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科研成果

Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs 2023-12-07
Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness 2023-10-31
Structural basis for activation and filamentation of glutaminase 2023-10-13
Design and application of the transformer base editor in mammalian cells and mice 2023-10-04
Base editing of organellar DNA with programmable deaminases 2023-10-04
Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity 2023-09-11
Fat body-specific reduction of CTPS alleviates HFD-induced obesity 2023-09-11
Chemical-induced phase transition and global conformational reorganization of chromatin 2023-09-09
Cas12n nucleases, early evolutionary intermediates of type V CRISPR, comprise a distinct family of miniature genome editors 2023-08-03
Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1 2023-07-31
Charging CAR by electrostatic power 2023-06-27
Modeling human ectopic pregnancies with trophoblast and vascular organoids 2023-06-27
Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility 2023-05-26
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness 2023-05-01

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