, adult neocortex constantly goes through learning-induced synaptic remodeling, providing a mechanism for learning throughout life. In my lab, we use fear conditioning and reinforcement learning as the behavioral model, combine two-photon imaging with two-photon holographic optogenetic stimulation and genetic manipulations, to investigate neural circuit dynamics and plasticity underlying learning and memory, and how they are affected by neural modulatory systems. Eventually, we hope to understand how psychiatric disorders disrupt neural circuits and affect learning ability.
Representative Publications (*First Author, # Corresponding Author)
- 1. Yang, Yang#*; Liu, Dan-qian; Huang, Wei; Deng, Juan; Sun, Yangang; Zuo, Yi; Poo, Mu-ming.Selective synaptic remodeling of amygdalocortical connections associated with fear memory.NATURE NEUROSCIENCE. 2016. 19(10):1348.
- 2. Yang, Yang*; Zador, Anthony M.#.Differences in Sensitivity to Neural Timing among Cortical Areas.JOURNAL OF NEUROSCIENCE. 2012. 32(43):15142-15147.
- 3. Otazu, Gonzalo H.*; Tai, Lung-Hao; Yang, Yang; Zador, Anthony M.#.Engaging in an auditory task suppresses responses in auditory cortex.NATURE NEUROSCIENCE. 2009. 12(5):646-654.
- 4. Yang, Yang*; DeWeese, Michael R.; Otazu, Gonzalo H.; Zador, Anthony M.#.Millisecond-scale differences in neural activity in auditory cortex can drive decisions.NATURE NEUROSCIENCE. 2008. 11(11):1262-1263.
- 5. Liu, Jing*; Li, Linlin; Yang, Yang; Hong, Bei; Chen, Xi; Xie, Qiwei#; Han, Hua#.Automatic Reconstruction of Mitochondria and Endoplasmic Reticulum in Electron Microscopy Volumes by Deep Learning.FRONTIERS IN NEUROSCIENCE. 21 Jul 2020. 14.
- 6. Yang, Yang#*; Lu, Ju; Zuo, Yi.Changes of Synaptic Structures Associated with Learning, Memory and Diseases..BRAIN SCIENCE ADVANCES. 2018.
- 7. Sheng, Weihao*; Zhao, Xueyang; Huang, Xinrui; Yang, Yang#.Real-Time Image Processing Toolbox for All-Optical Closed-Loop Control of Neuronal Activities.FRONTIERS IN CELLULAR NEUROSCIENCE. 05 Jul 2022. 16.
- 8. Liu, Jing*; Qi, Junqian; Chen, Xi; Li, Zhenchen; Hong, Bei; Ma, Hongtu; Li, Guoqing; Shen, Lijun; Liu, Danqian; Kong, Yu; Zhai, Hao; Xie, Qiwei#; Han, Hua#; Yang, Yang#.Fear memory-associated synaptic and mitochondrial changes revealed by deep learning-based processing of electron microscopy data.CELL REPORTS. 02 Aug 2022. 40(5).
- 9. Chen, Ming*; Qi, Junqian; Poo, Muming#; Yang, Yang#.Stability and dynamics of dendritic spines in macaque prefrontal cortex.NATIONAL SCIENCE REVIEW. 29 Sep 2022. 9(9).
- 10. Shao, Zhiyong#*; Yang, Yang#; Hu, Zhitao#.Editorial: Regulation of synaptic structure and function.FRONTIERS IN MOLECULAR NEUROSCIENCE. 14 Oct 2022. 15.
Group Member and Photo
-
Name:Huang Xinrui
Position:Engineer
Duration:2017/11-now
Email:huangxr@@shanghaitech.edu.cn
-
Name:Gu Weimin
Position:Visiting Scholar
Duration:2025/01-now
Email:guweiminshtc@@hotmail.com
-
Name:Sheng Weihao
Position:Research Assistant
Duration:2025/07-now
Email:shengwh@@shanghaitech.edu.cn
-
Name:Xu Jiayue
Position:Research Professor
Duration:2020/03-now
Email:xujy@@shanghaitech.edu.cn
-
Name:Zhang Jingwei
Position:Ph.D. Student
Duration:2021/02-now
Email:zhangjw@@shanghaitech.edu.cn
-
Name:Zhang Lu
Position:Master's Student
Duration:2022/03-now
Email:zhanglu2@@shanghaitech.edu.cn
-
Name:Ren Fuqing
Position:Ph.D. Student
Duration:2023/03-now
Email:renfq2022@@shanghaitech.edu.cn
-
Name:Jiang Jun
Position:Ph.D. Student
Duration:2024/03-now
Email:jiangjun2023@@shanghaitech.edu.cn
-
Name:Zhang Qi
Position:Master's Student
Duration:2024/03-now
Email:zhangqi2023@@shanghaitech.edu.cn
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