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科研成果

Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor 2025-03-26
Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA 2025-03-25
Ligand-Induced Ubiquitination Unleashes LAG3 Immune Checkpoint Function by Hindering Membrane Sequestration of Signaling Motifs 2025-03-17
Bridging mechanical properties with atomic structures of polymorphic α-synuclein fibrils by single-molecule analysis and molecular dynamics simulations 2025-03-13
Precise PBAEs: A Highly Efficient Single-Molecularly Defined Gene-Delivery System 2025-03-05
Lung-Specific mRNA Delivery by Ionizable Lipids with Defined Structure-Function Relationship and Unique Protein Corona Feature 2025-02-18
Targeted Delivery of mRNA with Polymer–Lipid Nanoparticles for In Vivo Base Editing 2025-02-17
Single-molecule insight into α-synuclein fibril structure and mechanics modulated by chemical compounds 2025-02-14
CRISPR-AsCas12f1 couples out-of-protospacer DNA unwinding with exonuclease activity in the sequential target cleavage 2024-11-12
10. EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection 2024-09-04
RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA–DNA hybrid cleavage 2024-08-29
12. Engineering miniature IscB nickase for robust base editing with broad targeting range 2024-07-08
13. Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex 2024-06-22
NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers 2024-06-20

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