Achievement in the year of 2019


1.       The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex.

Wang S, Zhang J, He Z, Wu K, Liu XS. Int J Cancer. 2019 Nov 15;145(10):2840-2849. doi: 10.1002/ijc.32327. Epub 2019 Apr 29.


2.       Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist.

Laprairie RB, Vemuri K, Stahl EL, Korde A, Ho JH, Grim TW, Hua T, Wu Y, Stevens RC, Liu ZJ, Makriyannis A, Bohn LM. Mol Pharmacol. 2019 Nov;96(5):619-628. doi: 10.1124/mol.119.116483. Epub 2019 Sep 12.


3.    IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.

Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao GJ, Ke Z, Liu Y, Liu JN. Cell Death Dis. 2019 Oct 22;10(11):800. doi: 10.1038/s41419-019-2039-6.


4.   Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.

Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, Motzik A, Zheng M, Kang J, Zhong G, Liu C, Fang P, Guo M, Razin E, Wang J. Nat Commun. 2019 Oct 11;10(1):4664. doi: 10.1038/s41467-019-12710-8.


5.  Crystal structure of a bacterial homolog to human lysosomal transporter, spinster.

Zhou F, Yao DQ ,Rao B,Zhang L, Nie W , Zou Y , Zhao J ,Cao Y . SCIENCE BULLETIN. 2019 Sep 30; 64(18):1310-1317.


6.    A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection.

Cui C, Wang Y, Liu JN, Zhao J, Sun P, Wang S. Nat Commun. 2019 Sep 20;10(1):4298.


7.     Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Synder NW, Horng T.  Nat Immunol. 2019 Sep;20(9):1186-1195.


8.   Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing.

Li G, Liu X, Huang S, Zeng Y, Yang G, Lu Z, Zhang Y, Ma X, Wang L, Huang XX, Liu J. Mol Ther Nucleic Acids. 2019 Sep 6;17:289-296. doi: 10.1016/j.omtn.2019.05.021. Epub 2019 Jun 5.


9.   Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors.

Liu X, Li G, Zhou X, Qiao Y, Wang R, Tang S, Liu J, Wang L, Huang XX. Mol Ther Nucleic Acids. 2019 Sep 6;17:626-635. doi: 10.1016/j.omtn.2019.06.024. Epub 2019 Jul 12.


10.    Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H. Chemistry. 2019 Sep 6;25(50):11635-11640. doi: 10.1002/chem.201903190. Epub 2019 Aug 13.


11.    XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.

Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang LY, Lei H. Nucleic Acids Res. 2019 Sep 5;47(15):8239-8254. doi: 10.1093/nar/gkz532.


12.   Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.

Wang S, Cowley LA, Liu XS.Molecules. 2019 Sep 4;24(18). pii: E3214. doi: 10.3390/molecules24183214.


13.    AAV-ie enables safe and efficient gene transfer to inner ear cells.

Tan F, Chu C, Qi J, Li W, You D, Li K, Chen X, Zhao W, Cheng C, Liu X, Qiao Y, Su B, He S, Zhong C, Li H, Chai R, Zhong G. Nat Commun. 2019 Aug 19;10(1):3733.


14.    Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations.

Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y. Nat Commun. 2019 Aug 16;10(1):3703.


15.   Purification, characterization, and application of a high activity 3-ketosteroid-Delta(1)-dehydrogenase from Mycobacterium neoaurum DSM 1381.

Zhang R, Xu X, Cao H, Yuan C, Yuminaga Y, Zhao S, Shi J, Zhang B.  Appl Microbiol Biotechnol. 2019 Aug;103(16):6605-6616.


16.    Mutual inhibitions between epidermal growth factor receptor signaling and miR-124a control pancreatic progenitor proliferation.

Zhang ZW, Zhai W, Liang J, Chen Z, Ma M, Zhao Y, Liang Y, Li X, Teng CB. J Cell Physiol. 2019 Aug;234(8):12978-12988. doi: 10.1002/jcp.27967. Epub 2018 Dec 7.


17.   Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H. Chemistry. 2019 Jul 31. 


18.     Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential.

Zhang Z, Zhuang L, Lin CP.  Int J Mol Sci. 2019 Jul 25;20(15). pii: E3643.  


19.    Mammary stem cells, where art thou?

Lu P, Zhou T, Xu C, Lu Y. Wiley Interdiscip Rev Dev Biol. 2019 Jul 19:e357.


20.    Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.

Jiang SY, Tang JJ, Xiao X, Qi W, Wu S, Jiang C, Hong J, Xu J, Song BL, Luo J. PLoS Genet. 2019 Jul 19;15(7):e1008289. doi: 10.1371/journal.pgen.1008289. eCollection 2019 Jul.


21.    In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions.

Yu L#, He W#, Xie J#, Guo R#, Ni J, Zhang X, Xu Q, Wang C, Yue Q, Li F, Luo M, Sun B, Ye L, Zheng K. J Vis Exp. 2019 Jul 17;(149). doi: 10.3791/59830.


22.    Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila.

Li M, Hu X, Zhang S, Ho MS, Wu G, Zhang L. Sci Rep. 2019 Jul 12;9(1):10124.


23.   Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome.

Song X, Shan H, Zhu Y, Hu S, Xue L, Chen Y, Ding W, Niu T, Gu J, Ouyang S, Shen QT, Liu ZJ. Elife. 2019 Jul 10;8. pii: e45057. 


24.   Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair.

Li G, Zhou S, Li C, Cai B, Yu H, Ma B, Huang Y, Ding Y, Liu Y, Ding Q, He C, Zhou J, Wang Y, Zhou G, Li Y, Yan Y, Hua J, Petersen B, Jiang Y, Sonstegard T, Huang XX, Chen Y, Wang X. FEBS J. 2019 Jul 5.


25.   Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.

Lu Y, Qin S, Zhang B, Dai A, Cai X, Ma M, Gao ZG, Yang D, Stevens RC, Jacobson KA, Wang MW, Shui W. Anal Chem. 2019 Jul 2;91(13):8162-8169.


26.   Functionality-Independent DNA Encoding of Complex Natural Products.

Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu ZJ, Yang G, Lerner RA. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9254-9261.


27.   Citrate-assisted efficient local delivery of naked oligonucleotide into live mouse brain cells.

Zhou H, Zhang S, Lv F, Sun W, Wang L, Fan C, Li J, Hu J. Cell Prolif. 2019 Jul;52(4):e12622.


28.   APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems.

Kimata Y. Trends Cell Biol. 2019 Jul;29(7):591-603.


29.    Sulindac-derived retinoid X receptor-α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE-/- mice.

Shen L, Sun Z, Nie P, Yuan R, Cai Z, Wu C, Hu L, Jin S, Zhou H, Zhang X, He B. Br J Pharmacol. 2019 Jul;176(14):2559-2572. doi: 10.1111/bph.14682. Epub 2019 May 23.


30.   Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells.

Gambarotto D, Pennetier C, Ryniawec JM, Buster DW, Gogendeau D, Goupil A, Nano M, Simon A, Blanc D, Racine V, Kimata Y, Rogers GC, Basto R. Dev Cell. 2019 Jul 1;50(1):11-24.e10. doi: 10.1016/j.devcel.2019.04.036. Epub 2019 May 23.


31.   The structure-based traceless specific fluorescence labeling of the smoothened receptor

Xue D , Ye L , Zheng J , Wu Y , Zhang X , Xu Y , Li T , Stevens RC ,Xu F , Zhuang M , Zhao S , Zhao F , Tao H . Org Biomol Chem. 2019 Jun 26;17(25):6136-6142.


32.    CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists.

Liu F, Jiang W, Sui Y, Meng W, Hou L, Li T, Li M, Zhang LY, Mo J, Wang J, Zhao Y, Zhang L, Ma J, Tang Y. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. doi: 10.1073/pnas.1815780116. Epub 2019 Jun 10.


33.    Forming cytoophidia prolongs the half-life of CTP synthase.

Sun Z, Liu JL. Cell Discov. 2019 Jun 18;5:32.


34.    Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.

Gao H, Wen H, Cao C, Dong D, Yang C, Xie S, Zhang J, Huang X, Huang XX, Yuan S, Dong W. Front Physiol. 2019 Jun 18;10:765.


35.    In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.

Shi X, Chen M, Yu Z, Bell JM, Wang H, Forrester I, Villarreal H, Jakana J, Du DJ, Luisi BF, Ludtke SJ, Wang Z. Nat Commun. 2019 Jun 14;10(1):2635.


36.    Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.

Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang XX, Wang L, Chen X, Zhang L. Mol Ther Nucleic Acids. 2019 Jun 7;16:494-504.


37.   Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.

Zhang S, Lv F, Yuan Y, Fan C, Li J, Sun W, Hu J. Front Neurosci. 2019 Jun 4;13:565.


38.   A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.

Shang C, Liu A, Li D, Xie Z, Chen Z, Huang M, Li Y, Wang Y, Shen WL, Cao P. Nat Neurosci. 2019 Jun;22(6):909-920.


39.   Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.

Zhao ZD, Chen Z, Xiang X, Hu M, Xie H, Jia X, Cai F, Cui Y, Chen Z, Qian L, Liu J, Shang C, Yang Y, Ni X, Sun W, Hu J, Cao P, Li H, Shen WL. Nat Neurosci. 2019 Jun;22(6):921-932.


40.    Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.

Huang X, Feng T, Jiang Z, Meng J, Kou S, Lu Z, Chen W, Lin CP, Zhou B, Zhang H. J Biol Chem. 2019 May 31;294(22):8894-8906.


41.    Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo.

Huang S, Liao Z, Li X, Liu Z, Li G, Li J, Lu Z, Zhang Y, Li XJ, Ma X, Sun Q, Huang XX. iScience. 2019 May 31;15:640-648.


42.   Molecular Mechanism of Acetate Transport through the Acetate Channel SatP.

Wu M, Sun L, Zhou Q, Peng Y, Liu ZJ, Zhao S. J Chem Inf Model. 2019 May 28;59(5):2374-2382. 


43.   A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells.

Li F, Jiang X, Luo LL, Xu YM, Huang XX, Huang C, Zhang Y. Cell Commun Signal. 2019 May 23;17(1):49.


44.   Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region.

Ma HH, Tu LC, Chung YC, Naseri A, Grunwald D, Zhang S, Pederson T. J Cell Biol. 2019 May 6;218(5):1467-1477.


45.    Central Processing of Itch in the Midbrain Reward Center.

Su XY, Chen M, Yuan Y, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG, Hu J, Xu TL. Neuron. 2019 May 22;102(4):858-872.e5.


46.    CCN1-Induced Cellular Senescence Promotes Heart Regeneration.

Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H. Circulation. 2019 May 21;139(21):2495-2498.


47.    Model-based understanding of single-cell CRISPR screening.

Duan B, Zhou C, Zhu C, Yu Y, Li G, Zhang S, Zhang C, Ye X, Ma HH, Qu S, Zhang Z, Wang P, Sun S, Liu Q. Nat Commun. 2019 May 20;10(1):2233.


48.    Wingless modulates activator protein-1-mediated tumor invasion.

Zhang SP, Guo X, Wu H, Sun Y, Ma X, Li J, Xu Q, Wu C, Li Q, Jiang C, Li W, Ho MS, Lv Z, Xue L. Oncogene. 2019 May;38(20):3871-3885.


49.    Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning.

Li D, Zavaglia M, Wang G, Xie H, Hu Y, Werner R, Guan JS, Hilgetag CC. Sci Rep. 2019 May 15;9(1):7424.


50.    Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics.

Wang Z, Liang H, Cao H, Zhang B, Li J, Wang W, Qin S, Wang Y, Xuan L, Lai L, Shui WQ. Analyst. 2019 May 7;144(9):2881-2890. 


51.    Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.

Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, Sun B, Li X, Liu C, Li D. Nat Commun. 2019 May 1;10(1):2006.


52.    Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies.

Sun B. Mol Cell Biol. 2019 Apr 30;39(10). pii: e00576-18.


53.   Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells.

Hu B, Zou Y, Zhang L, Tang J, Niedermann G, Firat E, Huang XX, Zhu X. Hum Gene Ther. 2019 Apr;30(4):446-458.  


54.   Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation.

Ma H, Zhang BL, Liu BY, Shi S, Gao DY, Zhang TC, Shi HJ, Li Z, Shum WW. iScience. 2019 Apr 26;14:210-225.


55.    Critical role of spectrin in hearing development and deafness.

Liu Y, Qi J, Chen X, Tang M, Chu C, Zhu W, Li H, Tian C, Yang G, Zhong C, Zhang Y, Ni G, He SJ, Chai R, Zhong GS. Sci Adv. 2019 Apr 17;5(4):eaav7803. 


56.    Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.

Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao PL, Chu Y, Lu X, Li W, Yu H, Kang J. Mol Biol Cell. 2019 Apr 15;30(9):1060-1068.


57.   Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.

Yuan Y, Wu W, Chen M, Cai F, Fan C, Shen W, Sun WZ, Hu J. Curr Biol. 2019 Apr 1;29(7):1243-1251.e4.  


58.    Amyloid structure of high-order assembly of Leucine-rich amelogenin revealed by solid-state NMR.

Ma CW, Zhang J, Dong XQ, Lu JX. J Struct Biol. 2019 Apr 1;206(1):29-35.


59.     Development and Application of Base Editors.

Yang B, Yang L, Chen J.CRISPR J. 2019 Apr;2(2):91-104. doi: 10.1089/crispr.2019.0001.


60.    A Chemical Strategy for Amphiphile Replacement in Membrane Protein Research.

Xue D, Wang J, Song X, Wang W, Hu T, Ye L, Liu Y, Zhou Q, Zhou F, Jiang ZX, Liu ZJ, Tao H. Langmuir. 2019 Mar 26;35(12):4319-4327.


61.    Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.

Wang G, Xie H, Wang L, Luo W, Wang Y, Jiang J, Xiao C, Xing F, Guan JS. Cereb Cortex. 2019 Mar 19. pii: bhz050. 


62.    Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes

Zhou PJ, Wang X, An N, Wei L, Zhang L, Huang XX, Zhu HH, Fang YX, Gao WQ. Oncogene. 2019 Mar;38(12):2192-2205.


63.    Glia in Health and Disease

Ho MS, Verkhratsky A, Duan S, Parpura V. Front Mol Neurosci. 2019 Mar 19;12:63.


64.    Cytoophidia respond to nutrient stress in Drosophila

Wu Z, Liu JL. Exp Cell Res. 2019 Mar 15;376(2):159-167.


65.   CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features.

Kartha VK, Sebastiani P, Kern JG, Zhang LY, Varelas X, Monti S. Front Genet. 2019 Feb 19;10:121. 


66.    A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.

Qi J, Liu Y, Chu C, Chen X, Zhu W, Shu Y, He SJ, Chai R, Zhong GS. Cell Discov. 2019 Feb 19;5:12.


67.    Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants.

Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao GJ. Dev Cell. 2019 Feb 11;48(3):406-419.e5.


68.    mTOR Is Key to T Cell Transdifferentiation.

Yan J, Wang R, Horng T. Cell Metab. 2019 Feb 5;29(2):241-242.


69.   Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome.

Li J, Liu Z, Huang S, Wang X, Li G, Xu Y, Yu W, Chen S, Zhang Y, Ma HH, Ke Z, Chen J, Sun Q, Huang XX. Cell Res. 2019 Feb;29(2):174-176.


70.    Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.

Hou L , Zhao J, Gao S, Ji T, Song T, Li Y, Wang J, Geng C, Long M, Chen J, Lin H, Cai X, Cang Y. Sci Adv. 2019 Feb 6;5(2):eaau7130. doi: 10.1126/sciadv.aau7130. eCollection 2019 Feb.


71.   mTOR-S6K1 pathway mediates cytoophidium assembly.

Sun Z, Liu JL.J Genet Genomics. 2019 Feb;46(2):65-74. doi: 10.1016/j.jgg.2018.11.006. Epub 2019 Jan 31.


72.    Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer.

Liu W , Zhang Z , Zhang ZM , Hao PL, Ding K , Li Z . Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599.


73.    Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus.

Luo F, Mu Y, Gao C, Xiao Y, Zhou Q, Yang Y, Ni X,Shen WL, Yang J. J Genet Genomics. 2019 Jan 20;46(1):31-40.


74.   Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao SW, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Cell. 2019 Jan 24;176(3):459-467.e13.


75.    Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

Zhang B, Li J, Yang X, Wu L, Zhang J, Yang Y, Zhao Y, Zhang L, Yang X, Yang X, Cheng X, Liu ZJ, Jiang B, Jiang H, Guddat LW, Yang HT, Rao Z. Cell. 2019 Jan 24;176(3):636-648.e13.


76.    A Tet/Q Hybrid System for Robust and Versatile Control of Transgene Expression in C. elegans.

Mao S, Qi Y, Zhu H, Huang X, Zou Y, Chi T. iScience. 2019 Jan 25;11:224-237. doi: 10.1016/j.isci.2018.12.023. Epub 2018 Dec 27.


77.    Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones.

Ai H, Guo Y, Sun D, Liu S, Qi Y, Guo J, Qu Q, Gong Q, Zhao S, Li J, Liu L. Chembiochem. 2019 Jan 18;20(2):221-229. doi: 10.1002/cbic.201800432. Epub 2018 Nov 21.


78.    Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening.

Guo C , Chang Y , Wang X , Zhang C , Hao PL , Ding K , Li Z . Chem Commun (Camb). 2019 Jan 15;55(6):834-837.


79.     Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, Zhou S, Wang YA, Fuller GN, Huse J, Gilboa E, Kang N, Huang XX, Verhaak R, Li S, Heimberger AB1. J Clin Invest. 2019 Jan 2;129(1):137-149.


80.   Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC. Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3.


81.    Principles Governing Catalytic Activity of Self-Assembled Short Peptides.

 Song R, Wu X, Xue B, Yang Y, Huang W, Zeng G, Wang J, Li W, Cao Y, Wang W, Lu JX, Dong H. J Am Chem Soc. 2019 Jan 9;141(1):223-231. doi: 10.1021/jacs.8b08893. Epub 2018 Dec 28.


82.   Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.

Yang G, Zhou C, Wang R, Huang S, Wei Y, Yang X, Liu Y, Li J, Lu Z, Ying W, Li XJ, Jing N, Huang XX, Yang H, Qiao Y. Cell Rep. 2019 Jan 8;26(2):302-312.e4.


83.   Metabolism as a guiding force for immunity

Jung J, Zeng H, Horng T. Nat Cell Biol. 2019 Jan;21(1):85-93.


84.   Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals

Zhao Yu; Liu, Changbo; Liu, Zhixiang; Luo, Wenhan; Li, Lizhu; Cai, Xue; Liang, Dong; Su, Yuanzhe; Ding, He; Wang, Qiang; Yin, Lan; Guan, JS; Luo, Minmin; Sheng, Xing. IEEE TRANS.ELECTRON DEVICES.2019 Jan; 66(1):785-792.


85.   A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity.

Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, Peng Z, Tai YT, Hideshima T, Anderson KC, Cang Y. Leukemia. 2019 Jan;33(1):171-180.


86.    AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building.

Li XY, Han Y, Zhang W, Wang SR, Wei YC, Li SS, Lin JK, Yan JJ, Chen AX, Zhang X, Zhao ZD, Shen W, Xu XH. J Neurosci. 2019 Jan 16;39(3):456-471.



Achievement in the year of 2018


1.       A Shared Neural Node for Multiple Innate Behaviors in Drosophila.

Ho MSNeurosci Bull. 2018 Dec;34(6):1103-1104. doi: 10.1007/s12264-018-0311-x. Epub 2018 Nov 9


2.       Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.

Jiang SY, Li H, Tang JJ, Wang J, Luo J, Liu B, Wang JK, Shi XJ, Cui HW, Tang J, Yang F, Qi W, Qiu WW, Song BL. Nat Commun. 2018 Dec 3;9(1):5138. doi: 10.1038/s41467-018-07590-3.


3.       Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors.

Zhang X, Dong S, Xu F. TRENDS IN BIOCHEMICAL SCIENCES, 2018,43(12):1033-1046. doi: 10.1016/j.tibs.2018.09.002. Epub 2018 Oct 8.


4.       α-Synuclein Trafficking in Parkinson's Disease: Insights From Fly and Mouse Models.

Cheng J, Lu Q, Song L, Ho MSASN Neuro. 2018 Jan-Dec;10:1759091418812587. doi: 10.1177/1759091418812587.


5.       Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.

Chiu H, Zou Y, Suzuki N, Hsieh YW, Chuang CF, Wu YC, Chang C. Nat Commun. 2018 Nov 19;9(1):4842. doi: 10.1038/s41467-018-07291-x.


6.       CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo.

Meng W, Wang J, Wang B, Liu F, Li M, Zhao Y, Zhang C, Li Q, Chen J, Zhang LY, Tang Y, Ma J. Cancer Manag Res. 2018 Nov 15;10:5747-5758. doi: 10.2147/CMAR.S183696. eCollection 2018.


7.       Solid-State NMR Identification of Intermolecular Interactions in Amelogenin Bound to Hydroxyapatite.

Arachchige RJ, Burton SD, Lu JX, Ginovska B, Harding LK, Taylor ME, Tao J, Dohnalkova A, Tarasevich BJ, Buchko GW, Shaw WJ.  Biophys J. 2018 Nov 6;115(9):1666-1672. doi: 10.1016/j.bpj.2018.08.027. Epub 2018 Aug 29.


8.       Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos.

Zeng Y, Li J, Li G, Huang S, Yu W, Zhang Y, Chen D, Chen J, Liu J, Huang XXMol Ther. 2018 Nov 7;26(11):2631-2637. doi: 10.1016/j.ymthe.2018.08.007. Epub 2018 Aug 14


9.       Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.

Li J, Tang JX, Cheng JM, Hu B, Wang YQ, Aalia B, Li XY, Jin C, Wang XX, Deng SL, Zhang Y, Chen SR, Qian WP, Sun QY, Huang XX, Liu YX.  J Cell Biol. 2018 Nov 5;217(11):3901-3911. doi: 10.1083/jcb.201802077. Epub 2018 Aug 10.


10.   Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion.

Wang X, Li J, Wang Y, Yang B, Wei J, Wu J, Wang R, Huang XXChen J, Yang L.  Nat Biotechnol. 2018 Nov;36(10):946-949. doi: 10.1038/nbt.4198. Epub 2018 Aug 20


11.   The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.

Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, Ma X, He L, Wu W, Yin M, Ge L, Wang Z, Ho MS, Zhao Y, Fei Z, Zhang L. J Biol Chem. 2018 Nov 2;293(44):17119-17134. doi: 10.1074/jbc.RA118.003608. Epub 2018 Sep 12.


12.   Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9.

Zhou S, Yu H, Zhao X, Cai B, Ding Q, Huang Y, Li Y, Li Y, Niu Y, Lei A, Kou Q, Huang XX, Petersen B, Ma B, Chen Y, Wang X. Reprod Fertil Dev. 2018 Nov;30(12):1616-1621. doi: 10.1071/RD18086.


13.   CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging.

Ma H, Tu LC, Naseri A, Chung YC, Grunwald D, Zhang S, Pederson T. Nat Methods. 2018 Nov;15(11):928-931. doi: 10.1038/s41592-018-0174-0. Epub 2018 Oct 30.


14.   m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.

Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y,Patel MJ, Cao X, Shen B, Huang XX. Ming GL, Zhuang X, Song H, He C, Zhou T.    Nature. 2018 Nov;563(7730):249-253. doi: 10.1038/s41586-018-0666-1. Epub 2018 Oct 31.


15.   Active transport of cytoophidia in Schizosaccharomyces pombe.

Li H, Ye F, Ren JY, Wang PY, Du LL, Liu JL.  FASEB J. 2018 Nov;32(11):5891-5898. doi: 10.1096/fj.201800045RR. Epub 2018 May 21.


16.   Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection.

Li Z, Lu Y, Guo Y, Cao H, Wang Q, Shui WANALYTICA CHIMICA ACTA, 2018 Oct 31;1029:50-57. doi: 10.1016/j.aca.2018.05.001. Epub 2018 May 4.


17.   Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target.

Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B. Cell Rep. 2018 Oct 30;25(5):1241-1254.e5. doi: 10.1016/j.celrep.2018.10.015.


18.   Transcription initiation defines kinetoplast RNA boundaries.

Sement FM, Suematsu T, Zhang LY, Yu T, Huang L, Aphasizheva I, Aphasizhev R.  Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10323-E10332. doi: 10.1073/pnas.1808981115. Epub 2018 Oct 17.


19.   Filamentation of asparagine synthetase in Saccharomyces cerevisiae.

Zhang S, Ding K,, Shen QJ, Zhao SLiu JL.  PLoS Genet. 2018 Oct 26;14(10):e1007737. doi: 10.1371/journal.pgen.1007737. eCollection 2018 Oct.


20.   Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.

Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y. Nat Commun. 2018 Oct 11;9(1):4224. doi: 10.1038/s41467-018-06627-x.


21.   Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4.

Zhao K, Shen C, Li L, Wu H, Xing G, Dong Z, Jing H, Chen W, Zhang H, Tan Z, Pan J, Xiong L, Wang H, Cui W, Sun XD, Li S, Huang X, Xiong WC, Mei L. J Neurosci. 2018 Oct 10;38(41):8860-8873. doi: 10.1523/JNEUROSCI.0860-18.2018. Epub 2018 Aug 31.


22.   Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats.

Li C, Zhou S, Li Y, Li G, Ding Y, Li L, Liu J, Qu L, Sonstegard T Huang XX, Jiang Y, Chen Y, Petersen B, Wang X.  Front Genet. 2018 Oct 4;9:449. doi: 10.3389/fgene.2018.00449. eCollection 2018.


23.   Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.

Zhang J, Wang Z, Zhang S, Chen Y Xiong X, Li X, Tonks NK, Fan GF.  Cell Signal. 2018 Oct;50:100-110. doi: 10.1016/j.cellsig.2018.06.006. Epub 2018 Jun 18.  


24.   Interfilament interaction between IMPDH and CTPS cytoophidia.

Chang CC, Keppeke GD, Sung LY, Liu JL.  FEBS J. 2018 Oct;285(20):3753-3768. doi: 10.1111/febs.14624. Epub 2018 Aug 31.


25.   A post-ingestive amino acid sensor promotes food consumption in Drosophila.

Yang Z, Huang R, Fu X, Wang G, Qi W, Mao D, Shi Z, Shen WL, Wang L,A.  Cell Res. 2018 Oct; 28(10):1013-1025. doi: 10.1038/s41422-018-0084-9. Epub 2018 Sep 12.


26.   CRISPR-Mediated Recording of Mouse Development.

Sun JL. CRISPR J. 2018 Oct;1:314-316. doi: 10.1089/crispr.2018.29036.jls.


27.   Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6.

Fang Yuan, Xin Chen, Kai-Heng Fang, Yuanyuan Wang, Mingyan Lin, Shi-Bo Xu, Hai-Qin Huo, Min Xu, Lixiang Ma, Yuejun Chen, He SJ , Yan Liu.    Elife. 2018 Sep 25;7. pii: e37382. doi: 10.7554/eLife.37382.


28.   Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP.

GuangYang,TianyuZhu,ZongyangLu,GuangleiLi,HaoZhang,SongjieFeng,YajingLiu,JiananLiaYuZhang, Chen J, XuejiangGuo,  Huang XX,  Science Bulletin   2018 Sep 15;63(17):1101-1107. doi: 10.1016/j.scib.2018.07.002.


29.   Mammillary body regulates state-dependent fear by alternating cortical oscillations.

Jiang J, Wang GY, Luo W, Xie H, Guan JS. Sci Rep. 2018 Sep 7;8(1):13471. doi: 10.1038/s41598-018-31622-z.


30.   Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.

Lin WC, Chakraborty A, Huang SC Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM.  Cell Rep. 2018 Sep 4;24 (10):2733-2745.e7. doi: 10.1016/j.celrep.2018.08.007.


31.   Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins.

Qu L, Jiang Y, Cheng C, Wu D, Meng B, Chen Z, Zhu Y, Shaw N, Ouyang S, Liu ZJ. Structure. 2018 Sep 4;26(9):1259-1265.e3. doi: 10.1016/j.str.2018.05.019. Epub 2018 Jul 12.


32.   A proximity-tagging system to identify membrane protein-protein interactions.

Liu Q, Zheng J, Sun W, Huo Y, Zhang L,  Wang HPZhuang M.  Nat Methods. 2018 Sep;15(9):715-722. doi: 10.1038/s41592-018-0100-5. Epub 2018 Aug 13.


33.   Discrimination and quantification of homologous keratins from goat and sheep with dual protease digestion and PRM assays.

Miao C, Yang Y, Li S, Guo Y, Shui W, Cao Q. J Proteomics. 2018 Aug 30;186:38-46. doi: 10.1016/j.jprot.2018.07.010. Epub 2018 Jul 17.


34.   Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.

Wang YS, Zhang B, Zhu J, Yang CL, Guo Y, Liu CL, Liu F, Huang H, Zhao S, Liang Y, Jiao RH, Tan RX, Ge HM. J Am Chem Soc. 2018 Aug 29;140(34):10909-10914. doi: 10.1021/jacs.8b06623. Epub 2018 Aug 15.


35.   Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.

He L, Gu W, Wang M, Chang X, Sun X, Zhang Y, Lin X,Yan C, Fan W, Su P, Wang Y, Yi C, Lin G, Li L, Jiang Y, Lu JX, Dong C, Wang H,Sun B.  Proc Natl Acad Sci U S A. 2018 Aug 21;115 (34):8621-8626. doi: 10.1073/pnas.1801196115. Epub 2018 Aug 7.


36.   Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC,, Melcher K, Zhao S, Xu F.  Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.


37.   Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation.

Zhou J, Zhao S, Dunker AK. J Mol Biol. 2018 Aug 3;430(16):2342-2359. doi: 10.1016/j.jmb.2018.03.028. Epub 2018 Apr 4.


38.   miR-221/222 activate the Wnt/beta-catenin signaling to promote triple-negative breast cancer.

Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H. J Mol Cell Biol. 2018 Aug 1;10(4):302-315. doi: 10.1093/jmcb/mjy041.


39.   Real-time observation of nucleoplasmin-mediated DNA decondensation and condensation reveals its specific functions as a chaperone.

Huo XM, Meng LF, Jiang T, Li M Sun FZ, Sun B, Li JK.  Biochim Biophys Acta Gene Regul Mech. 2018 Aug;1861(8):743-751. doi: 10.1016/j.bbagrm.2018.07.002. Epub 2018 Jul 21.


40.   BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity.

Jiang W, Feng S, Huang S, Yu W, Li G, Yang G, Liu Y, Zhang Y, Zhang L, Hou Y, Chen J, Chen J, Huang XX.  Cell Res. 2018 Aug;28(8):855-861. doi: 10.1038/s41422-018-0052-4. Epub 2018 Jun 6.


41.   Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats.

Ma Y, Yu L, Zhang X, Xin C Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, Huang XX, Zhang L.  Cell Discov. 2018 Jul 17;4:39. doi: 10.1038/s41421-018-0047-9. eCollection 2018.


42.   Exploring a new ligand binding site of G protein-coupled receptors.

Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.


43.   3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues A beta 42-Induced Loss of Human Neural Stem Cell Plasticity.

Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He SJAntos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C.  Dev Cell. 2018 Jul 2;46(1):85-101.e8. doi: 10.1016/j.devcel.2018.06.005.


44.   2-Thiophene ethylamine modified hyaluronic acid with its application on hepatocytes culture.

Wang L, Zhou Y, Dai J, Jiang S Lu Y, Sun M, Gong J, Huang PY, Yao Y.  Mater Sci Eng C Mater Biol Appl.2018 Jul 1;88:157-165. doi: 10.1016/j.msec.2018.03.009. Epub 2018 Mar 20.


45.   APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.

Wang S, Jia M, He Z, Liu XS.   Oncogene. 2018 Jul;37 (29):3924-3936. doi: 10.1038/s41388-018-0245-9. Epub 2018 Apr 26.


46.   Protein crystal quality oriented disulfide bond engineering.

Pu M, Xu Z, Peng Y, Hou Y, Liu D, Wang Y, Liu H, Song G, Liu ZJ. Protein Cell. 2018 Jul;9(7):659-663. doi: 10.1007/s13238-017-0482-7.


47.   Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.

Yao XP, Cheng X, Wang C, Zhao M, Guo XX, Su HZ, Lai LL, Zou XH, Chen X,J Zhao Y, Dong EL, Lu YQ, Wu S, Li X, Fan GF, Yu H, Xu J, Wang N, Xiong ZQ, Chen WJ.  Neuron. 2018 Jun 27;98(6):1116-1123.e5. doi: 10.1016/j.neuron.2018.05.037. Epub 2018 Jun 14.


48.   DeepCRISPR: optimized CRISPR guide RNA design by deep learning.

Chuai G, Ma H, Yan J, Chen M, Hong N, Xue D, Zhou C, Zhu C, Chen K, Duan B, Gu F, Qu S, Huang D, Wei J, Liu Q. Genome Biol. 2018 Jun 26;19(1):80. doi: 10.1186/s13059-018-1459-4.


49.   Computational design of thermostabilizing point mutations for G protein-coupled receptors.

Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V. Elife. 2018 Jun 21;7. pii: e34729. doi: 10.7554/eLife.34729.


50.   Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells.

Yang CS, Stampouloglou E, Kingston NM, Zhang LY, Monti S, Varelas X.  EMBO Rep. 2018 Jun; 19(6):e43577. doi: 10.15252/embr.201643577. Epub 2018 Apr 16


51.   Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing.

Liu Z, Lu Z, Yang G, Huang S, Li G, Feng S, Liu Y, Li J, Yu W, Zhang Y, Chen J, Sun Q ,Huang XX.  Nat Commun. 2018 Jun 14; 9(1):2338. doi: 10.1038/s41467-018-04768-7.


52.   IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.

Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY, Liu JL.  Cell Div. 2018 Jun 15;13:5. doi: 10.1186/s13008-018-0038-0. eCollection 2018.


53.   Helicase promotes replication re-initiation from an RNA transcript.

Sun B, Singh A, Sultana S, Inman JT, Patel SS, Wang MD.  Nat Commun. 2018 Jun 13; 9(1):2306. doi: 10.1038/s41467-018-04702-x.


54.   TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs.

Yang X, Wang R, Wang X, Cai G, Qian Y, Feng S, Tan F, Chen K, Tang K, Huang XX, Jing N, Qiao Y.  J Mol Cell Biol. 2018 Jun 1;10(3):216-228. doi: 10.1093/jmcb/mjy013.


55.   A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT, Song BL.  Science. 2018 Jun 8;360(6393):1087-1092. doi: 10.1126/science.aao6575.


56.   Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate.

Qiu B, Xia B, Zhou Q, Lu Y,  He M,  Hasegawa K, Ma Z, Zhang F, Gu L, Mao Q, Wang F, Zhao S, Gao Z, Liao J.     Cell Res. 2018 Jun;28(6):644-654. doi: 10.1038/s41422-018-0032-8. Epub 2018 Mar 27.


57.   The Future of Genome Editing.

April Pawluk, Chen J, Prashant Mali, and Weizhi Ji.   Cell Volume.2018 May31;173(6): 1311-1313.


58.   Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep.

Wang X, Liu J, Niu Y, Li Y, Zhou S, Li C, Ma B, Kou Q, Petersen B, Sonstegard T, Huang XX, Jiang Y, Chen Y.  BMC Genomics. 2018 May 25;19(1):397. doi: 10.1186/s12864-018-4712-z.


59.   Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors.

Liu X, Gao Z, Wu Y, Stevens RC, Kenneth A. J, Zhao S WSci Rep. 2018 May 24;8(1):8084. doi: 10.1038/s41598-018-26577-0.


60.   Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.

Zhang J, Liu X, Xu W, Luo W, Li M, Chu F, Xu L, Cao A, Guan J, Tang S, Duan X. Nano Lett. 2018 May 9;18(5):2903-2911. doi: 10.1021/acs.nanolett.8b00087. Epub 2018 Apr 9.


61.   Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock.

Xiao W, Duan X, Lin Y, Cao Q, Li S, Guo Y, Gan Y, Qi X, Zhou Y, Guo L, Qin P, Wang Q, Shui W. J Proteome Res. 2018 May 4;17(5):1812-1825. doi: 10.1021/acs.jproteome.7b00842. Epub 2018 Apr 9.


62.   Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.

Shang W, Jiang Y, Boettcher M, Ding K, Mollenauer M, Liu Z, Wen X, Liu C, Hao PZhao S, McManus MT, Wei L, Weiss A, Wang HP.  Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4051-E4060. doi: 10.1073/pnas.1801340115. Epub 2018 Apr 9.


63.   Base editing with a Cpf1-cytidine deaminase fusion.

Li X, Wang Y, Liu Y, Yang B, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X, Yang L, Chen J.  Nat Biotechnol. 2018 Apr;36(4):324-327. doi: 10.1038/nbt.4102. Epub 2018 Mar 19.


64.   Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart.

Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B.  Circ Res. 2018 Mar 30;122(7):984-993. doi: 10.1161/CIRCRESAHA.117.312354. Epub 2018 Jan 26.


65.   CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy.

Yao X, Wang X, Liu J, Shi L, Huang PY, Yang H. J Vis Exp. 2018 Mar 12;(133). doi: 10.3791/56844.


66.   Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.

Yan C, Huo H, Yang C, Zhang T, Chu Y, Liu YF.  Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733. doi: 10.1016/j.bbrc.2018.02.140. Epub 2018 Feb 17.


67.   Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration.

Zhang H, Lui KO, Zhou B.  Circ Res. 2018 Mar 2;122(5):774-789. doi: 10.1161/CIRCRESAHA.117.312136.


68.   In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.

Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, Hu X, Li C, Yao X, Shen X, Sun Y, Wei Y, Liu F, Ying W, Zhang J, Tang C, Zhang X, Xu H, Shi L, Cheng L, Huang PY, Yang H.  Nat Neurosci. 2018 Mar;21(3):440-446. doi: 10.1038/s41593-017-0060-6. Epub 2018 Jan 15.


69.   Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination.

Cui Y, Niu Y, Zhou J, Chen Y, Cheng Y, Li S, Ai Z, Chu C, Wang H, Zheng B, Chen X, Sha J, Guo X, Huang XX, Ji W.  Cell Res. 2018 Mar;28(3):383-386. doi: 10.1038/cr.2018.10. Epub 2018 Jan 12.


70.   Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer.

Yu H, Long W, Zhang X, Xu K, Guo J, Zhao H, Li H, Qing Y, Pan W, Jia B, Zhao HY, Huang XX, Wei HJ.  J Transl Med. 2018 Feb 27;16(1):41. doi: 10.1186/s12967-018-1409-7.


71.   High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.

Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, Hanson MA, Liu ZJ, Wang MW,Stevens RC, Shui W.  Chem Sci. 2018 Feb 20;9(12):3192-3199. doi: 10.1039/c7sc04698g. eCollection 2018 Mar 28.


72.   Implantable and Biodegradable Poly(l‐lactic acid) Fibers for Optical Neural Interfaces.

Ruxing Fu, Wenhan Luo, Roya Nazempour, Daxin Tan, He Ding, Kaiyuan Zhang, Lan Yin, Guan JS, Xing Sheng.  Advanced Optical Materials . 2018 Feb 5;6(3). 1700941 doi: 10.1002/adom.201700941


73.   Lateral habenula in the pathophysiology of depression.

Yang Y, Wang H, Hu J, Hu H.  Curr Opin Neurobiol. 2018 Feb;48:90-96. doi: 10.1016/j.conb.2017.10.024. Epub 2017 Nov 23.


74.   5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K0, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S0, Gloriam DE, Roth BL, Stevens RC, Liu ZJ. Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1.


75.   Production of Wilson Disease Model Rabbits with Homology-Directed Precision Point Mutations in the ATP7B Gene Using the CRISPR/Cas9 System.

Jiang W, Liu L, Chang Q, Xing F, Ma Z, Fang Z, Zhou J, Fu L, Wang H, Huang XX, Chen X, Li Y, Li S. Sci Rep. 2018 Jan 22;8(1):1332. doi: 10.1038/s41598-018-19774-4


76.   Clonal analysis of lineage fate in native haematopoiesis.

Rodriguez-Fraticelli AE, Wolock SL, Weinreb CS, Panero R, Patel SH, Jankovic M, Sun JL, Calogero RA, Klein AM, Camargo FD.  Nature. 2018 Jan 11;553(7687):212-216. doi: 10.1038/nature25168. Epub 2018 Jan 3.


77.   Genomic Tagging of AGO1 Using CRISPR/Cas9-Mediated Homologous Recombination.

Ghosh S, Liu JL.  Methods Mol Biol. 2018;1680:217-235. doi: 10.1007/978-1-4939-7339-2_15. 


78.   APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.

Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang MHuang XX, Shen B, Yang L, Chen J.  Nat Struct Mol Biol. 2018 Jan;25(1):45-52. doi: 10.1038/s41594-017-0004-6. Epub 2017 Dec 11.


79.   Efficient generation of goats with defined point mutation (I397V) in GDF9 through CRISPR/Cas9.

Niu Y, Zhao X, Zhou J, Li Y, Huang Y, Cai B, Liu Y, Ding Q, Zhou S, Zhao J, Zhou G, Ma B, Huang XX, Wang X, Chen Y.  Reprod Fertil Dev. 2018 Jan;30(2):307-312. doi: 10.1071/RD17068.


80.   CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.

Song T, Liang S, Liu J, Zhang T, Yin Y, Geng C, Gao S, Feng Y, Xu H, Guo D, Roberts A, Gu Y, Cang Y.  PLoS Genet. 2018 Jan 25;14(1):e1007165. doi: 10.1371/journal.pgen.1007165. eCollection 2018 Jan.


81.   Identification of natural products as novel ligands for the human 5-HT2C receptor.

Peng Y, Zhao S, Wu Y, Cao H, Xu Y, Liu X, Shui W, Cheng J, Zhao S, Shen L, Ma J, Quinn RJ, Stevens RC, Zhong G, Liu ZJ. Biophys Rep. 2018;4(1):50-61. doi: 10.1007/s41048-018-0047-1. Epub 2018 Mar 9.



Achievement in the year of 2017


1.       CTP synthase forms the cytoophidium in human hepatocellular carcinoma.

Chang CC, Jeng YM, Peng M, Keppeke GD, Sung LY, Liu JL.  Exp Cell Res. 2017 Dec 15;361(2):292-299. doi: 10.1016/j.yexcr.2017.10.030. Epub 2017 Oct 31.


2.       Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance of Active DNA Methylation Changes in Rat Sperm.

Zheng X, Li Z, Wang G, Li Z, Liang A, Wang H, Dai Y, Huang XX, Chen X, Ma Y, Sun F. Front Genet. 2017 Dec 12;8:207. doi: 10.3389/fgene.2017.00207. eCollection 2017.


3.       Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.

Yang W, Pan W, Chen S, Trendel N, Jiang S, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O, Li H, Xu C. Nat Struct Mol Biol. 2017 Dec;24(12):1081-1092. doi: 10.1038/nsmb.3489. Epub 2017 Oct 23.


4.        Pericentral hepatocytes produce insulin-like growth factor-2 to promote liver regeneration during selected injuries in mice.

Liu J, Hu X, Chen J, Li X, Wang L, Wang B, Peng W, Yang C, Li Z, Chen Y, Wang YJ, Li C, Li X, Yan F, Wang Y, Shang C, Wang X, Chen T, Huang P. Hepatology. 2017 Dec;66(6):2002-2015. doi: 10.1002/hep.29340. Epub 2017 Nov 6.


5.       Structural insights into the committed step of bacterial phospholipid biosynthesis.

Li Z, Tang Y, Wu Y, Zhao S, Bao J, Luo Y, Li D. Nat Commun. 2017 Nov 22;8(1):1691. doi: 10.1038/s41467-017-01821-9.


6.       Ligand identification of the adenosine A(2A) receptor in self-assembled nanodiscs by affinity mass spectrometry

Ma J , Lu Y , Wu D, Peng Y, Loa-Kum-Cheung W ,Peng C, Quinn RJ, Shui WQ, Liu ZJ .  ANALYTICAL METHODS. 2017 Oct 28;9(40): 5851-5858. doi: 10.1039/c7ay01891f.


7.       Requirement for CCNB1 in mouse spermatogenesis.

Tang JX, Li J, Cheng JM, Hu B, Sun TC, Li XY, Batool A, Wang ZP, Wang XX, Deng SL, Zhang Y, Chen SR, Huang XX, Liu YX. Cell Death Dis. 2017 Oct 26;8(10):e3142. doi: 10.1038/cddis.2017.555.


8.       Wisp2 disruption represses Cxcr4 expression and inhibits BMSCs homing to injured liver.

Qin D#, Yan Y#, Hu B#, Zhang W, Li H, Li X, Liu S, Dai D, Hu X, Huang XX, Zhang L. Oncotarget. 2017 Oct 24;8(58):98823-98836. doi: 10.18632/oncotarget.22006. eCollection 2017 Nov 17.


9.       YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.

Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang XX, Guerrero L, Xie P, He E, Shen B, He C. Elife. 2017 Oct 6;6. pii: e31311. doi: 10.7554/eLife.31311.


10.   Electrospinning of PVA/sericin nanofiber and the effect on epithelial-mesenchymal transition of A549 cells.

Yan S, Li X, Dai J, Wang Y, Wang B, Lu Y, Shi J, Huang P, Gong J, Yao Y. Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:436-444. doi: 10.1016/j.msec.2017.05.048. Epub 2017 May 10.


11.   Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.

Zhang S, Fan G, Hao Y, Hammell M, Wilkinson JE, Tonks NK. Genes Dev. 2017 Oct 1;31(19):1939-1957. doi: 10.1101/gad.304261.117. Epub 2017 Oct 24.


12.   Highly efficient and precise base editing in discarded human tripronuclear embryos.

Li G, Liu Y, Zeng Y, Li J, Wang L, Yang G, Chen D, Shang X, Chen J, Huang XX, Liu J. Protein Cell. 2017 Oct;8(10):776-779. doi: 10.1007/s13238-017-0458-7.


13.   Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor.

Wang L, Xue W, Yan L, Li X, Wei J, Chen M, Wu J, Yang B, Yang L, Chen J. Cell Res. 2017 Oct;27(10):1289-1292. doi: 10.1038/cr.2017.111. Epub 2017 Aug 29.


14.   Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders.

Xu L, Carrer A, Zonta F, Qu Z, Ma P, Li S, Ceriani F, Buratto D, Crispino G, Zorzi V, Ziraldo G, Bruno F, Nardin C, Peres C, Mazzarda F, Salvatore AM, Raspa M, Scavizzi F, Chu Y, Xie S, Yang X, Liao J, Liu X, Wang W, Wang S, Yang G, Lerner RA, Mammano F, Front Mol Neurosci. 2017 Sep 22;10:298. doi: 10.3389/fnmol.2017.00298. eCollection 2017.


15.   Sparks of the CRISPR explosion: Applications in medicine and agriculture.

Liu JL. J Genet Genomics. 2017 Sep 20;44(9):413-414. doi: 10.1016/j.jgg.2017.09.006.


16.   APOBEC: From mutator to editor.

Yang B, Li X, Lei L, Chen J. J Genet Genomics. 2017 Sep 20;44(9):423-437. doi: 10.1016/j.jgg.2017.04.009. Epub 2017 Aug 7.


17.   Key Elements for Designing and Performing a CRISPR-Cas9 based Genetic Screen.

Shang W, Wang F, Fan G, Wang H. J Genet Genomics. 2017 Sep 20;44(9):439-449. doi: 10.1016/j.jgg.2017.09.005. Epub 2017 Sep 22.


18.   Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.

Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B. Cell Res. 2017 Sep;27(9):1157-1177. doi: 10.1038/cr.2017.103. Epub 2017 Aug 15.


19.   PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes.

Zhang L, Sement FM, Suematsu T, Yu T, Monti S, Huang L, Aphasizhev R1, Aphasizheva I. EMBO J. 2017 Aug 15;36(16):2435-2454. doi: 10.15252/embj.201796808. Epub 2017 Jul 6.


20.   Making human cardiomyocytes up to date: Derivation, maturation state and perspectives.

Kolanowski TJ, Antos CL, Guan K. Int J Cardiol. 2017 Aug 15;241:379-386. doi: 10.1016/j.ijcard.2017.03.099. Epub 2017 Mar 24.


21.   Whole-cell Patch-clamp Recordings of Isolated Primary Epithelial Cells from the Epididymis.

Zhang BL, Gao DY, Zhang XX, Shi S, Shum W. J Vis Exp. 2017 Aug 3;(126). doi: 10.3791/55700.


22.   Crystal structures of agonist-bound human cannabinoid receptor CB1.

Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5.


23.   DNA-binding mechanism of the Hippo pathway transcription factor TEAD4.

Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z. Oncogene. 2017 Jul 27;36(30):4362-4369. doi: 10.1038/onc.2017.24. Epub 2017 Apr 3.


24.   Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.

An B, Wang X, Cui M, Gui X, Mao X, Liu Y, Li K, Chu C, Pu J, Ren S, Wang Y, Zhong G, Lu TK, Liu C, Zhong C. ACS Nano. 2017 Jul 25;11(7):6985-6995. doi: 10.1021/acsnano.7b02298. Epub 2017 Jun 19.


25.   Identification of a hybrid myocardial zone in the mammalian heart after birth.

Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT1, Anderson RH, Zhou B. Nat Commun. 2017 Jul 20;8(1):87. doi: 10.1038/s41467-017-00118-1.


26.   Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.

Li L, Guo X, Shi X, Li C, Wu W, Yan C, Wang H, Li H, Xu C. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5891-E5899. doi: 10.1073/pnas.1701990114. Epub 2017 Jun 28.


27.   3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis.

Ke Y, Xu Y, Chen X, Feng S, Liu Z, Sun Y, Yao X, Li F, Zhu W, Gao L, Chen H, Du Z, Xie W, Xu X, Huang XX, Liu J. Cell. 2017 Jul 13;170(2):367-381.e20. doi: 10.1016/j.cell.2017.06.029.


28.   Loss of Sun2 promotes the progression of prostate cancer by regulating fatty acid oxidation.

Yajun C#, Chen Y#, Xiaosa L#, Xiao W, Jia C, Zhong W, Bin X. Oncotarget. 2017 Jul 12;8(52):89620-89630. doi: 10.18632/oncotarget.19210. eCollection 2017 Oct 27.


29.   Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint.

Hu X, Shen B, Liao S, Ning Y, Ma L, Chen J, Lin X, Zhang D, Li Z, Zheng C, Feng Y, Huang XX, Han C. Cell Death Dis. 2017 Jun 29;8(6):e2910. doi: 10.1038/cddis.2017.228.


30.   A. Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from alphaD-Conotoxin GeXXA

Yang L, Tae HS, Fan Z, Shao X, Xu S, Zhao S, Adams DJ, Wang C. Mar Drugs. 2017 Jun 5;15(6). pii: E164. doi: 10.3390/md15060164.


31.   Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.

Hu R, Zhang J, Luo M, Hu J. Cereb Cortex. 2017 Jun 1;27(6):3110-3124. doi: 10.1093/cercor/bhw175.


32.   CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms.

Yao X, Wang X, Liu J, Hu X, Shi L, Shen X, Ying W, Sun X, Wang X, Huang P, Yang H. EBioMedicine. 2017 Jun;20:19-26. doi: 10.1016/j.ebiom.2017.05.015. Epub 2017 May 11.


33.   Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17.


34.   Homology-mediated end joining-based targeted integration using CRISPR/Cas9.

Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, Shen X, Wei Y, Huang Z, Ying W, Wang Y, Nie YH, Zhang CC, Li S, Cheng L, Wang Q, Wu Y, Huang P, Sun Q, Shi L, Yang H. Cell Res. 2017 Jun;27(6):801-814. doi: 10.1038/cr.2017.76. Epub 2017 May 19.


35.   NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.

Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y. Nat Commun. 2017 Jun 6;8:15662. doi: 10.1038/ncomms15662.


36.   Structural Basis for Apelin Control of the Human Apelin Receptor.

Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. Structure. 2017 Jun 6;25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017 May 18.


37.   Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F.Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383.


38.   Critical roles of CTP synthase N-terminal in cytoophidium assembly.

Huang Y, Wang JJ, Ghosh S, Liu JL. Exp Cell Res. 2017 May 15;354(2):122-133. doi: 10.1016/j.yexcr.2017.03.042. Epub 2017 Mar 22.


39.   A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.

Ye L, Ding K, Zhao F, Liu X, Wu Y, Liu Y, Xue D, Zhou F, Zhang X, Stevens RC, Xu F, Zhao S, Tao H. Medchemcomm. 2017 Apr 28;8(6):1332-1336. doi: 10.1039/c7md00104e. eCollection 2017 Jun 1.


40.   A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse.

Chen J, Du Y, He X, Huang XX, Shi YS. Sci Rep. 2017 Mar 31;7(1):517. doi: 10.1038/s41598-017-00654-2.


41.   Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae.

Wang X, Li S, Wang H, Shui W, Hu J. Elife. 2017 Mar 13;6. pii: e23816. doi: 10.7554/eLife.23816.


42.   A hypothalamic circuit that controls body temperature.

Zhao ZD, Yang WZ, Gao C, Fu X, Zhang W, Zhou Q, Chen W, Ni X, Lin JK, Yang J, Xu XH, Shen WL. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2042-2047. doi: 10.1073/pnas.1616255114. Epub 2017 Jan 4.


43.   Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry.

Li S, Cao Q, Xiao W, Guo Y, Yang Y, Duan X, Shui W. J Proteome Res. 2017 Feb 3;16(2):738-747. doi: 10.1021/acs.jproteome.6b00767. Epub 2017 Jan 3.


44.   The emerging roles of the DDX41 protein in immunity and diseases.

Jiang Y, Zhu Y, Liu ZJ, Ouyang S. Protein Cell. 2017 Feb;8(2):83-89. doi: 10.1007/s13238-016-0303-4. Epub 2016 Aug 9.


45.   Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space.

Zhou Q, Sun X, Xia X, Fan Z, Luo Z, Zhao S, Shakhnovich E, Liang H. J Phys Chem Lett. 2017 Jan 19;8(2):407-414. doi: 10.1021/acs.jpclett.6b02769. Epub 2017 Jan 5.


46.   Structural variation in amyloid-beta fibrils from Alzheimer's disease clinical subtypes.

Qiang W, Yau WM, Lu JX, Collinge J, Tycko R. Nature. 2017 Jan 12;541(7636):217-221. doi: 10.1038/nature20814. Epub 2017 Jan 4.


47.   GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary.

Jiang C, Diao F, Sang YJ, Xu N, Zhu RL, Wang XX, Chen Z, Tao WW, Yao B, Sun HX, Huang XX, Xue B, Li CJ. PLoS Genet. 2017 Jan 10;13(1):e1006535. doi: 10.1371/journal.pgen.1006535. eCollection 2017 Jan.


48.   Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities.

Yang LY, Liu XF, Yang Y, Yang LL, Liu KW, Tang YB, Zhang M, Tan MJ, Cheng SM, Xu YC, Yang HY, Liu ZJ, Song GJ, Huang W. Acta Pharmacol Sin. 2017 Jan;38(1):56-68. doi: 10.1038/aps.2016.89. Epub 2016 Sep 19.


49.   Single-Molecule Optical-Trapping Techniques to Study Molecular Mechanisms of a Replisome.

Sun B, Wang MD. Methods Enzymol. 2017;582:55-84. doi: 10.1016/bs.mie.2016.08.001. Epub 2016 Oct 27.


50.   A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.

Koledova Z, Lu P. Methods Mol Biol. 2017;1501:217-231.


51.   Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis.

Li Z, Li Y, Chen W, Cao Q, Guo Y, Wan N, Jiang X, Tang YJ, Wang Q, Shui W.Anal Chem. 2017 Jan 3;89(1):877-885. doi: 10.1021/acs.analchem.6b03947. Epub 2016 Dec 14.


52.   Solid-State Structure of Abeta (Aβ) in Alzheimer's Disease.

Lu JX, Dong XQ, Zhang JJ. Protein Pept Lett.2017;24(4):322-330. doi: 10.2174/0929866524666170208155108.


53.   Building Cre Knockin Rat Lines Using CRISPR/Cas9.

Ma Y, Zhang L, Huang XX.  Methods in Molecular Biology 2017;1642, 37-52.


54.   TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.

Luo J, Shen WL, Montell C. Nat Neurosci. 2017 Jan;20(1):34-41. doi: 10.1038/nn.4416. Epub 2016 Oct 17.


55.   Chapter 15 - Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies A2 - Tollefsbol, Trygve O.

Mao S, Li Y, Liu B, Chi T.  In Handbook of Epigenetics (Second edition) (Academic Press), pp. 231-243.


56.   Genomic Tagging of AGO1 using CRISPR/Cas9-mediated Homologous Recombination.

Ghosh S, Liu JL.  Methods Mole Biol.1680:217-235.




Achievement in the year of 2016


1.       Efficient generation of B2m-null pigs via injection of zygote with TALENs.

Wang Y, Du Y, Zhou X, Wang L, Li J, Wang F, Huang Z, Huang XX, Wei H. Sci Rep. 2016 Dec 16;6:38854. doi: 10.1038/srep38854.


2.       CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer.

Su S, Zou Z, Chen F, Ding N, Du J, Shao J, Li L, Fu Y, Hu B, Yang Y, Sha H, Meng F, Wei J, Huang XX, Liu B. Oncoimmunology. 2016 Nov 22;6(1):e1249558. doi: 10.1080/2162402X.2016.1249558. eCollection 2017.


3.       Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration.

Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B. Nat Commun. 2016 Nov 18;7:13369. doi: 10.1038/ncomms13369.


4.       Structural basis for DNA recognition by STAT6.

Li J , Rodriguez JP , Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J6, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13015-13020. Epub 2016 Nov 1.


5.       Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia.

Yao L, Lu P, Ling EA. PLoS One. 2016 Nov 3;11(11):e0166010. doi: 10.1371/journal.pone.0166010. eCollection 2016.


6.       Crystal Structure of the Human Cannabinoid Receptor CB1.

Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.  Cell. 2016 Oct 20;167(3):750-762.e14. doi: 10.1016/j.cell.2016.10.004.


7.       Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers.

Wang X, Cai B, Zhou J, Zhu H, Niu Y, Ma B, Yu H, Lei A, Yan H, Shen Q, Shi L, Zhao X, Hua J, Huang X, Qu L, Chen Y. PLoS One. 2016 Oct 18;11(10):e0164640. doi: 10.1371/journal.pone.0164640. eCollection 2016.


8.       Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.

Hill ZB, Pollock SB, Zhuang M, Wells JA. J Am Chem Soc. 2016 Oct 12;138(40):13123-13126. Epub 2016 Sep 28.


9.       Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System.

Hu R, Jin S, He X, Xu F, Hu J. Front Neuroanat. 2016 Oct 10;10:98. eCollection 2016.


10.   Porcine Zygote Injection with Cas9/sgRNA Results in DMD-Modified Pig with Muscle Dystrophy.

Yu HH, Zhao H, Qing YB, Pan WR, Jia BY, Zhao HY, Huang XX, Wei HJ.  Int J Mol Sci. 2016 Oct 9;17(10). pii: E1668.


11.   The Cytoophidium and Its Kind: Filamentation and Compartmentation of Metabolic Enzymes.

Liu JL. Annu Rev Cell Dev Biol. 2016 Oct 6;32:349-372. Epub 2016 Jun 27.


12.   Antigen Receptor Nanoclusters: Small Units with Big Functions.

Liu W, Wang H, Xu C. Trends Immunol. 2016 Oct;37(10):680-689. doi: 10.1016/ Epub 2016 Aug 20.


13.   SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P.Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5731-40. doi: 10.1073/pnas.1611532113. Epub 2016 Sep 12.


14.   Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.

Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V.  Sci Adv. 2016 Sep 23;2(9):e1600292. eCollection 2016 Sep.


15.   aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism.

Chu Y, Zhu Y, Chen Y, Li W, Zhang Z, Liu D, Wang T, Ma J, Deng H, Liu ZJ, Ouyang S, Huang L.

Mol Cell Proteomics. 2016 Sep;15(9):2908-23. doi: 10.1074/mcp.M115.057778. Epub 2016 Jun 21.


16.    Mitrocomin from the jellyfish Mitrocoma cellularia with deleted C-terminal tyrosine reveals a higher bioluminescence activity compared to wild type photoprotein.

Burakova LP, Natashin PV, Markova SV, Eremeeva EV, Malikova NP, Cheng C, Liu ZJ, Vysotski ES.

J Photochem Photobiol B. 2016 Sep;162:286-297. doi: 10.1016/j.jphotobiol.2016.06.054. Epub 2016 Jul 2.


17.   TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.

Ke Q, Li W, Lai X, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q, Yang S, Xiang AP. Cell Res. 2016 Sep;26(9):1048-61. doi: 10.1038/cr.2016.93. Epub 2016 Aug 9.


18.   STRIPAK complexes in cell signaling and cancer.

Shi Z, Jiao S, Zhou Z. Oncogene. 2016 Sep 1;35(35):4549-57. doi: 10.1038/onc.2016.9. Epub 2016 Feb 15.


19.   Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.

Zhao Y, Zhang T, Huo H, Ye Y, Liu Y.J Biol Chem. 2016 Aug 26;291(35):18252-62. doi: 10.1074/jbc.M116.737783. Epub 2016 Jul 7.


20.   Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep.

Wang X, Niu Y, Zhou J, Yu H, Kou Q, Lei A, Zhao X, Yan H, Cai B, Shen Q, Zhou S, Zhu H, Zhou G, Niu W, Hua J, Jiang Y, Huang XX, Ma B, Chen Y. Sci Rep. 2016 Aug 26;6:32271. doi: 10.1038/srep32271.


21.   Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis.

Gao da Y, Zhang BL, Leung MC, Au SC, Wong PY, Shum WW. J Gen Physiol. 2016 Aug;148(2):161-82. doi: 10.1085/jgp.201611626.


22.   Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches.

Fu X, Wang Z, Li L, Dong S, Li Z, Jiang Z, Wang Y, Shui W.Sci Rep. 2016 Jul 12;6:29680. doi: 10.1038/srep29680.


23.   Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein.

Ma Y, Chen W, Zhang X, Yu L, Dong W, Pan S, Gao S, Huang XX, Zhang L. RNA Biol. 2016 Jul 2;13(7):605-12. doi: 10.1080/15476286.2016.1185591. Epub 2016 May 10.


24.   Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.

He Q, Wang F, Liu S, Zhu D, Cong H, Gao F, Li B, Wang H, Lin Z, Liao J, Gu L. J Biol Chem. 2016 Jul 1;291(27):14386-7. doi: 10.1074/jbc.A115.699801.


25.   Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments.

 Lu JX, Bayro MJ, Tycko R. J Biol Chem. 2016 Jun 17;291(25):13098-112. doi: 10.1074/jbc.M116.720557. Epub 2016 Apr 19.


26.   Somatic human ZBTB7A zinc finger mutations promote cancer progression.

Liu XS, Liu Z, Gerarduzzi C, Choi DE, Ganapathy S, Pandolfi PP, Yuan ZM. Oncogene. 2016 Jun 9;35(23):3071-8. doi: 10.1038/onc.2015.371. Epub 2015 Oct 12.


27.   Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology.

Barthmes M, Liao J, Jiang Y, Brüggemann A, Wahl-Schott C. J Gen Physiol. 2016 Jun;147(6):485-96. doi: 10.1085/jgp.201611587.


28.   Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.

Liao J#, Marinelli F#, Lee C, Huang Y, Faraldo-Gómez JD, Jiang Y. Nat Struct Mol Biol. 2016 Jun;23(6):590-599. doi: 10.1038/nsmb.3230. Epub 2016 May 16.


29.   A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.

Zou Y, Chintamanani S, He P, Fukushige H, Yu L, Shao M, Zhu L, Hildebrand DF, Tang X, Zhou JM. J Integr Plant Biol. 2016 Jun;58(6):600-9. doi: 10.1111/jipb.12427. Epub 2015 Nov 13.


30.   An activation-induced IL-15 isoform is a natural antagonist for IL-15 function.

Zhao L, Hu B, Zhang Y, Song Y, Lin D, Liu Y, Mei Y, Sandikin D, Sun W, Zhuang M, Liu H. Sci Rep. 2016 May 11;6:25822. doi: 10.1038/srep25822.


31.   Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans.

Ying L, Zhu H. Worm. 2016 May 4;5(3):e1184814. eCollection 2016.


32.   MLKL forms cation channels.

Xia B, Fang S, Chen X, Hu H, Chen P, Wang H, Gao Z. Cell Res. 2016 May;26(5):517-28. doi: 10.1038/cr.2016.26. Epub 2016 Apr 1.


33.   In vitro expression and analysis of the 826 human G protein-coupled receptors.

Lv X, Liu J, Shi Q, Tan Q, Wu D, Skinner JJ, Walker AL, Zhao L, Gu X, Chen N, Xue L, Si P, Zhang L, Wang Z, Katritch V, Liu ZJ, Stevens RC. Protein Cell. 2016 May;7(5):325-37. doi: 10.1007/s13238-016-0263-8. Epub 2016 Apr 16.


34.    Generation of an Oocyte-Specific Cas9 Transgenic Mouse for Genome Editing.

Zhang L, Zhou J, Han J, Hu B, Hou N, Shi Y, Huang XX, Lou X. PLoS One. 2016 Apr 27;11(4):e0154364. doi: 10.1371/journal.pone.0154364. eCollection 2016.


35.   Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.

Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2001-10. doi: 10.1073/pnas.1524900113. Epub 2016 Mar 22.


36.   Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding.

Jiang Y, Jiang H, Zhou S, Meng B, Liu ZJ, Ouyang S. Biochem Biophys Res Commun. 2016 Mar 18;471(4):621-7. doi: 10.1016/j.bbrc.2016.01.150. Epub 2016 Jan 26.


37.   Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.

Dong X, Chiu H, Park YJ, Zou W, Zou Y, Özkan E, Chang C, Shen K. Elife. 2016 Mar 14;5. pii: e11008. doi: 10.7554/eLife.11008.


38.   H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.

Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik DG, Jin Y, Zhang Y, Huang XX, Li J, Wong J. Stem Cells. 2016 Mar;34(3):565-80. doi: 10.1002/stem.2250. Epub 2016 Jan 19.


39.   New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.

Ni X, Ru H, Ma F, Zhao L, Shaw N, Feng Y, Ding W, Gong W, Wang Q, Ouyang S, Cheng G, Liu ZJ. J Mol Cell Biol. 2016 Feb;8(1):51-61. doi: 10.1093/jmcb/mjv053. Epub 2015 Aug 5.


40.   Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes.

Shi XL, Gao Y, Yan Y, Ma H, Sun L, Huang P, Ni X, Zhang L, Zhao X, Ren H, Hu D, Zhou Y, Tian F, Ji Y, Cheng X, Pan G, Ding YT, Hui L2. Cell Res. 2016 Feb;26(2):206-16. doi: 10.1038/cr.2016.6. Epub 2016 Jan 15.


41.   CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

Su S, Hu B, Shao J, Shen B, Du J, Du Y, Zhou J, Yu L, Zhang L, Chen F, Sha H, Cheng L, Meng F, Zou Z, Huang XX, Liu B. Sci Rep. 2016 Jan 28;6:20070. doi: 10.1038/srep20070.


42.   Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.

Wang C, Gu Y, Zhang K, Xie K, Zhu M, Dai N, Jiang Y, Guo X, Liu M, Dai J, Wu L, Jin G, Ma H, Jiang T, Yin R, Xia Y, Liu L, Wang S, Shen B, Huo R, Wang Q, Xu L, Yang L, Huang XX, Shen H, Sha J, Hu Z. Nat Commun. 2016 Jan 27;7:10499. doi: 10.1038/ncomms10499.


43.    All Ca2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin.

Burakova LP,Natashin PV,Malikova NP,Niu FF,Pu MC,Vysotski ES ,Liu ZJ. J Photochem Photobiol B. 2016 Jan;154:57-66. doi: 10.1016/j.jphotobiol.2015.11.012


44.    Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes.

Zhou X, Wang L, Du Y, Xie F, Li L, Liu Y, Liu C, Wang S, Zhang S, Huang XX, Wang Y, Wei H. Hum Mutat. 2016 Jan;37(1):110-8. doi: 10.1002/humu.22913. Epub 2015 Oct 23.


45.   A CRISPR-Based Toolbox for Studying T Cell Signal Transduction.

Chi S, Weiss A, Wang H.Biomed Res Int. 2016;2016:5052369. doi: 10.1155/2016/5052369. Epub 2016 Feb 1.


46.   Single-molecule perspectives on helicase mechanisms and functions.

Sun B, Wang MD. Crit Rev Biochem Mol Biol. 2016;51(1):15-25. doi: 10.3109/10409238.2015.1102195. Epub 2015 Nov 5.


47.   Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer.

Huang P, Li B, Zheng Y W. (2016). Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer. In Stem Cells in Toxicology and Medicine (John Wiley & Sons, Ltd), pp. 363-374.



Achievement in the year of 2015


1.          CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH.

Kang Y, Zheng B, Shen B, Chen Y, Wang L, Wang J, Niu Y, Cui Y, Zhou J, Wang H, Guo X, Hu B, Zhou Q, Sha J, Ji W, Huang XHum Mol Genet. 2015 Dec 20;24(25):7255-64.


2.          T7 replisome directly overcomes DNA damage.

Sun B, Pandey M, Inman JT, Yang Y, Kashlev M, Patel SS, Wang MD.Nat Commun. 2015 Dec 17;6:10260.


3.           Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling.

Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ.Stem Cell Reports. 2015 Nov 10;5(5):816-828.


4.           LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP.Nat Commun. 2015 Oct 8;6:8325.


5.          Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system.

Wang X, Yu H, Lei A, Zhou J, Zeng W, Zhu H, Dong Z, Niu Y, Shi B, Cai B, Liu J, Huang S, Yan H, Zhao X, Zhou G, He X, Chen X, Yang Y, Jiang Y, Shi L, Tian X, Wang Y, Ma B, Huang X, Qu L, Chen Y.Sci Rep. 2015 Sep 10;5:13878.


6.          Breaking bad: The mutagenic effect of DNA repair.

Chen J, Furano AV.DNA Repair (Amst). 2015 Aug;32:43-51.


7.          CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.

Zi Z, Zhang Z, Li Q, An W, Zeng L, Gao D, Yang Y, Zhu X, Zeng R, Shum WW, Wu J.CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.PLoS Genet. 2015 Aug 25;11(8):e1005485.


8.          Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA.

Du Y, Meng Q, Zhang J, Sun M, Shen B, Jiang H, Kang N, Gao J, Huang X, Liu J.Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA.Cell Res. 2015 Jul;25(7):877-80.


9.          The Role of Stroma in Tumor Development.

Werb Z, Lu P.The Role of Stroma in Tumor Development.Cancer J. 2015 Jul-Aug;21(4):250-3.


10.       TP53 loss creates therapeutic vulnerability in colorectal cancer.

Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X.TP53 loss creates therapeutic vulnerability in colorectal cancer.Nature. 2015 Apr 30;520(7549):697-701.


11.       The importance of ligands for G protein-coupled receptor stability.

Zhang X, Stevens RC, Xu F.Trends Biochem Sci. 2015 Feb;40(2):79-87. 



Achievement in the year of 2014


1.       Crystal structure of the N-terminal methyltransferase-like domain of anamorsin.

Song G, Cheng C, Li Y, Shaw N, Xiao ZC, Liu ZJ. Proteins. 2014 Jun;82(6):1066-71.


2.       NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP. Immunity. 2014 Mar 20;40(3):329-41.


3.       Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a re versible intermediate maturation stage.

Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu ZJ. Cell Res. 2014 Mar;24(3):344-58.


4.       Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins.

Natashin PV, Markova SV, Lee J, Vysotski ES, Liu ZJ.  FEBS J. 2014 Mar;281(5):1432-45.


5.       Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction.

Natashin PV, Ding W, Eremeeva EV, Markova SV, Lee J, Vysotski ES, Liu ZJ.  Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):720-32.