中文信息

运动医学研究组

课题组长

姓名：

张翼锋助理教授研究员博士生导师, PhD, 助理教授

职务：

所在院所：

生命科学与技术学院

荣誉称号：

教育经历：

2001/09—2006/07，山西医科大学，第一临床医学院，学士
2007/10—2010/07，北京大学工学院，生物医学工程系，硕士
2011/09—2015/05，香港中文大学医学院，矫形外科与创伤学系，博士

博士后及工作经历：

2015/06—2019/01，南京大学医学院，助理研究员
2019/02—至今，上海科技大学，生命科学与技术学院，助理教授（TENURE-TRACK）

课题组简介

研究方向：

运动医学

研究内容：

运动系统疾病的细胞分子学机理研究、生物材料与药物研发、医疗器械及药物的临床转化等工作，促进运动医学与生命科学、物质科学、信息科学以及工程管理科学的交叉融合，推动我国自主医疗器械及药物的基础研究、产品研发、临床转化和产业化。

课题组网站：

研究成果展示

张翼峰博士及其合作者就镁金属在小动物（鼠）体内刺激骨膜下方大量新骨生成的现象，首次阐释了骨膜感觉神经末梢在镁离子刺激下大量释放成骨性的神经递质，进而诱导骨膜组织内干细胞向成骨方向分化和新骨形成的细胞分子机制。镁离子刺激骨膜下方成骨机制的阐明，意味着镁金属作为可降解的成骨性活性金属，可以被应用于临床创伤骨科的内固定植入物中。张翼峰博士与其合作者先后设计了含镁金属的中空髓内针，复合涂层镁合金螺钉，用于动物的骨折固定，并取得良好的促进骨折愈合效果。目前，张翼峰博士课题组正在将镁金属的骨科内固定植入物用于大型动物（猪）的在体手术实验，后续将进入人体临床试验，最终实现镁金属在骨科医疗器械领域的现实应用。

代表性论文（*第一作者，#通讯作者）

1. Li, Yixuan*; Zhao, Sheng; Li, Sirong; Ge, Yuxiang; Wang, Rongliang; Zheng, Liming; Xu, Jiankun; Sun, Minghui; Jiang, Qing^#; Zhang, Yifeng^#; Wei, Hui^#.Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.SMALL. 22 Nov 2019.
2. Yao, H.*; Xu, J. K.; Zheng, N. Y.; Wang, J. L.; Mok, S. W.; Lee, Y. W.; Shi, L.; Wang, J. Y.; Yue, J.; Yung, S. H.; Hu, P. J.; Ruan, Y. C.; Zhang, Yifeng; Ho, K. W.^#; Qin, L.^#.Intra-articular injection of magnesium chloride attenuates osteoarthritis progression in rats.OSTEOARTHRITIS AND CARTILAGE. Dec 2019. 27(12):1811-1821.
3. Zhang, Yifeng*; Xu, Jiankun; Ruan, Ye Chun; Yu, Mei Kuen; O'Laughlin, Micheal; Wise, Helen; Chen, Di; Tian, Li; Shi, Dufang; Wang, Jiali; Chen, Sihui; Feng, Jian Q.; Chow, Dick Ho Kiu; Xie, Xinhui; Zheng, Lizhen; Huang, Le; Huang, Shuo; Leung, Kwoksui; Lu, Na; Zhao, Lan; Li, Huafang; Zhao, Dewei; Guo, Xia; Chan, Kaiming; Witte, Frank; Chan, Hsiao Chang; Zheng, Yufeng^#; Qin, Ling^#.Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.NATURE MEDICINE. 2016. 22(10):1160-1169.
4. Zhang, Y. F.*; Zheng, Y. F.^#; Qin, L..A comprehensive biological evaluation of ceramic nanoparticles as wear debris.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2011. 7(6):975-982.
5. Zhang, Y. F.*; Zheng, Y. F.^#; Qin, L..The potential biohazards of nanosized wear particles at bone-prosthesis interface.ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING. 2011. 6(4):563-568.
6. Huang, Shuo*; Xu, Liangliang; Sun, Yuxin; Zhang, Yifeng; Li, Gang^#.The fate of systemically administrated allogeneic mesenchymal stem cells in mouse femoral fracture healing.STEM CELL RESEARCH & THERAPY. 2015. 6.
7. Huang, Shuo*; Xu, Liangliang; Zhang, Yifeng; Sun, Yuxin; Li, Gang^#.Systemic and Local Administration of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells Promotes Fracture Healing in Rats.CELL TRANSPLANTATION. 2015. 24(12):2643-2655.
8. Dai, Bingyang*; Li, Qiangqiang; Song, Xiaoxiao; Ge, Yuxiang; Wu, Jing; Zhang, Kaijia; Wang, Chao; Zhang, Yifeng; Teng, Huajian^#; Li, Chaojun^#; Jiang, Qing^#.Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice.JOURNAL OF BONE AND MINERAL METABOLISM. 2018. 36(2):133-147.
9. Yao, Hao*; Xu, Jiankun; Wang, Jiali; Zhang, Yifeng; Zheng, Nianye; Yue, Jiang; Mi, Jie; Zheng, Lizhen; Dai, Bingyang; Huang, Wenhan; Yung, Shuhang; Hu, Peijie; Ruan, Yechun; Xue, Qingyun; Ho, Kiwai; Qin, Ling.Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice.BIOACTIVE MATERIALS. May 2021. 6(5):1341-1352.
10. Duan,Kaikai*; Ling,Ziao*; Sun,Minghui; Zhi,Weiliang; Zhang,Yifeng; Han,Sheng; Xu,Jingli^#; Wang,Hui; Li,Jiusheng.A novel high mechanical and excellent hydrophilic electrospun polyurethane-silk-bioactive glass nanofiber film for rotator cuff injury repair.JOURNAL OF APPLIED POLYMER SCIENCE. Mar 2021. 139(10).
11. Xu, Jiankun*; Hu, Peijie; Zhang, Xiaotian; Chen, Junjiang; Wang, Jiali; Zhang, Jieting; Chen, Ziyi; Yu, Mei Kuen; Chung, Yiu Wa; Wang, Yan; Zhang, Xiaohu; Zhang, Yifeng; Zheng, Nianye; Yao, Hao; Yue, Jiang; Chan, Hsiao Chang; Qin, Ling^#; Ruan, Ye Chun^#.Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/beta-catenin signaling.BIOACTIVE MATERIALS. 01 Feb 2022. 8.